Comparative study of zopiclone, a novel hypnotic, and three benzodiazepines

Wickstrøm, E; Giercksky, Karl Erik

doi:10.1007/bf00562616

Cited by 33 publications

(7 citation statements)

References 3 publications

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“…The dose of zopiclone selected for this study (7.5 mg) has been shown to be effective as an hypnotic (Wickstrom & Giercksky, 1980), and furthermore, Lader & Denney (1983) reported this dose to be the preferred hypnotic dose.…”

Section: Introductionmentioning

confidence: 99%

Zopiclone produces effects on human performance similar to flurazepam, lormetazepam and triazolam.

Griffiths¹,

Jones²,

Richens³

1986

Brit J Clinical Pharma

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1 The cognitive function and psychomotor performance of 10 healthy male volunteers were measured following single oral doses of: zopiclone (7.5 mg), flurazepam (15 mg), lormetazepam (1 mg), triazolam (0.25 mg) and placebo. 2 The performance tests selected (stroop task, five choice serial reaction time, memory span, logical reasoning, mood and saccadic eye movement analysis) were thought to reflect aspects of normal daily activity. 3 The tests demonstrated a clear reduction of performance for all active treatments. No drug emerged as the most potent sedative overall, as each of the tests was affected to a different degree by each drug. 4 Drug effects were not qualitatively different between active treatments so that zopiclone was indistinguishable from the three benzodiazepines with which it was compared.

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Section: Introductionmentioning

confidence: 99%

Zopiclone produces effects on human performance similar to flurazepam, lormetazepam and triazolam.

Griffiths¹,

Jones²,

Richens³

1986

Brit J Clinical Pharma

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“…5]. It is possible that 2 mg of flunitrazepam is slightly superior to 7.5 mg of zopiclone in hypnotic potency [29], Our results confirm the findings of earlier studies in which motor impairment and EEG changes characteristic of benzodiazepines have been measurable up to 12-18 h after 1 and 2 mg of flunitrazepam orally [3,8,15]. Similar results have been obtained for other benzodiazepines, especially for those with long elimination half-life or with long-acting active metabolites [3,[22][23][24], and even for those with rapid elimination rate, e.g.. triazo lam and temazepam [15][16][17], provided that fairly high doses are used.…”

Section: Discussionmentioning

confidence: 99%

Drug-Alcohol Interactions on Psychomotor Skills: Zopiclone and Flunitrazepam

Seppαlä¹,

Nuotto²,

Dreyfus³

1983

Pharmacology

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Interaction between alcohol and zopiclone or flunitrazepam as well as the residual effects of both these hypnotics were studied in 20 normal male volunteers who received each 3 of 6 different drug and drink combinations according to a balanced incomplete block design as follows: placebo, zopiclone (7.5 mg), or flunitrazepam (2 mg) was administered double-blind in identical capsules at 23.00 h, and 0.5 g/kg body weight of alcohol or placebo alcohol was given at 08.30 h the following morning. Psychomotor skills of the volunteers were measured before drinking and 30 min, 1.5 h and 2.5 h after it. As compared with placebo, zopiclone had no residual effects, while flunitrazepam had some effects on standing steadiness, tracking, and flicker recognition. Alcohol alone had a non-significant effect on skills, and the combination zopiclone plus alcohol behaved as alcohol alone. Flunitrazepam plus alcohol impaired significantly standing steadiness, tracking, and reactive skills when compared with all other treatments. Time anticipation and hand and foot proprioception were not affected by any treatment. The results suggest that flunitrazepam, unlike zopiclone, has residual effects and interacts with alcohol in the morning following overnight ingestion of the drug.

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“…Zopiclone is a new hypnotic with a good hypnotic effect [9,10] and a plasma elimina tion half-life of about 5 h in younger patients which prolongs to about 7 h in geriatric pa tients [11]. The drug could, therefore, be ex pected to induce and maintain sleep in old patients with a minimum of influence on per formance the next day.…”

Section: ]mentioning

confidence: 99%

Zopiclone to Geriatric Patients

Dehlin¹,

Rundgren²,

Börjesson³

et al. 1983

Pharmacology

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Zopiclone was given for 14 nights to 68 geriatric patients (mean age 81 years) with sleep problems. The patients were randomly allocated to four treatment groups: 3.75 mg, 5.0, 7.5, or 10.0 mg of zopiclone. Sleep quantity and quality, side effects, and influence on psychomotor performance (digit symbol substitution and letter cancellation test) were studied before treatment, during active treatment, and after withdrawal of the drug. All patients slept better on zopiclone compared to placebo. There were only slight differences between the different dose levels as regards quantity and quality. No influence on psychomotor performance could be shown. The side effects were mild. Zopiclone showed a good hypnotic efficacy, and 7.5 mg is probably the best dose for elderly patients.

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Comparative study of zopiclone, a novel hypnotic, and three benzodiazepines

Cited by 33 publications

References 3 publications

Zopiclone produces effects on human performance similar to flurazepam, lormetazepam and triazolam.

Zopiclone produces effects on human performance similar to flurazepam, lormetazepam and triazolam.

Drug-Alcohol Interactions on Psychomotor Skills: Zopiclone and Flunitrazepam

Zopiclone to Geriatric Patients

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