Comparative Study on Co-Ground Products of Rofecoxib with  -Cyclodextrin and Its Sulfobutyl Ether-7 Derivative in Solution and in the Solid State

Rajendrakumar, Kale; Tayade, Pralhad; Madhusudan, Saraf

doi:10.1023/b:jiph.0000048314.41966.65

Cited by 7 publications

(1 citation statement)

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“…A number of studies on the complexation of bioactive molecules and drugs with CDs via the milling method have been published [36][37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

Efficient mechanochemical complexation of various steroid compounds with α-, β- and γ-cyclodextrin

et al. 2015

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Mechanochemical technology enables solvent-free micronized solid dispersions and efficient molecular host-guest inclusion complexes to be formed in matrices which contain cyclodextrins (CDs). This type of complexation has been studied using α-, β- and γ-cyclodextrin with the dual aims of improving overall solubility and enhancing the bioavailability of common steroid compounds, such as cholic acids and β-sitosterols or lowering cholesterol content in products of animal origin. Several parameters have been studied and optimized: CD/compound molar ratio (1:1, 1:2, 2:1 and 3:1) in function of the cavity sizes of the three different CDs, milling time (from 5 to 40 min) and rotation speed (from 100 to 300 rpm). DSC (differential scanning calorimetry) analyses have revealed that inclusion complexes were efficiently formed after 40 min milling (200 rpm) for β-CD/cholesterol and β-CD/ugrsodeoxycholic acid (encapsulation efficiency 96% and 77% respectively). Besides steroid encapsulation/vehiculation, the mechanochemical technique may pave the way for new ideas in solventless steroid extraction from vegetal matrices with CDs.

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“…A number of studies on the complexation of bioactive molecules and drugs with CDs via the milling method have been published [36][37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%