Comparative tissue distribution and excretion of [1-14C]acrylamide in beagle dogs and miniature pigs

Ikeda, George J.; Miller, E.; Sapienza, P.P.; Michel, T.C.; Inskeep, Philip B.

doi:10.1016/0278-6915(87)90267-5

Cited by 31 publications

(21 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18 There are also large differences in metabolism rates across species. 17 Adding to the complexity, the mode of exposure between animals and humans differs, and we currently do not know about the bioavailability of acrylamide in foods. While evidence from animal 11,19 and risk assessment models 6,28 suggests a small increase in risk in humans, risk assessment models have generally assumed a linear dose-response relation at low levels of exposure, 29 but this is not known for certain.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prospective study of dietary acrylamide and risk of colorectal cancer among women

Mucci

Adami

Wolk

2005

Intl Journal of Cancer

View full text Add to dashboard Cite

There has been considerable discourse about whether exposure to acrylamide in foods could increase the risk of human cancer. Acrylamide is classified as a probable human carcinogen, and animal studies have demonstrated an increased incidence of tumors in rats exposed to very high levels. Still, epidemiologic data of the effect of dietary acrylamide remain scant. We have undertaken the first prospective study of acrylamide in food and risk of colon and rectal cancers using prospective data from the Swedish Mammography Cohort. The cohort comprised 61,467 women at baseline between 1987 and 1990. Through 2003, the cohort contributed 823,072 person-years, and 504 cases of colon and 237 of rectal cancer occurred. Mean intake of acrylamide through diet was 24.6 lg/day (Q25-70 5 18.7-29.9). Coffee (44%), fried potato products (16%), crisp bread (15%) and other breads (12%) were the greatest contributors. After adjusting for potential confounders, there was no association between estimated acrylamide intake and colorectal cancer. Comparing extreme quintiles, the adjusted relative risks (95% CI; p for trend) were for colorectal cancer 0.9 (0.7-1.3; p 5 0.80), colon cancer 0.9 (0.6-1.4; p 5 0.83) and rectal cancer 1.0 (0.6-1.8; p 5 0.77). Furthermore, intake of specific food items with elevated acrylamide (e.g., coffee, crisp bread and fried potato products) was not associated with cancer risk. In this large prospective study, we found no evidence that dietary intake of acrylamide is associated with cancers of the colon or rectum. Epidemiologic studies play an important role in assessing the possible health effects of acrylamide intake through food. ' 2005 Wiley-Liss, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

“…17,18 Lifetime oncogenicity studies have demonstrated an increased incidence of intestinal tumors among rats exposed to 2-3 mg acrylamide per day. 19 Understanding whether dietary acrylamide intake increases colorectal cancer risk among humans is warranted, particularly in light of the burden of this disease.…”

mentioning

confidence: 99%

Prospective study of dietary acrylamide and risk of colorectal cancer among women

Mucci

Adami

Wolk

2005

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Acrylamide in food occurs at 120 °C or higher temperatures as a result of Maillard reaction between monosaccharides such as fructose or glucose and amino acids such as asparagine (7). The studies show that acrylamide is absorbed in a very rapid and effective manner by means of gastrointestinal system (8,9).…”

Section: Introductionmentioning

confidence: 99%

The protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues

Altınöz¹,

Türköz²,

Vardı³

2015

BLL

View full text Add to dashboard Cite

Abstract:The aim of this study was to investigate the protective effects of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues in rats. The rats were divided into four groups. Acrylamide administration increased MDA levels in all tissues significantly (p < 0.05). But acrylamide+NAC administration decreased MDA levels signifi cantly as compared to the acrylamide group, and lowered it to a level close to the control group values (p < 0.05). GSH levels in liver and small intestine tissues reduced signifi cantly in the acrylamide group (p < 0.05). But acrylamide+NAC administration increased GSH levels signifi cantly in all tissues. Whereas GST activity decreased signifi cantly in the acrylamide group in liver and small intestine tissues as compared to the other groups (p < 0.05), the GST activity increased signifi cantly in the acrylamide+NAC group in all tissues as compared to the acrylamide group (p < 0.05). Liver histopathology showed that the liver epithelial cells were damaged signifi cantly in the acrylamide group. Small intestine histopathology showed that the intestinal villous epithelial cells were damaged signifi cantly in the acrylamide group. Our results indicate that a high level of acrylamide causes oxidative damage in liver and small and large intestine tissues, while N-acetylcysteine administration in a pharmacological dose shows to have an antioxidant effect in preventing this damage (Tab. 2, Fig. 2, Ref. 66). Text in PDF www.elis.sk.

show abstract

“…The monomer is distributed widely throughout the body and metabolized by the liver to non-toxic metabolites, which are mainly excreted in the urine 9 . Studies have demonstrated rapid and large-scale absorption in dogs after oral intake of acrylamide 6 . The resulting neuropathy and the severity of the syndrome that follows intoxication are dependent on the magnitude of the dose, the rate of administration and the period of exposure to the toxin 11 .…”

Section: Acrylamide Toxicitymentioning

confidence: 99%

“…Although the nervous system is the primary target for the acrylamide monomer, less than 1 % of the substance was detected in the brain. Neuropathy was observed in the dogs and pigs when the acrylamide was administered at 5 mg/kg/ day for an extended period of 30 to 60 days 6 . Chronic exposure in dogs leads to the typical progressive sensorimotor peripheral neuropathy, including toe cuffing and ataxia and weakness, with a unique association to megaoesophagus due to vagal nerve axonopathy 12 .…”

Section: Acrylamide Toxicitymentioning

confidence: 99%

Should veterinarians consider acrylamide that potentially occurs in starch-rich foodstuffs as a neurotoxin in dogs?

Roux-Pullen

Lessing²

2011

J. S. Afr. Vet. Assoc.

View full text Add to dashboard Cite

Three clinically healthy Labrador puppies developed ataxia, hypermetria and convulsions shortly after eating the burnt crust of maize porridge. Two of the puppies died. Acrylamide toxicity was considered based on the history of all 3 puppies developing nervous signs after being exposed to a starch-based foodstuff that was subjected to high temperature during preparation. Acrylamide-induced neurotoxicity is thought to partially result from a distal axonopathy

show abstract

Comparative tissue distribution and excretion of [1-14C]acrylamide in beagle dogs and miniature pigs

Cited by 31 publications

References 8 publications

Prospective study of dietary acrylamide and risk of colorectal cancer among women

Prospective study of dietary acrylamide and risk of colorectal cancer among women

The protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues

Should veterinarians consider acrylamide that potentially occurs in starch-rich foodstuffs as a neurotoxin in dogs?

Contact Info

Product

Resources

About