Comparative study on two kidney graft rinsing and preservation solutions in terms of the post-transplantation risk of delayed graft function and cost

Vincentelli, J; Luccioni, Aline; Devictor, B; Dussol, Bertrand; Lechevallier, É.; Bertault-Péres, P; Coulange, C.; Berland, Yvon; Ragon, C Penot

doi:10.1046/j.1365-2710.2003.00489.x

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…Overall, the data supported our previous work, 13 and that of others, 21 which showed that EC was least able to control ischemic damage. The use of EC was coincident to the greatest increase in kidney weight during reperfusion.…”

Section: Discussionsupporting

confidence: 91%

Comparative efficacy of renal preservation solutions to limit functional impairment after warm ischemic injury

Ahmad

Pratt

Potts

et al. 2006

Kidney International

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In kidney transplantation, cold storage is the dominant modality used to prolong organ viability ex vivo, but is inevitably followed by a period of warm ischemia. Preservation fluids limit tissue damage during the ischemic period, but there is little information on the influence of preservation fluids on the physiologic consequences of warm ischemia alone, or on the comparative ability of such preservation fluids to limit warm ischemic injury. In this study, warm ischemia was induced in rat kidneys by crossclamping the left renal pedicle for 45 min with contralateral nephrectomy. The ischemic kidneys were flushed with Euro-Collins (EC), hyper osmolar citrate (HOC), University of Wisconsin (UW), or phosphate buffered sucrose (PBS)140 solution. Over a period of 2 h after reperfusion, urine and blood samples were collected and physiological parameters related to the function of the postischemic kidneys were assessed. The data show that postischemic renal function can be influenced by the choice of preservation fluid. Essentially, the continued use of EC as a renal preservation solution finds little support in these data, and, while HOC and UW solutions were better able to limit the decline in renal function after warm ischemia than EC, the solution most able to limit functional impairment after warm ischemia was PBS140. This analysis compares the efficacies of the commonly used preservation solutions and could form the basis for future solid-organ transplant studies that may ultimately allow us to propose best-practice guidelines and an optimum platform for improved preservation solutions.

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Section: Discussionsupporting

confidence: 91%

Comparative efficacy of renal preservation solutions to limit functional impairment after warm ischemic injury

Ahmad

Pratt

Potts

et al. 2006

Kidney International

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“…The other four citations reported one study which compared ViaSpan preservation solution with HTK 66 and two studies which compared ViaSpan with Euro Collins. 67,68 These four papers/abstracts were therefore not relevant to the comparator technologies of interest in this review, and were excluded from further detailed appraisal. However, they were retrieved and studied for any insights about methods or data sources they might provide.…”

Section: Resultsmentioning

confidence: 99%

“…We also examined a number of economic studies which compared alternative methods of kidney storage. 67,68,70,77 Another older study, by Hornberger and colleagues, 78 has also highlighted the potential importance for cost-effectiveness analyses of including re-transplantation as a treatment pathway.…”

Section: Other Relevant Studies Foundmentioning

confidence: 99%

The effectiveness and cost-effectiveness of methods of storing donated kidneys from deceased donors: a systematic review and economic model

Bond

Pitt²,

Akoh³

et al. 2009

Health Technol Assess

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The conclusions drawn for the comparison of machine perfusion with cold storage depend on which trial data are used in the model. Owing to the lack of good research evidence that either ViaSpan or Soltran is better than the other, the cheaper, Soltran, may be preferable. In the absence of a cost-utility analysis, the results of our meta-analysis of the RCTs comparing ViaSpan with Celsior indicate that these cold storage solutions are equivalent. Further RCTs of comparators of interest to allow for appropriate analysis of subgroups and to determine whether either of the two machines under consideration produces better outcomes may be useful. In addition, research is required to: establish the strength and reliability of the presumed causal association between DGF and graft, and patient survival; investigate the utility impacts of renal replacement therapy; determine what the additional cost, survival and QALY impacts are of decreased or increased non-viable kidneys when discarded pre transplantation; and identify a reliable measure for predicting kidney viability from machine perfusion.

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Tooth Replantation After Use of Euro-Collins Solution or Bovine Milk as Storage Medium: A Histomorphometric Analysis in Dogs

Sottovia

Filho

Poi

et al. 2010

Journal of Oral and Maxillofacial Surgery

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Comparative study on two kidney graft rinsing and preservation solutions in terms of the post-transplantation risk of delayed graft function and cost

Cited by 5 publications

References 10 publications

Comparative efficacy of renal preservation solutions to limit functional impairment after warm ischemic injury

Comparative efficacy of renal preservation solutions to limit functional impairment after warm ischemic injury

The effectiveness and cost-effectiveness of methods of storing donated kidneys from deceased donors: a systematic review and economic model

Tooth Replantation After Use of Euro-Collins Solution or Bovine Milk as Storage Medium: A Histomorphometric Analysis in Dogs

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