Comparative toxicity of 24 manufactured nanoparticles in human alveolar epithelial and macrophage cell lines

Lanone, Sophie; Rogerieux, Françoise; Geys, Jorina; Dupont, Aurélie; Maillot-Maréchal, Emmanuelle; Boczkowski, Jorge; Lacroix, Ghislaine; Hoet, Peter

doi:10.1186/1743-8977-6-14

Cited by 421 publications

(293 citation statements)

References 28 publications

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“…However, its toxicity reduces in AuNPs treated with CMCS. In this study, Au + decreased mitochondrial activity more than AuNPs with almost two fold difference in IC 50 values as shown in Table 2, which agreed with previous studies of many researcher [25][26][27][28] MTT assay used to measure the cell viability expressed in the decrease in mitochondrial activity (Table3). A reduction in mitochondrial function of A549 cells exposed to the three GNPs types prepared.…”

Section: Figure 4:-sem and Edx Spectra Cotton Treated With Aunpssupporting

confidence: 91%

Green Synthesis, Cytotoxicity and Utilization of Carboxymethylchitosan-Stabilized Gold Nanoparticles.

Ibrahim¹,

Dakrory²,

Tawfik³

et al. 2017

IJAR

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Section: Figure 4:-sem and Edx Spectra Cotton Treated With Aunpssupporting

confidence: 91%

Green Synthesis, Cytotoxicity and Utilization of Carboxymethylchitosan-Stabilized Gold Nanoparticles.

Ibrahim¹,

Dakrory²,

Tawfik³

et al. 2017

IJAR

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“…7 Furthermore, among 24 manufactured nanoparticles, which were compared for their toxicity in vitro in human alveolar epithelial and macrophage cell lines, copper-and zinc-based nanoparticles appeared to be the most toxic, especially for human macrophages. 26 In this connection, the particle size seems to have an important role, for human epithelial cells, it was shown that nanoparticles of CuO were much more toxic compared with micrometer particles of CuO. 27 Although the median for the SAA increases after inhalation of zinc-containing welding fume is lower than the respective median after inhalation of "copper only" welding fume, the elevations of SAA are relatively high in some cases.…”

Section: Discussionmentioning

confidence: 99%

Systemic serum amyloid A as a biomarker for exposure to zinc and/or copper-containing metal fumes

Baumann

Gube

Markert

et al. 2017

J Expo Sci Environ Epidemiol

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Zinc-and copper-containing welding fumes increase systemic C-reactive protein (CRP). The aim of this study was to investigate the performance of the biomarkers serum amyloid A (SAA) and soluble vascular cell adhesion molecule-1 (VCAM-1) in this regard. Fifteen male subjects were exposed under controlled conditions to welding fumes containing either zinc, or copper, or copper and zinc for 6 h. Plasma samples were collected before, 6 and 24 h after start of exposure and biomarkers therein were measured by electrochemiluminescent assay. For each exposure, systemic concentrations of systemic SAA, but not VCAM-1, increased significantly at 24 h after exposure start compared with baseline ("copper only": P = 0.0005, "zinc only": P = 0.027, "copper and zinc": P = 0.001). SAA showed a wider range of concentrations than did CRP and its levels increased up to 19-fold after welding fume exposure. The recognition of copper as a potential harmful component in welding fumes, also independent from zinc, deserves further consideration. SAA might represent a new sensitive biomarker for potential subclinical sterile inflammation after inhalation of copper-and/or zinc-containing welding fumes. As elevations of CRP and SAA protein have both been linked to a higher risk for cardiovascular disease, these findings might particularly be important for long-term welders. Journal of Exposure Science and Environmental Epidemiology INTRODUCTIONA large number of workers are exposed to welding fumes containing various types of gases and metal particles in occupational settings. Depending on the constitution of the welding fumes and the respective exposure conditions, epidemiological studies have shown that welding fume exposure is associated with the risk of health impairment through respiratory illness, inflammation and cardiovascular disease. [1][2][3][4] Zinc and copper play an increasing role in modern joining technology, especially in the automotive industry, and hence exposures from workers become more frequent. In a recent study, a distinct increase of systemic C-reactive protein (CRP) has been shown after inhalation of welding fume from a metal inert gas brazing process of zinc-coated steel using a copper-containing welding wire at an average fume concentration of 2.5 mg/m 3 . 5 A further study tested the effect of elevated systemic CRP levels after exposure with three different doses of this welding fume and found increases of CRP after exposure with 2.0 and 2.5 mg/m 3 average fume concentration, but not at 1.4 mg/m 3 . Hence, it was concluded that the no-observed-effect level for systemic inflammation after such exposures was 1.4 mg/m 3 and the lowest observed effect level was 2.0 mg/m 3 . 6 This corresponds to zinc concentrations of 0.84 mg/m 3 and 1.2 mg/m 3 , respectively, and copper concentrations of 0.24 mg/m 3 and 0.34 mg/m 3 , respectively. 6 A subsequent third study showed that the observed effects were due to the zinc as well as copper present in the welding fume, as the welding fumes which contained either zinc and no cop...

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“…With frequent exposure to dispersed nanoparticles from the composite products or workplaces, there is an increased chance for nanoparticles or nano composites to enter human body and to relocate in metabolism-active organs (Song et al 2009). Thus, studying the toxicity of nanomaterials is of importance to provide the guidance to occupational health and safety (Li et al 2008;Lanone et al 2009;Turkez et al 2013a). The discussion about safety concerns associated with small particles is ongoing for many decades and, to a large extent, is related to the potential risks following inhalative, oral, parenteral or dermal exposure ).…”

Section: Introductionmentioning

confidence: 99%

The Risk Evaluation of Tungsten Oxide Nanoparticles in Cultured Rat Liver Cells for Its Safe Applications in Nanotechnology

Türkez

Sönmez

Turkez

et al. 2014

Braz. arch. biol. technol.

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Comparative toxicity of 24 manufactured nanoparticles in human alveolar epithelial and macrophage cell lines

Cited by 421 publications

References 28 publications

Green Synthesis, Cytotoxicity and Utilization of Carboxymethylchitosan-Stabilized Gold Nanoparticles.

Green Synthesis, Cytotoxicity and Utilization of Carboxymethylchitosan-Stabilized Gold Nanoparticles.

Systemic serum amyloid A as a biomarker for exposure to zinc and/or copper-containing metal fumes

The Risk Evaluation of Tungsten Oxide Nanoparticles in Cultured Rat Liver Cells for Its Safe Applications in Nanotechnology

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