Tungsten inert gas welding and vacuum brazing butt joints of Al-Mg-Si alloy 6061 in the artificially aged condition T6 were studied. Constant amplitude and variable amplitude fatigue loading tests were performed. The experimental S-N curves were compared with the fatigue design curves recommended by the International Institute of Welding, British Standard, and Eurocode 9. Two mean stress correction methods, Goodman and Gerber, were evaluated. In terms of the size effect on the fatigue life, this article proposed an innovational thickness correction method based on the ratio of the ultimate tensile strengths of specimens with different thickness. For vacuum brazing components, the tensile strengthbased thickness correction method was better than the thickness correction methods recommended by the International Institute of Welding and Eurocode 9.