Comparative Study of Vitamin E Levels of Nigerian Men and Age-matched Fertile and Infertile Women

Makinde, K. A.; Adedeji, O. O.

doi:10.3109/13590849409034539

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…In addition, vitamin E levels in sera and cervical secretions of infertile women with unexplained infertility showed significant decrease (P<0.05; P<0.001, respectively, when compared with fertile controls (Table 4). This result matched with that obtained by (34) who stated that plasma vitamin E level is greater in fertile than in infertile women.Also, (25) suggested that increased OS was associated with decrease of antioxidants and higher incidence of infertility. Vitamin E (straightly equalizes superoxide anion, hydrogen peroxide and hydroxyl radical) so rises levels of these types of free radical may lead to depletion of vitamin E. Also, vitamin E progresses number of embryos increasing to the expanded blastocysts and increases ability of embryos exposed to heat shock.…”

Section: January 2020 Vol 23 (I) ©Annals Of Tropical Medicine and Public Health S387supporting

confidence: 90%

The Role of free radicals in female unexplained subfertility

Edan¹,

Shakir²,

Al-Mukhtar³

2020

ATMPH

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Background:Unexplained sub-fertility is commonly identified if couples fail to conceive after 1 yr of everyday unprotected sexual intercourse even though investigations for ovulation, tubal patency and semen evaluation are ordinary. For as many as (30-40%) of couples experiencing sub-fertility, their subfertility stays unexplained. The objective of current study was to estimate and calculate the reactive oxygen species and to determine the relationship between free radicals, antioxidant enzyme activities and unexplained subfertility. Methods: The study was an observational prospective study involved two groups of women who attended Babylon maternity Hospital and private clinic. The study groups included 30 apparently healthy fertile women as a control group and 60 women with subfertility. Blood withdrawn from both groups for biochemical evaluation of MDA, GSH, vitamin E and vitamin C. Cervical secretions were also collected from both groups for same enzymatic and non-enzymatic free radicals evaluations. Results: The results showed that MAD levels were increased significantly (P<0.01) in serum and cervical mucus secretions in patient group compared with control group. In addition, GSH levels decreased significantly (P<0.05). Also, vitamin C levels decreased significantly (P>0.05) in serum and cervical mucus secretion in patient group comparing with control group. Finally, vitamin E levels decreased significantly (P<0.05) in serum and cervical mucus secretion in patient groups comparing with control groups. Conclusion: Oxidative stress plays an important role in human fertility.

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Section: January 2020 Vol 23 (I) ©Annals Of Tropical Medicine and Public Health S387supporting

confidence: 90%

The Role of free radicals in female unexplained subfertility

Edan¹,

Shakir²,

Al-Mukhtar³

2020

ATMPH

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“…10 Plasma vitamin E levels were found to be higher in fertile women than in infertile women. 11 Vitamin E supplementation in older mice partially prevented reduction in ovulation 12 Vitamin E has a significant role in reproduction and sufficient levels give a better effectiveness in the treatment of unexplained infertile women.…”

Section: Role Of Vitamin E In Fertilitymentioning

confidence: 99%

Evaluation of vitamin E levels, antioxidant enzymes and malondialdehyde in women with unexplained infertility

Vanitha S,

Job,

Aleyamma T K

2023

IJCBR

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Unexplained infertility is a perplexing disorder. 30% of infertile couples are diagnosed with unexplained infertility with all standard fertility investigations normal. Oxidative stress has been shown to have a negative impact on reproductive function in women with endometriosis and (PCOS) polycystic ovarian syndrome. In another study antioxidant supplementation improved OS induced infertility. Many studies have demonstrated an increase in Malondialdehyde in serum of women with infertility and vitamin E as a protective antioxidant in the body with positive effect on the fertility. There is growing evidence linking OS and unexplained infertility.Based on this knowledge the specific group of unexplained infertile women were chosen to assess their levels of serum antioxidant enzymes, Vitamin E and lipid peroxidation marker. To compare the Levels of Malondialdehyde, Antioxidant enzymes and Vitamin E in the serum of women with unexplained infertility and control group.: Case control study.70 normal ovulatory women who conceived within 12 months of contraceptive free intercourse, and with no history of miscarriage were recruited in the control group. 70 women with unexplained infertility were recruited as study group. All participants included in the study were between 28 and 38 years of age. Serum levels of MDA, Antioxidant enzymes (GST, SOD, Catalase) and Vitamin E concentrations were compared between two groups. Vitamin E concentrations were determined by using High performance liquid chromatography. Antioxidant enzymes and MDA were measured by standard spectrophotometric assay.: Data was analysed using SPSS Software. Continuous parameters were analysed using Mann Whitney U test. There is a significant decrease in the vitamin E levels 3.80 ug/ml) in the unexplained infertile group as compared to controls 6.0 ug/ml). All women in the study group showed significantly (P<0.05) higher levels of MDA and lower levels of antioxidant enzymes such as GST, SOD and Catalase as compared to the fertile women. This decrease was found to be significant with p value of <0.05. The study group have a higher oxidative stress status and low level of antioxidants compared to control group. Serial measurement of oxidative stress biomarkers and their defense system may help to understand the aetiology of unexplained infertility and to enhance their chances of conception.

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Comparative Study of Vitamin E Levels of Nigerian Men and Age-matched Fertile and Infertile Women

Cited by 2 publications

References 4 publications

The Role of free radicals in female unexplained subfertility

The Role of free radicals in female unexplained subfertility

Evaluation of vitamin E levels, antioxidant enzymes and malondialdehyde in women with unexplained infertility

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