Comparative Toxicology of Inhaled 239PuO2 in Dogs and Rats

Abstract

only-Inhaled plutonium is a potent carcinogen in both dogs and rats. Young adult beagle dogs and Wistar rats, in lifespan studies designed to examine the relationship between dose and lungtumor incidence, were given a single exposure to high-fired 239Pu02 (AMAD values, 2.3 pm and 1.6 pm, respectively).Dosimetry and histopathology have been completed on 122 of 136 dogs and on 1436 of 3192 rats, including most animals with lung doses >