The thermophysical properties of a working-fluid play an important role in the process of stirring-heating. The heating process of stirring is accompanied by two processes: the friction between the solid mechanism and the working-fluid and the viscous dissipation of the working liquid. Traditionally, the sensible heat of water-based working-fluids is low, while that of oil-based working-fluids is higher, but the load capacity is relatively low. In order to find a balance between the two, an optimal stirring working-fluid should be selected. In this study, an experimental method was used to study the heating process of 30 kinds of working-fluids. The numerical evaluation model of the effects of thermophysical properties on the comprehensive evaluation index of heat (CEIH) was established by multiple linear regression methods, and a computational fluid dynamics (CFD) tool was used to analyze the heat generation and flow field of different working-fluids in the stirring-heating device. The results show that viscous dissipation is the most important way of stirring-heating. CFD can completely replace the experiment to study the heating effect of stirring. The thermophysical properties of the working-fluid affect the upper circulation and the overall velocity of the double circulation flow. The experimental results and regression model analysis show that specific heat capacity has the greatest effect on the heating effect, but density will also play a positive role in the stirring-heating. Water-based salt solutions such as KCl can achieve a better heating effect, and oil-based working-fluids are not always the best choice.