Comparative study of topical 5-aminolevulinic acid photodynamic therapy and surgery for the treatment of vulvar squamous intraepithelial lesion

Zhou, Mengjiao; Su, Yuehui; Tong, Yutong; Zhang, Chunyan; Yuan, Shuyu; Zhang, Mengzhuo; Dai, Kaili; Wang, Yimeng; Cao, Lili; Zhang, Mengzhen; Zhang, Ting

doi:10.1016/j.pdpdt.2023.103868

Cited by 1 publication

(1 citation statement)

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“…In recent years, PDT mediated by ALA has been increasingly recognized for its high cure rate of HPV-infected cervical, vaginal, and vulvar SILs [10][11][12]. Systematic reviews and meta-analyses suggest that PDT may be a practical approach in CIN (LSIL) treatment compared with placebo treatment [13].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of 5-Aminolevulinic Acid-Mediated Photodynamic Therapy and the Loop Electrosurgical Excision Procedure for the Treatment of Cervical High-Grade Squamous Intraepithelial Lesions

Wang,

Xu,

et al. 2024

Pharmaceutics

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The loop electrosurgical excision procedure (LEEP) is a common treatment for cervical intraepithelial neoplasia (CIN). Photodynamic therapy (PDT) mediated by 5-aminolevulinic acid (ALA) is a non-invasive modality that has been used for treating precancerous diseases and HPV infections. This comparative study evaluated the efficacy and safety of ALA PDT and the LEEP in the treatment of cervical high-grade squamous intraepithelial lesions (HSILs). Patient records were reviewed and HSIL patients with HPV infections (24–51 years old) who underwent PDT or LEEP treatment were selected. Efficacy was analyzed blindly based on HPV-DNA, cytology, and colposcopy-directed biopsy obtained at 6 months after treatment. Treatment-related discomfort and side effects were also analyzed. Cure rates of 88.1% and 70.0% were achieved for the PDT group and LEEP group (p < 0.05), respectively. HPV-negative conversion rates of 81.0% and 62.0% were achieved for the PDT group and LEEP group (p < 0.05), respectively. The overall lesion remission rate of the PDT group was 19% higher than that of the LEEP group. The incidence of side effects was much lower in the PDT group. These results show that ALA PDT is a feasible non-invasive treatment for cervical HSIL.

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