Comparative Toxicological Aspects of Complexes of Dibutyltin(IV) and DicycIopentadienyltitanium(IV) Derived from Oxygen Donor Ligands

Synthesis and biological applications of ionic triphenyltin(iv) chloride carboxylate complexes with exceptionally high cytotoxicity

“…The carboxylic acids used in this study (Fig. 1) have been previously used in the synthesis of different neutral triorganotin(IV) carboxylates, [44][45][46][47][48][49][50][51][52] however, the synthesis and characterization of more convenient ionic tin(IV) complexes containing these ligands have not yet been reported and their cytotoxicity has not been studied. Thus, as numerous reports show that there is not a single or a well-defined number of pathways for the interaction of tin compounds with the membrane or constituents within the cell [53][54][55][56] and many other studies indicate the possible mechanisms of action of tin compounds, the study of the biological properties and anticancer mechanisms of this new group of anionic organotin carboxylates, which may give rise to intermolecular interactions with an effect on the overall and the local tin environment and in the final cytotoxicity, is very useful for gaining novel insights on the cellular action of organotin complexes.…”