Comparative study of zinc oxide nanoparticles synthesized through biogenic and chemical route with reference to antibacterial, antibiofilm and anticancer activities

Nallasamy, Prakashkumar; Brindhadevi, Kathirvel; Garalleh, Hakim Al; Garaleh, Mazen; Suganthy, Natarajan

doi:10.1016/j.envres.2022.115136

Cited by 13 publications

(5 citation statements)

References 31 publications

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“…95 ZnO NPs have been biosynthesised using plant extracts, microorganisms like algae, bacteria, and fungi, and enzymes like alphaamylase. Several studies have shown that green synthesized ZnO NPs are effective against PA. 96 In comparison to the chemical synthesis of ZnO NPs, Prakashkumar et al found that biogenic synthesis ensured biosafety and enhanced biological activity, 14 which is consistent with the view of Darvishi. 97…”

Section: Zinc Oxide Nanoparticles (Zno Nps)mentioning

confidence: 55%

“…Several studies have shown that green synthesized ZnO NPs are effective against PA 96 . In comparison to the chemical synthesis of ZnO NPs, Prakashkumar et al found that biogenic synthesis ensured biosafety and enhanced biological activity, 14 which is consistent with the view of Darvishi 97 …”

Section: Therapeutic Strategy Based On Mnps and Monpsmentioning

confidence: 70%

“…(B) Antimicrobial mechanisms of Cu/CuO NPs 59 . (C) Photocatalytic mechanisms of CuO NPs and Cu 2 O NPs 14,60 …”

Section: Therapeutic Strategy Based On Mnps and Monpsmentioning

confidence: 99%

“…21 T A B L E 1 The empirical antibiotics used in the treatment of Pseudomonas aeruginosa (PA) infection and their mechanisms of action. 5 Antibiotics used to treat PA 14 Examples Mechanism…”

Section: Therapeutic Strategy Based On Mnps and Monpsmentioning

confidence: 99%

“…59 (C) Photocatalytic mechanisms of CuO NPs and Cu 2 O NPs. 14,60 due to co-existing chemicals like gold ions, surface-coating agents, and synthesis process chemicals. The origin or mechanism behind this effect remains unclear.…”

Section: Gold Nanoparticles (Au Nps)mentioning

confidence: 99%

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Therapeutic strategies for drug‐resistant Pseudomonas aeruginosa: Metal and metal oxide nanoparticles

Zhan,

Hu,

et al. 2024

J Biomedical Materials Res

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Pseudomonas aeruginosa (PA) is a widely prevalent opportunistic pathogen. Multiple resistant strains of PA have emerged from excessive or inappropriate use of antibiotics, making their eradication increasingly difficult. Therefore, the search for highly efficient and secure novel antimicrobial agents is crucial. According to reports, there is an increasing exploration of nanometals for antibacterial purposes. The antibacterial mechanisms involving the nanomaterials themselves, the release of ions, and the induced oxidative stress causing leakage and damage to biomolecules are widely accepted. Additionally, the study of the cytotoxicity of metal nanoparticles is crucial for their antibacterial applications. This article summarizes the types of metal nanomaterials and metal oxide nanomaterials that can be used against PA, their respective unique antibacterial mechanisms, cytotoxicity, and efforts made to improve antibacterial performance and reduce toxicity, including combination therapy with other materials and antibiotics, as well as green synthesis approaches.

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Section: Zinc Oxide Nanoparticles (Zno Nps)mentioning

confidence: 55%

Section: Therapeutic Strategy Based On Mnps and Monpsmentioning

confidence: 70%

“…(B) Antimicrobial mechanisms of Cu/CuO NPs 59 . (C) Photocatalytic mechanisms of CuO NPs and Cu 2 O NPs 14,60 …”

Section: Therapeutic Strategy Based On Mnps and Monpsmentioning

confidence: 99%

Section: Therapeutic Strategy Based On Mnps and Monpsmentioning

confidence: 99%

Section: Gold Nanoparticles (Au Nps)mentioning

confidence: 99%

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Therapeutic strategies for drug‐resistant Pseudomonas aeruginosa: Metal and metal oxide nanoparticles

Zhan,

Hu,

et al. 2024

J Biomedical Materials Res

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Inorganic nanoparticles: An effective antibiofilm strategy

Tanwar,

Parauha,

There

et al. 2024

Luminescence

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Biofilm is a common problem associated with human health. Pathogenicity and increase in resistance of bacteria require urgent development of effective ways for the treatment of bacterial diseases. Different strategies have been developed for the treatment of bacterial infections among which nanoparticles have shown greater prospects in battling with infections. Biofilms are resistant microbial colonies that possess resistance and, hence, cannot be killed by conventional drugs. Nanoparticles offer new avenues for treating biofilm‐related infections involving multi‐drug resistant organisms. They possess great antibiofilm properties, disrupting cell architecture and preventing colony formation. Green‐synthesised nanoparticles are more effective and less toxic to human cells than commercially available or chemically synthesised antibiofilm nanoparticles. This review summarises the antibiofilm efficiency of plant‐mediated nanoparticles and knowledge about biofilm inhibition.

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Antibacterial and Antibiofilm Activity of Zinc Oxide Quantum Dots against Methicillin‐resistant Staphylococcus aureus

Abbas,

Abdullah,

Hallaji

et al. 2024

Part & Part Syst Charact

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Antimicrobial resistance occurs mostly through the ineffective and unauthorized use of antibiotics in both the environment and health care. Biofilms are a new target in the search for new antibacterial agents. Here, the sol‐gel method is used to produce zinc oxide quantum dots (ZnO‐QDs). The ZnO‐QDs show yellow emission at 526 nm under 360 nm excitation. After that, the ability of ZnO‐QDs as an antibacterial and antibiofilm agent against methicillin‐resistant Staphylococcus aureus (MRSA) is examined. The 100 samples are collected from patients with hospital‐acquired infections between December 2020 and October 2021 from Imamen Kadhmiyan Teaching Hospital in Baghdad (Iraq). Out of these 100 samples, 63 are S. aureus and 20 out of 63 are MRSA. The minimum inhibitory concentration assay demonstrates the antibacterial activity of ZnO‐QDs on MRSA strains. Also, results show that 80, 5, and 15% of isolated MRSA strains produce strong, moderate, and weak or very weak biofilm, respectively. The effect of ZnO‐QDs on strong and moderate biofilms reveal that QDs could also inhibit and destroy biofilm produced by MRSA. In addition, the antibiofilm effect of ZnO‐QDs is greater than their antibacterial effect. Generally, this work offers new insights into the development of antibacterial and antibiofilm nanomaterials.

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Comparative study of zinc oxide nanoparticles synthesized through biogenic and chemical route with reference to antibacterial, antibiofilm and anticancer activities

Cited by 13 publications

References 31 publications

Therapeutic strategies for drug‐resistant Pseudomonas aeruginosa: Metal and metal oxide nanoparticles

Therapeutic strategies for drug‐resistant Pseudomonas aeruginosa: Metal and metal oxide nanoparticles

Inorganic nanoparticles: An effective antibiofilm strategy

Antibacterial and Antibiofilm Activity of Zinc Oxide Quantum Dots against Methicillin‐resistant Staphylococcus aureus

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