Comparative study on the interactions of cationic gemini and single-chain surfactant micelles with curcumin

Wan, Zizhen; Ke, Dan; Hong, Jinxiang; Ran, Qianping; Wang, Xiaoyong; Chen, Zhiyun; An, Xueqin

doi:10.1016/j.colsurfa.2012.08.046

Cited by 20 publications

(7 citation statements)

References 34 publications

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“…Thus, the degradation of Cur 3À can be expressed by a decrease of the characteristic absorption around 470 nm over time. Previous studies [13][14][15][16] on stabilizing Cur 3À emphasized that the surfactant concentrations used are at least twice the critical micelle concentration of the surfactant itself at neutral pH to ensure the formation of micelles for encapsulation. Actually, the added basic Cur 3À solution can effectively decrease the critical micelle concentration of surfactants as discussed above.…”

Section: Effect Of 12-6-12 Concentration On Stabilization Of Cur 3àmentioning

confidence: 99%

“…Wang et al 15 found that cationic gemini surfactants show higher efficacy in stabilizing Cur 3À at pH 13.0 than their monomeric counterparts. This is attributed to the fact that micelles formed by cationic gemini surfactants carry higher charge density than the monomeric counterparts, which leads to stronger electrostatic attraction with Cur 3À .…”

Section: Introductionmentioning

confidence: 99%

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Interactions of cationic trimeric, gemini and monomeric surfactants with trianionic curcumin in aqueous solution

Wang

Tang

et al. 2014

Soft Matter

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Interactions of trianionic curcumin (Cur(3-)) with a series of cationic surfactants, monomeric surfactant dodecyl trimethylammonium bromide (DTAB), dimeric surfactant hexamethylene-1,6-bis(dodecyldimethylammonium bromide) (12-6-12) and trimeric surfactant tri(dodecyldimethylammonioacetoxy)diethyltriamine trichloride (DTAD), have been investigated in aqueous solution of pH 13.0. Surface tension and spectral measurements indicate that the cationic surfactants display a similar surfactant concentration dependent interaction process with Cur(3-), involving three interaction stages. At first the three cationic surfactants electrostatically bind on Cur(3-) to form the surfactant-Cur(3-) complex. Then the bound and unbound cationic surfactants with Cur(3-) aggregate into surfactant-Cur(3-) mixed micelles through hydrophobic interactions above the critical micelle concentration of the surfactants (CMCC) in the presence of Cur(3-). Finally excess unbound surfactants self-assemble into micelles like those without Cur(3-). For all the three surfactants, the addition of Cur(3-) only decreases the critical micelle concentration of 12-6-12 but does not affect the critical micelle concentration of DTAB and DTAD. As the oligomeric degree of surfactants increases, the intermolecular interaction of the cationic surfactants with Cur(3-) increases and the surfactant amount needed for Cur(3-) encapsulation decreases. Compared with 12-6-12, either the weaker interaction of DTAB with Cur(3-) or stronger interaction of DTAD with Cur(3-) limits the stability or solubility of Cur(3-) in surfactant micelles. Therefore, gemini surfactant 12-6-12 is the best choice to effectively suppress Cur(3-) degradation at very low concentrations. Isothermal titration microcalorimetry, surface tension and (1)H NMR results reveal that 12-6-12 and Cur(3-) form a (12-6-12)2-Cur(3-) complex and start to form micelles at extremely decreased concentrations, where either 12-6-12 or Cur(3-) works as a bridge linkage and the resultant structure exhibits the characteristics of oligomeric surfactants.

