Comparative study of two silica mesoporous materials (SBA-16 and SBA-15) modified with a hydroxyapatite layer for clindamycin controlled delivery

González, Gema; Sagarzazu, A.; Cordova, Amaia; Gomes, Maria E.; Salas, Janet; Contreras, Leglys; Noris-Suárez, Karem; Lascano, Luis

doi:10.1016/j.micromeso.2017.07.021

Cited by 45 publications

(33 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Parent SBA-15 and SBA-16 materials exhibited type IV isotherms characteristic of mesoporous solids with microporous content. SBA-15 isotherm presented H1 hysteresis loop typical of mesoporous materials with one dimensional cylindrical channels opened at both sides (Gonzalez et al, 2018) (Fig. 4a).…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of mesoporous SBA-15 and SBA-16 as carriers to improve albendazole dissolution rate

Adrover

Pedernera

Bonne

et al. 2020

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

Albendazole (ABZ, anti-parasitic active pharmaceutical ingredient) is a crystalline low water-soluble drug, thus the dissolution rate in gastrointestinal fluids is limited. Consequently, the improvement of the water solubility and dissolution rate of ABZ implies a great challenge for a more efficient treatment of hydatidosis. In this context, SBA-15 and SBA-16 ordered mesoporous silica materials were synthetized and loaded with ABZ. X-ray diffraction, FT-IR spectroscopy, nitrogen physisorption manometry, particle size distribution and scanning electronic microscopy were used to characterize unloaded and loaded materials (ABZ/SBA-15 and ABZ/SBA-16). The loaded ABZ amount in the carriers was estimated by elemental analysis. For the loaded materials, the drug solubility and release profile were evaluated. In addition, mathematical models were compared to explain the dissolution kinetics of ABZ from mesoporous solids. ABZ was successfully loaded into the mesopores. The amorphous state of the adsorbed ABZ was confirmed by differential scanning calorimetry that resulted in a notable increment in the dissolution rate compared to crystalline ABZ. Drug release behaviors were well simulated by the Weibull model for ABZ/SBA-15 and by the Gompertz function for pure ABZ and ABZ/SBA-16. The SBA-15 carrier exhibited the highest drug loading and dissolution rate becoming a promising material to improve ABZ bioavailability.

show abstract

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of mesoporous SBA-15 and SBA-16 as carriers to improve albendazole dissolution rate

Adrover

Pedernera

Bonne

et al. 2020

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

show abstract

“…132 The SBA-16 support has a cubic structure consisting of non-interpenetrating 3D channels with cavities with a width 5-15 nm. 133 Even though functionalising SBA-16 with tetrabutylammonium iodide and imidazolium based groups decreased the surface area, volume and pore size of the support, the carbon dioxide adsorption capacities of these supports were greater than that of SBA-16 itself. This was hypothesised to be due to the introduction of iodide and amine groups, which were described as "CO 2 -philic" groups.…”

Section: Immobilised Systemsmentioning

confidence: 99%

Recent developments in organocatalysed transformations of epoxides and carbon dioxide into cyclic carbonates

2021

View full text Add to dashboard Cite

show abstract

“…The same results have been observed by Nagarajan et al They added boron nitride and graphene oxide to electrospun gelatin nanofibers separately, which then led to improved mechanical strength and scaffold–tissue interactions. The ability of bioactive ceramics, such as hydroxyapatite (HAP), calcium phosphate, and bioactive glasses (BG) to react with physiological fluids also resulted in the formation of mineralized layers and superior regeneration of bone defects . BG has proven to be a promising candidate to induce osteoinductivity for bone tissue engineering applications .…”

Section: Introductionmentioning

confidence: 99%

The Tunable Porous Structure of Gelatin–Bioglass Nanocomposite Scaffolds for Bone Tissue Engineering Applications: Physicochemical, Mechanical, and In Vitro Properties

Arabi

Zamanian

Rashvand

et al. 2018

Macro Materials & Eng

View full text Add to dashboard Cite

Unidirectional freeze‐casting method is used to fabricate gelatin–bioglass nanoparticles (BGNPs) scaffolds. Transmission electron microscopy (TEM) images show that sol–gel prepared BGNPs are distributed throughout the scaffold with diameters of less than 10 nm. Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetric are used to evaluate the physicochemical properties of BGNPs. Scanning electron microscopy (SEM) micrographs present an oriented porous structure and a homogeneous distribution of BGNPs in the gelatin matrix. The lamellar‐type structure indicates an improvement of mechanical strength and absorption capacity of the scaffolds. Increasing the concentration of BGNPs from 0 to 50 wt% have no noticeable effect on pore orientation, but decreases porosity and pore size distribution. Increase in BGNPs content improves the compressive strength. The absorption and biodegradation rate reduces with augmentation in BGNPs concentration. Bioactivity is evaluated through apatite formation after immersion of the nanocomposites in simulated body fluid and is verified by SEM–energy‐dispersive X‐ray spectroscopy (EDS), an element map analysis, X‐ray powder diffractometer, and FTIR spectrum. SEM images and methyl thiazolyl tetrazolium assay confirm the biocompatibility of scaffolds and the supportive behavior of nanocomposites in cellular spreading. The results show that gelatin–(30 wt%)bioglass nanocomposites have incipient physicochemical and biological properties.

show abstract

Comparative study of two silica mesoporous materials (SBA-16 and SBA-15) modified with a hydroxyapatite layer for clindamycin controlled delivery

Cited by 45 publications

References 34 publications

Synthesis and characterization of mesoporous SBA-15 and SBA-16 as carriers to improve albendazole dissolution rate

Synthesis and characterization of mesoporous SBA-15 and SBA-16 as carriers to improve albendazole dissolution rate

Recent developments in organocatalysed transformations of epoxides and carbon dioxide into cyclic carbonates

The Tunable Porous Structure of Gelatin–Bioglass Nanocomposite Scaffolds for Bone Tissue Engineering Applications: Physicochemical, Mechanical, and In Vitro Properties

Contact Info

Product

Resources

About