Comparative study on protective effect of hydrogen rich saline and adipose-derived stem cells on hepatic ischemia-reperfusion and hepatectomy injury in swine

Zhang, Qianzhen; Piao, Chenxi; Xu, Jiayuan; Jiao, Zhen; Ge, Yansong; Liu, Xiaoning; Ma, Yajun; Wang, Hongbin

doi:10.1016/j.biopha.2019.109453

Cited by 16 publications

(19 citation statements)

References 46 publications

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“…A different study reported that ADSCs suppressed the level of inflammatory cytokines such as IL-1 β , IL-6, and TNF, while enhancing the secretion of the anti-inflammatory factor IL-10 and the regenerative factors HGF and cyclin D1, thereby ameliorating the IRI-induced damage [ 152 ]. Similar hepatoprotective effects were also found in other trials [ 153 ]. In a carbon tetrachloride- (CCl 4 -) induced acute liver injury model, Yan et al intravenously injected ADSCs to assess their effects on acute liver injury [ 154 ].…”

Section: Regenerative Medicine Based On Adscssupporting

confidence: 89%

Adipose-Derived Stem Cells: Current Applications and Future Directions in the Regeneration of Multiple Tissues

Zhang

Liu

Chen

et al. 2020

Stem Cells International

126

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Adipose-derived stem cells (ADSCs) can maintain self-renewal and enhanced multidifferentiation potential through the release of a variety of paracrine factors and extracellular vesicles, allowing them to repair damaged organs and tissues. Consequently, considerable attention has increasingly been paid to their application in tissue engineering and organ regeneration. Here, we provide a comprehensive overview of the current status of ADSC preparation, including harvesting, isolation, and identification. The advances in preclinical and clinical evidence-based ADSC therapy for bone, cartilage, myocardium, liver, and nervous system regeneration as well as skin wound healing are also summarized. Notably, the perspectives, potential challenges, and future directions for ADSC-related researches are discussed. We hope that this review can provide comprehensive and standardized guidelines for the safe and effective application of ADSCs to achieve predictable and desired therapeutic effects.

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Section: Regenerative Medicine Based On Adscssupporting

confidence: 89%

Adipose-Derived Stem Cells: Current Applications and Future Directions in the Regeneration of Multiple Tissues

Zhang

Liu

Chen

et al. 2020

Stem Cells International

126

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“…Recent studies have shown that ADSCs transplantation can attenuate liver IRI by reducing hepatocyte apoptosis (Ge et al, 2018a,b;Zhang et al, 2019). Furthermore, IR and partial hepatectomy injury triggers severe ERS via the PERK/eIF2α, IRE-1/XBP1 and ATF6 pathways, resulting in the accumulation of the ERS-related apoptosis protein CHOP.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have demonstrated a crucial role of ERS in hepatic ischemia-reperfusion (IR), which is inevitable in complex liver surgery and causes severe hepatocyte damage. Reduction of IR injury (IRI) is a major clinical challenge at present (Zhang et al, 2018(Zhang et al, , 2019Ge et al, 2019). IR is accompanied by hypoxia, glucose/nutrient depletion, ATP depletion, excessive free radical production and Ca 2+ imbalance, all of which can cause ER dysfunction and trigger ERS.…”

Section: Introductionmentioning

confidence: 99%

Adipose-Derived Stem Cells Protect Ischemia-Reperfusion and Partial Hepatectomy by Attenuating Endoplasmic Reticulum Stress

Jiao

Liu

et al. 2020

Front. Cell Dev. Biol.

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Ischemia-reperfusion (IR) is an inevitable complication of liver surgery. Recent studies indicate a critical role of endoplasmic reticulum stress (ERS) in hepatic IR. Mesenchymal stem cells (MSCs) have proven to be an effective tool for tissue regeneration and treatment of various diseases, including that of the liver. However, the mechanisms underlying the therapeutic effects of stem cells on hepatic IR injury (IRI) are still poorly understood, especially in the context of ERS. In this study, we established a porcine model of hepatic IRI and partial hepatectomy, and transplanted the animals with adipose-derived mesenchymal stem cells (ADSCs) isolated from miniature pigs. ADSCs not only alleviated the pathological changes in the liver parenchyma following IRI, but also protected the resident hepatocytes from damage. Mechanistically, the ADSCs significantly downregulated ERS-related proteins, including GRP78, p-eIF2α, ATF6 and XBP1s, as well as the proteins involved in ERS-induced apoptosis like p-JNK, ATF4 and CHOP. Taken together, ADSCs can alleviate hepatic IRI by inhibiting ERS and its downstream apoptotic pathways in the hepatocytes, indicating its therapeutic potential in liver diseases.

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“…This approach can significantly protect liver grafts from IRI [ 104 ], providing a potentially effective strategy for organ preservation. Other studies demonstrated the protective effects of H 2 in liver damage induced by parasites [ 105 ], obstructive jaundice [ 106 ], shock and resuscitation [ 107 ], sepsis [ 108 ], doxorubicin [ 6 ], and aflatoxin B1 [ 109 ]. In a mouse model of nonalcoholic fatty liver disease (NAFLD), HW downregulated Nrf2-mediated miR-136 expression by targeting the maternally expressed 3 long noncoding RNA gene [ 110 ], providing a rationale for further clinical trials.…”

Section: Preventive and Therapeutic Applications Of H 2 mentioning

confidence: 99%

Hydrogen: A Novel Option in Human Disease Treatment

Yang

Dong

et al. 2020

Oxidative Medicine and Cellular Longevity

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H2 has shown anti-inflammatory and antioxidant ability in many clinical trials, and its application is recommended in the latest Chinese novel coronavirus pneumonia (NCP) treatment guidelines. Clinical experiments have revealed the surprising finding that H2 gas may protect the lungs and extrapulmonary organs from pathological stimuli in NCP patients. The potential mechanisms underlying the action of H2 gas are not clear. H2 gas may regulate the anti-inflammatory and antioxidant activity, mitochondrial energy metabolism, endoplasmic reticulum stress, the immune system, and cell death (apoptosis, autophagy, pyroptosis, ferroptosis, and circadian clock, among others) and has therapeutic potential for many systemic diseases. This paper reviews the basic research and the latest clinical applications of H2 gas in multiorgan system diseases to establish strategies for the clinical treatment for various diseases.

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Comparative study on protective effect of hydrogen rich saline and adipose-derived stem cells on hepatic ischemia-reperfusion and hepatectomy injury in swine

Cited by 16 publications

References 46 publications

Adipose-Derived Stem Cells: Current Applications and Future Directions in the Regeneration of Multiple Tissues

Adipose-Derived Stem Cells: Current Applications and Future Directions in the Regeneration of Multiple Tissues

Adipose-Derived Stem Cells Protect Ischemia-Reperfusion and Partial Hepatectomy by Attenuating Endoplasmic Reticulum Stress

Hydrogen: A Novel Option in Human Disease Treatment

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