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Section: Effect Of 12-6-12 Concentration On Stabilization Of Cur 3àmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interactions of cationic trimeric, gemini and monomeric surfactants with trianionic curcumin in aqueous solution

Wang

Tang

et al. 2014

Soft Matter

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“…The nanoscale materials are currently being investigated to improve their specificity towards cancer cells and towards subcellular compartments in order to reduce systemic toxicity [ 15 , 16 , 17 , 18 , 19 , 20 ]. Curcumin has also been developed in nanoscale [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. For example, Shaikh and coworkers (2009) [ 29 ] prepared curcumin-loaded poly(lactide-co-glycolide) (curcumin loaded PLGA) nanoparticles by using an emulsion–diffusion–evaporation method.…”

Section: Introductionmentioning

confidence: 99%

Design of Turmeric Rhizome Extract Nano-Formula for Delivery to Cancer Cells

et al. 2022

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Novel turmeric rhizome extract nanoparticles (TE-NPs) were developed from fractions of dried turmeric (Curcuma longa Linn.) rhizome. Phytochemical studies, by using HPLC and TLC, of the fractions obtained from ethanol extraction and solvent–solvent extraction showed that turmeric rhizome ethanol extract (EV) and chloroform fraction (CF) were composed mainly of three curcuminoids and turmeric oil. Hexane fraction (HE) was composed mainly of turmeric oil while ethyl acetate fraction (EA) was composed mainly of three curcuminoids. The optimal TE-NPs formulation with particle size of 159.6 ± 1.7 nm and curcumin content of 357.48 ± 8.39 µM was successfully developed from 47-run D-optimal mixture–process variables experimental design. Three regression models of z-average, d50, and d90 could be developed with a reasonable accuracy of prediction (predicted r2 values were in the range of 0.9120–0.9992). An in vitro cytotoxicity study using MTT assay demonstrated that the optimal TE-NPs remarkably exhibited the higher cytotoxic effect on human hepatoma cells, HepG2, when compared with free curcumin. This study is the first to report nanoparticles prepared from turmeric rhizome extract and their cytotoxic activity to hepatic cancer cells compared with pure curcumin. These nanoparticles might serve as a potential delivery system for cancer therapy.

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“…4). In this case, the interfacial tension value could be calculated from the slope according to (7), where the gravitational acceleration g and the aqueous phase depth are 9.81 m/s 2 and 0.010 m, respectively. The calculated interfacial tension value of 9.87 × 10 −4 mN/m was obtained.…”

Section: Theoretical Considerationsmentioning

confidence: 99%

“…Thus there is a limitation for its use as a therapeutic agent. Various techniques were proposed to improve the efficacy of curcumin, for example, micelle [6][7][8] , liposome 9 , microemulsion [10][11][12] , nanoemulsion 13,14 , nanoparticles 15,16 , nanocapsules [17][18][19] , self-assembling peptide hydrogel 20 , or solid lipid particle 21 . Microemulsion is a colloidal system of two immiscible liquids in which droplet formation requires low energy or occurs spontaneously 22 .…”

Section: Introductionmentioning

confidence: 99%

Interfacial tension of turmeric nanoparticles

Auychaipornlert¹,

Lawanprasert²,

Piriyaprasarth³

et al. 2018

ScienceAsia

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ABSTRACT:The dried rhizome of turmeric (Curcuma longa) is a source of volatile oil and curcuminoids. Curcumin, the major component, has a wide spectrum of pharmacological activities. Various advanced techniques have been proposed to improve the efficacy of curcumin, especially nanoparticles formation techniques. In this study, we prepared turmeric spherical particles in an alcoholic water system to investigate their physicochemical properties. Turmeric spherical particles were in a nanometre size range with a narrow size distribution and negative surface charge. Additionally, we proposed an equation derived from the Young-Laplace equation which appears to be applicable to estimate an interfacial tension value of turmeric nanoparticles and other microemulsion systems.

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Comparative study on the interactions of cationic gemini and single-chain surfactant micelles with curcumin

Cited by 20 publications

References 34 publications

Interactions of cationic trimeric, gemini and monomeric surfactants with trianionic curcumin in aqueous solution

Interactions of cationic trimeric, gemini and monomeric surfactants with trianionic curcumin in aqueous solution

Design of Turmeric Rhizome Extract Nano-Formula for Delivery to Cancer Cells

Interfacial tension of turmeric nanoparticles

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