Comparative study on composition and antimicrobial activity of<i>Juniperus wallichiana</i>essential oils against clinical isolates

Haider, S. Zafar; Mohan, Manindra; Sah, Sunil; Seth, Richa

doi:10.5958/j.0975-6892.5.2.014

Cited by 1 publication

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“…Consult/2014/2424-03 GIT ailments and treatment (Haider et al, 2013) of urinary tract infections (Seca and Silva, 2006) Juniperus polycarpos (Moein et al, 2010) rheumatic arthritis and to relieve menstrual pain (Seca and Silva, 2006) Juniperus macropoda , 1984) cystitis (Baral and Kurmi, 2006) Juniperus indica (Dhupi) NISCAIR/RHMD/…”

Section: Black Junipermentioning

confidence: 99%

Identification and Characterization of Amentoflavone from Six Species of Juniperus Against H2O2 Induced Oxidative Damage in Human Erythrocytes and Leucocytes

Bais¹,

Prashar²

2015

Research J. of Phytochemistry

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The aim of the present study was to investigate the protective effects of amentoflavone (AF), isolated from six species of Juniperus (AF1-AF6) (Cupressaceae) Juniperus communis L. (AF1), Juniperus wallichiana L. (AF2), Juniperus indica L. (AF3), Juniperus macropoda L. (AF4), juniperus recurva L. (AF5) and Juniperus polycarpos L. (AF6)] against H 2 O 2 induced oxidative damage in human erythrocytes and leucocytes. The experiment was set and designed as per method available in literature. Amentoflavone was isolated from aerial parts of Juniperus species (above six) and authenticated by TLC, IR, HPLC and physicochemical parameters. The two concentration of isolated AF (A = 250 µL, B = 500 µL) were used to assessed its protective effects against H 2 O 2 induced oxidative damage in human erythrocytes and leucocytes. The measurements of different antioxidant parameters like, CAT, SOD and GPx, LPO and GSH levels were performed under each set extracts. Juniperus communis L. (AF1 B) (500 µL) and Juniperus indica L. (AF3 B) (500 µL) were the most significant one on CAT (28.35±2.980 and 27.73±1.580 AU gG 1 Hb), GPx (128.53±3.10 and 41.7±1.420 µg gG 1 Hb) and SOD (1193.5±19.7 and 1532.6±17.60 U gG 1 Hb) enzyme systems of erythrocytes. Among plant extracts, Juniperus communis L. (AF1 B) showed the highest activities on CAT (13.79±1.832 AU mgG 1 protein) and SOD (820±14.50 U mgG 1 protein) while Juniperus indica L. (AF3 B) showed significant effects on Gpx (152.72±3.70 U mgG 1 protein), GSH (25.93±1.560 µg mgG 1 protein) and LPO (10.54±2.90 nmol mgG 1 protein) enzyme systems of leucocytes. The study concludes that isolated fractions of AF from Juniperus species (among six species), has a potential source of natural antioxidants for treatment and prevention of diseases in which oxidative stress takes place.

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Section: Black Junipermentioning

confidence: 99%