Comparative three-dimensional analysis of CT-scans of the calvaria and cranial base in Apert and Crouzon syndromes

Kreiborg, Sven; Marsh, Jeffrey L.; Cohen, Michael; Liversage, Martin; Pedersen, H.; Skovby, Flemming; Børgesen, S. E.; Vannier, Michael W.

doi:10.1016/s1010-5182(05)80478-0

Cited by 169 publications

(104 citation statements)

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“…Cranial base anomalies have been identified in Down syndrome, Turner syndrome, craniosynostosis syndromes, cleidocranial dysplasia, and many other pathologic conditions. [8][9][10][11][12] In some cases, the cranial base anomaly is believed to be the primary cause that leads to the overall abnormal craniofacial development. 9 Concurring with this, animal studies provide experimental evidence that cranial base fusion alone accounts for many craniofacial dysmorphic features.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10][11][12] In some cases, the cranial base anomaly is believed to be the primary cause that leads to the overall abnormal craniofacial development. 9 Concurring with this, animal studies provide experimental evidence that cranial base fusion alone accounts for many craniofacial dysmorphic features. 13 Although the genetic mechanisms of development and growth are starting to be elucidated in many structures, very little is known regarding these mechanisms in the cranial base.…”

Section: Introductionmentioning

confidence: 99%

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Developmentally Regulated Expression of Msx1, Msx2 and Fgfs in the Developing Mouse Cranial Base

Nie

2006

The Angle Orthodontist

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Objective: To examine the expression pattern of the Fgf and Msx genes in cranial base development. Materials and Methods:To detect the expression of these genes, antisense riboprobes were synthesized by in vitro transcription. Radioactive in situ hybridization was performed on parasagittal sections of embryonic mouse heads. Results: Msx2 was observed in the underlying perichondrium at restricted stages. Msx1 was not observed in cranial base development. Fgf1 was localized in osteogenic cells from the time of ossification; Fgf10 was highly expressed in the occipital-vertebral joint during E13 to E14; Fgf2, Fgf7, and Fgf18 were localized in the perichondria; Fgf12 was transitorily expressed at early chondrocranium; Fgf9 was seen in the hypertrophic chondrocytes. Conclusions:The Fgf and Msx gene expression in the cranial base was different from that of other skeletons.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Developmentally Regulated Expression of Msx1, Msx2 and Fgfs in the Developing Mouse Cranial Base

Nie

2006

The Angle Orthodontist

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“…The present study showed that frontal bone had 2.4+_0.8 mm thick outer models. 2 Hemmy DC and Tessier P studied CT of dry skulls with craniofacial deformities and assessed accuracy of three-dimensional reconstruction.In this study dry skulls from patients with Crouzon syndrome or orbital neurofibromatosis were studied using threedimensional reconstruction of computed tomography data. The images were compared with one another and with the actual skulls.…”

Section: Discussionmentioning

confidence: 99%

Radiological Mapping Of Nepalese Calvaria.

Bhattarai¹

2013

J Nobel Med Coll

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“…7,8 According to Arvier et al 9 patients who could handle a model of themselves while the proposed treatment was explained, could understand their treatment better and were more likely to undergo the surgical procedure. Hjalgrim et al 10 described CT scanning and model production of an Egyptian mummy from the Roman cemetery of Hawara in ElFaijum, Egypt (circa first century AD).…”

Section: Introductionmentioning

confidence: 99%