Comparative toxicity of silver nanoparticle and ionic silver in juvenile common carp (Cyprinus carpio): Accumulation, physiology and histopathology

Khosravi-Katuli, Kheyrollah; Shabani, Ali; Paknejad, Hamed; Imanpoor, Mohammad Reza

doi:10.1016/j.jhazmat.2018.07.064

Cited by 69 publications

(19 citation statements)

References 41 publications

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“…As a result, various studies have been designed to assess the effect of even low doses of silver nanoparticles (AgNPs) on bacterial cell membranes [ 30 , 31 , 32 ]. Results on in vivo toxicity of AgNPs have been reported for various living organisms, such as zebrafish [ 33 , 34 ], catfish [ 35 ], common carp [ 36 ], Corbicula fluminea clam [ 37 ], Caenorhabditis elegans worm [ 38 ], and mice [ 39 , 40 ]. The interaction of metal nanoparticles with nucleic acids is also a hot topic in the field of bioinorganic research, due to the interest in elucidating possible effects of Ag nanoparticles on the synthesis, replication, and structural integrity of DNA and RNA [ 41 ] and the mechanism of DNA–nanoparticle binding [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Stabilized Ag Nanoparticles with Superior Biocompatibility and Their Synergistic Antibacterial Effect in Mixtures with Essential Oils

et al. 2018

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Silver nanoparticles (AgNPs) are considered a promising alternative to the use of antibiotics in fighting multidrug-resistant pathogens. However, their use in medical application is hindered by the public concern regarding the toxicity of metallic nanoparticles. In this study, rationally designed AgNP were produced, in order to balance the antibacterial activity and toxicity. A facile, environmentally friendly synthesis was used for the electrochemical fabrication of AgNPs. Chitosan was employed as the capping agent, both for the stabilization and to improve the biocompatibility. Size, morphology, composition, capping layer, and stability of the synthesized nanoparticles were characterized. The in vitro biocompatibility and antimicrobial activities of AgNPs against common Gram-negative and Gram-positive bacteria were evaluated. The results revealed that chitosan-stabilized AgNPs were nontoxic to normal fibroblasts, even at high concentrations, compared to bare nanoparticles, while significant antibacterial activity was recorded. The silver colloidal dispersion was further mixed with essential oils (EO) to increase the biological activity. Synergistic effects at some AgNP–EO ratios were observed, as demonstrated by the fractionary inhibitory concentration values. Our results reveal that the synergistic action of both polymer-stabilized AgNPs and essential oils could provide a significant efficiency against a large variety of microorganisms, with minimal side effects.

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Section: Introductionmentioning

confidence: 99%

Chitosan-Stabilized Ag Nanoparticles with Superior Biocompatibility and Their Synergistic Antibacterial Effect in Mixtures with Essential Oils

et al. 2018

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“…In comparison, our results revealed the lowest mortality at the highest concentration of B-AgNPs. A study conducted by [27] revealed the mortality in every concentration even by the lowest concentration (0.01 mg/L) of AgNPs. Another conducted study exhibited that 7/21 sh died at 0.03 mg/L after 96 hours of exposure to AgNPs [2], but in our study, there was mortality at 0.03 mg/L till the end of the experiment.…”

Section: Discussionmentioning

confidence: 98%

Long-term Exposure of High Concentration Silver Nanoparticles Induced Toxicity, Fatality, Bioaccumulation, and Histological Alteration in Common Carp Fish (Cyprinus carpio)

Kakakhel

Sajjad

et al. 2020

Preprint

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BackgroundCurrently, nanotechnology and nanoparticles have been quickly emerged and have gained the attention of scientists due to its massive applications in environmental sectors. However, these environmental applications of silver nanoparticles potentially cause serious effects on terrestrial and aquatic organisms. In the current study, freshwater fish C. carpio were exposed to blood mediated AgNPs for toxicity, mortality, bioaccumulation, and histological alterations. Silver nanoparticles were fabricated using animal blood serum and their toxic effect was studied against common carp fish at different concentrations level (0.03, 0.06, and 0.09 mg/L).ResultsThe findings have revealed a little effect of blood induced silver nanoparticles (B-AgNPs) on fish behavior at the highest concentration (0.09 mg/L). However, bioaccumulation of B-AgNPs was reported in different organs of fish. Maximum bioaccumulation of B-AgNPs was reported in the liver, followed by intestine, gills, and muscles. Furthermore, the findings have showed that the B-AgNPs bioaccumulation led to histopathological alterations including damage structure of gills tissue and caused necrosis. It is summarized that histopathological alteration in gills and intestine mostly occurred at the highest concentration of B-AgNPs (0.09 mg/L). ConclusionThis study provides evidence of the AgNPs influence on aquatic life; however, further systematic studies are crucial to access the effects of AgNPs on aquatic life.

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“…The previous studies stated the toxic effects of AgNPs can be mainly due to the release of silver ions (Khosravi‐Katuli, Shabani, Paknejad, & Imanpoor, 2018). Yue et al (2016) studied silver nanoparticle‐protein interactions in intact rainbow trout gill cells; they stated Ag + may cross the membrane through the ions channel such as Cu +2 transporters.…”

Section: Discussionmentioning

confidence: 99%

“…Yue et al (2016) studied silver nanoparticle‐protein interactions in intact rainbow trout gill cells; they stated Ag + may cross the membrane through the ions channel such as Cu +2 transporters. Silver ions crossed the cell membrane can lead to oxidative stress and death through inhibition of Na/K‐ATPase activity and induce the histopathological changes in the gills (Khosravi‐Katuli et al, 2018; Xiang et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

In vitro effects of silver nanoparticles on gills morphology of female Guppy (Poecilia reticulate) after a short‐term exposure

Mohsenpour

Mousavi‐Sabet

Hedayati

et al. 2020

Microscopy Res & Technique

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The application of nanoparticles in various industries has grown significantly in recent years. The aims of this study were evaluation effects of silver nanoparticles (AgNPs) on survival rate and tissues (Gills) of Guppy (Poecilia reticulate) as a model of the freshwater organism. For this purpose, 90 mature fish were exposed to a different level of AgNPs for 96 hr. Data analyzed showed there was a significant correlation between fish mortality rate and AgNPs concentrations. Histological assays showed some typical tissue damages such as hyperplasia, hypertrophy, hyperemia, hemorrhage, and necrosis. Moreover, fish exposed to a lethal concentration of AgNPs showed some clinical signs, such as increasing operculum movement, swimming near the water surface, anxiety, and death with open mouth. The results of the present study showed that AgNPs can have toxicity effects on Guppy, also to sub-lethal concentrations, leading to several tissue damages and reduced survival rate of fish.

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Comparative toxicity of silver nanoparticle and ionic silver in juvenile common carp (Cyprinus carpio): Accumulation, physiology and histopathology

Cited by 69 publications

References 41 publications

Chitosan-Stabilized Ag Nanoparticles with Superior Biocompatibility and Their Synergistic Antibacterial Effect in Mixtures with Essential Oils

Chitosan-Stabilized Ag Nanoparticles with Superior Biocompatibility and Their Synergistic Antibacterial Effect in Mixtures with Essential Oils

Long-term Exposure of High Concentration Silver Nanoparticles Induced Toxicity, Fatality, Bioaccumulation, and Histological Alteration in Common Carp Fish (Cyprinus carpio)

In vitro effects of silver nanoparticles on gills morphology of female Guppy (Poecilia reticulate) after a short‐term exposure

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