Comparative study on the properties of a bio-based copolymacrolactone system

Chiriac, Aurica P.; Asăndulesa, Mihai; Stoica, Iuliana; Tudorachi, Niță; Rusu, Alina Gabriela; Niţă, Loredana E.; Chiriac, Vlad Mihai; Ţîmpu, Daniel

doi:10.1016/j.polymertesting.2022.107555

Cited by 9 publications

(14 citation statements)

References 44 publications

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“…Two variants of PEBSA copolymacrolactone were synthesised. The copolymer variant obtained in solution and coded PEBSA_solution was synthesised as previously presented [ 2 , 20 , 21 ]. Briefly, the ring opening of EB and polycondensation with SA (comonomers in a molar ratio of 75/25 EB/SA) took place in a homogeneous system of 1, 4 dioxane, and using 1-hexanol as an initiator (in 10/1 ratio related to EB content).…”

Section: Methodsmentioning

confidence: 99%

“…The most widely used method of obtaining polyesters from macrolactone is ring-opening polymerisation (ROP) performed catalytically or enzymatically, in bulk, solution, emulsion, or suspension. At the same time, the differences should be noted between the conditions of ring-opening polymerisation between small lactones and macrolactones that are caused by little or no ring strain in the case of the compounds with 12 or more atoms, which requires specific catalysts to obtain optimal yields [ 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. Recently, one of the most studied macrolactones that is of particular interest is ethylene brassylate (EB), a 17-membered lactone ring, investigated essentially by ring-opening polymerisation [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Preparation of an Antioxidant Assembly Based on a Copolymacrolactone Structure and Erythritol following an Eco-Friendly Strategy

Chiriac¹,

Ghilan²,

Șerban³

et al. 2022

Antioxidants

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The study presents the achievement of a new assembly with antioxidant behaviour based on a copolymacrolactone structure that encapsulates erythritol (Eryt). Poly(ethylene brassylate-co-squaric acid) (PEBSA) was synthesised in environmentally friendly conditions, respectively, through a process in suspension in water by opening the cycle of ethylene brassylate macrolactone, followed by condensation with squaric acid. The compound synthesised in suspension was characterised by comparison with the polymer obtained by polymerisation in solution. The investigations revealed that, with the exception of the molecular masses, the compounds generated by the two synthetic procedures present similar properties, including good thermal stability, with a Tpeak of 456 °C, and the capacity for network formation. In addition, the investigation by dynamic light scattering techniques evidenced a mean diameter for PEBSA particles of around 596 nm and a zeta potential of −25 mV, which attests to their stability. The bio-based copolymacrolactone was used as a matrix for erythritol encapsulation. The new PEBSA–Eryt compound presented an increased sorption/desorption process, compared with the PEBSA matrix, and a crystalline morphology confirmed by X-ray diffraction analysis. The bioactive compound was also characterised in terms of its biocompatibility and antioxidant behaviour.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation of an Antioxidant Assembly Based on a Copolymacrolactone Structure and Erythritol following an Eco-Friendly Strategy

Chiriac¹,

Ghilan²,

Șerban³

et al. 2022

Antioxidants

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“…According to our investigations, the PEBSA variants have two to three stages of thermal degradation depending on the molar ratio between the comonomers, and start from 260 °C to a maximum degradation temperature of 460 °C [ 12 ]. Considering that, in previous studies [ 12 ], the thermal analysis was performed on all three variants of copolymers, with the studies showing the appearance of differences only in the case of PEBSA 50/50 , in this paper, this variant was studied in thermal analysis of the obtained cryogels.…”

Section: Resultsmentioning

confidence: 99%

“…These differences are associated with the increase in the number of carbonyl functional groups and resulting in growth of hydrogen bonds number [ 12 ]. Thus, the pore size and shape of PVA/PEBSA cryogels can be modified by adjusting the ratio between EB and SA comonomers from PEBSA composition, thus, providing the flexibility in the preparation of cryogels with the desired properties for the targeted application.…”

Section: Resultsmentioning

confidence: 99%

“…Our group reported recently the synthesis of poly(ethylene brassylate-co-squaric acid) (PEBSA) performed by ethylene brassylate macrolactone ring-opening and copolycondensing with squaric acid [ 11 ]. In previous studies, our group paid particular attention to this copolymeracrolactone system with different ratios between comonomers [ 11 , 12 , 13 ]. PEBSA, which presents special properties, such as the possibility to create networks, biodegradability and good thermal stability, is also capable of incorporating essential oils—namely thymol (Thy) and carvacrol (CC).…”

Section: Introductionmentioning

confidence: 99%

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New Cryogels Based on Poly(vinyl alcohol) and a Copolymacrolactone System: I-Synthesis and Characterization

Crețu¹,

Niţă²,

Șerban³

et al. 2022

Nanomaterials

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Physical cryogels were obtained using the successive freeze–thaw technique of poly(vinyl alcohol) (PVA)/poly(ethylene brassylate-co-squaric acid) (PEBSA) solutions. The cryogel systems were prepared by using two different molecular weights of PVA and PEBSA with three different ratios between the ethylene brassylate (EB) and squaric acid (SA) comonomers. The presence of interactions, the thermal properties and the morphology were investigated using Fourier Transform Infrared Spectroscopy (FT-IR), thermogravimetry (TGA and DTG) and scanning electron microscopy (SEM), respectively. The influence of the composition on the degree of swelling in a physiological environment was demonstrated. The study highlighted improvements in terms of new network flexibility due to the intermolecular chains interactions brought by the introduction of PEBSA in the cryogel structure. We also concluded that the presence of PEBSA in the PVA/PEBSA cryogel network improved the loading capacity of the new system with specific hydrophobic agents, for example essential oils, which (due to their antimicrobial character) can lead to the use of new systems obtained for various applications.

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Hydrogels with Antioxidant Microparticles Systems Based on Hyaluronic Acid for Regenerative Wound Healing

Nacu,

Ghilan,

Rusu

et al. 2024

Macromolecular Bioscience

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This research focuses on the synthesis of hydrogels exhibiting enhanced antioxidant properties derived from hyaluronic acid (HA) and poly(ethylene brassylate‐co‐squaric acid) (PEBSA), a copolymacrolactone that have the ability to be used in drug delivery applications. Quercetin (Q), a bioflavonoid with strong antioxidant properties, is employed as a bioactive compound. The biomolecule is encapsulated in the polymeric network using different entrapment techniques, including the initial formation of a complex between PEBSA and Q, which is demonstrated through the dynamic light scattering technique. Fourier transform infrared spectroscopy (FT‐IR) and rheological studies confirm the formation of the hydrogels, revealing the occurrence of physical interactions between the synthetic polymer and the polysaccharide. Moreover, the hydrogels demonstrate biocompatible properties after direct contact with the HDFa cell line and antioxidant properties, as revealed by DPPH tests.

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Comparative study on the properties of a bio-based copolymacrolactone system

Cited by 9 publications

References 44 publications

Preparation of an Antioxidant Assembly Based on a Copolymacrolactone Structure and Erythritol following an Eco-Friendly Strategy

Preparation of an Antioxidant Assembly Based on a Copolymacrolactone Structure and Erythritol following an Eco-Friendly Strategy

New Cryogels Based on Poly(vinyl alcohol) and a Copolymacrolactone System: I-Synthesis and Characterization

Hydrogels with Antioxidant Microparticles Systems Based on Hyaluronic Acid for Regenerative Wound Healing

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