Comparative transcriptional profiling of regenerating damaged knee joints in two animal models of the newt Notophthalmus viridescens strengthens the role of candidate genes involved in osteoarthritis

Geyer, Matthias; Schönfeld, C.; Schreiyäck, C.; Susanto, S.A.; Michel, Christian; Looso, Mario; Braun, Thomas; Borchardt, Thilo; Neumann, Elena; Müller‐Ladner, Ulf

doi:10.1016/j.ocarto.2022.100273

Cited by 1 publication

(2 citation statements)

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“…Recently published evidence [198] shows that FGF signaling serves as an inducer of collagen regeneration and the formation of collagen fibrils during skin wound healing in axolotls. Information was also presented on the regeneration of knee cartilage in newts [199]. This model also provides a view of the ECM-dependent mechanisms of cartilage repair in tail regeneration.…”

Section: Molecular Regulators Of Tail Regeneration In Salamanders 41 ...mentioning

confidence: 99%

“…This model also provides a view of the ECM-dependent mechanisms of cartilage repair in tail regeneration. After applying damage of two types (surgical removal and collagenase treatment), the authors [199] identified molecular regulators of cartilage repair. To identify relevant candidate genes and determine their impact on regeneration, they used cDNA microarray analysis, real-time quantitative PCR, immunohistochemistry, and functional assays, which made it possible to identify groups of up-regulated genes in the cartilage regeneration process.…”

Section: Molecular Regulators Of Tail Regeneration In Salamanders 41 ...mentioning

confidence: 99%

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Tail and Spinal Cord Regeneration in Urodelean Amphibians

Grigoryan,

Markitantova

2024

Life

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Urodelean amphibians can regenerate the tail and the spinal cord (SC) and maintain this ability throughout their life. This clearly distinguishes these animals from mammals. The phenomenon of tail and SC regeneration is based on the capability of cells involved in regeneration to dedifferentiate, enter the cell cycle, and change their (or return to the pre-existing) phenotype during de novo organ formation. The second critical aspect of the successful tail and SC regeneration is the mutual molecular regulation by tissues, of which the SC and the apical wound epidermis are the leaders. Molecular regulatory systems include signaling pathways components, inflammatory factors, ECM molecules, ROS, hormones, neurotransmitters, HSPs, transcriptional and epigenetic factors, etc. The control, carried out by regulatory networks on the feedback principle, recruits the mechanisms used in embryogenesis and accompanies all stages of organ regeneration, from the moment of damage to the completion of morphogenesis and patterning of all its structures. The late regeneration stages and the effects of external factors on them have been poorly studied. A new model for addressing this issue is herein proposed. The data summarized in the review contribute to understanding a wide range of fundamentally important issues in the regenerative biology of tissues and organs in vertebrates including humans.

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Section: Molecular Regulators Of Tail Regeneration In Salamanders 41 ...mentioning

confidence: 99%

Section: Molecular Regulators Of Tail Regeneration In Salamanders 41 ...mentioning

confidence: 99%