Comparative Tableting and Microstructural Properties of a New Starch for Direct Compression

Perales, Manuel; Muñoz‐Ruiz, Angel; Antequera, M. V. Velasco; Muñoz, Nydia; Ballesteros, María Rosa Jiménez-Castellanos

doi:10.3109/03639049609063225

Cited by 8 publications

(1 citation statement)

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“…Excipients can be modified by manufacturing process to produce new grades of the present excipients, for example the modification of starch to become soluble or spray dried lactose to assist its followability [ 5 ]. Common excipients are modified by coprocessing with other excipients in order to offer excipients with added advantages.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Three Chitin Metal Silicate Co-Precipitates as a Potential Multifunctional Single Excipient in Tablet Formulations

Hamid

Al-Akayleh²,

Shubair³

et al. 2010

Marine Drugs

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The performance of the novel chitin metal silicate (CMS) co-precipitates as a single multifunctional excipient in tablet formulation using direct compression and wet granulation methods is evaluated. The neutral, acidic, and basic drugs Spironolactone (SPL), ibuprofen (IBU) and metronidazole (MET), respectively, were used as model drugs. Commercial Aldactone®, Fleximex® and Dumazole® tablets containing SPL, IBU and MET, respectively, and tablets made using Avicel® 200, were used in the study for comparison purposes. Tablets of acceptable crushing strength (>40 N) were obtained using CMS. The friability values for all tablets were well below the maximum 1% USP tolerance limit. CMS produced superdisintegrating tablets (disintegration time < 1 min) with the three model drugs. Regarding the dissolution rate, the sequence was as follow: CMS > Fleximex® > Avicel® 200, CMS > Avicel® 200 > Dumazole® and Aldactone® > Avicel® 200 > CMS for IBU, MET and SPL, respectively. Compressional properties of formulations were analyzed using density measurements and the compression Kawakita equation as assessment parameters. On the basis of DSC results, CMS co precipitates were found to be compatible with the tested drugs. Conclusively, the CMS co-precipitates have the potential to be used as filler, binder, and superdisintegrant, all-in-one, in the design of tablets by the direct compression as well as wet granulation methods.

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Section: Introductionmentioning

confidence: 99%