Comparative transcriptome and metabolite profiling of four tissues from Alisma orientale (Sam.) Juzep reveals its inflorescence developmental and medicinal characteristics

Lin, Wenjin; Sun, Fengling; Zhang, Yamin; Xu, Xinlan; Lu, Xuehua; Li, Lisha; Xu, Ruihua

doi:10.1038/s41598-019-48806-w

Cited by 8 publications

(9 citation statements)

References 59 publications

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“…In terms of morphology, AR displaying a large overall size (~2–7 × 2–6 cm), yellow-white color, solid texture, and high powder content, are of high quality [ 33 ]. AR predominantly contain a suite of putatively bioactive terpenes, specifically protostane-type triterpenes and guaiane-type sesquiterpenes [ 34 ]. The triterpenoid components, including alisol B23-acetate, alisol B, and alisol C23-acetate, serve as the primary pharmacologically active compounds in AR [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

Properties and Fungal Communities of Different Soils for Growth of the Medicinal Asian Water Plantain, Alisma orientale, in Fujian, China

Xu,

Lin,

Keyhani

et al. 2024

JoF

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The Asian water plantain, Alisma orientale (Sam.) Juzep, is a traditional Chinese medicinal plant. The dried tubers of the Alisma orientale, commonly referred to as Alismatis rhizome (AR), have long been used in traditional Chinese medicine to treat a variety of diseases. Soil properties and the soil microbial composition are known to affect the quality and bioactivity of plants. Here, we sought to identify variations in soil fungal communities and soil properties to determine which would be optimal for cultivation of A. orietale. Soil properties, heavy metal content, and pesticide residues were determined from soils derived from four different agricultural regions around Shaowu City, Fujian, China, that had previously been cultivated with various crops, namely, Shui Dao Tu (SDT, rice), Guo Shu Tu (GST, pecan), Cha Shu Tu (CST, tea trees), and Sang Shen Tu (SST, mulberry). As fungi can either positively or negatively impact plant growth, the fungal communities in the different soils were characterized using long-read PacBio sequencing. Finally, we examined the quality of A. orientale grown in the different soils. Our results show that fungal community diversity of the GST soil was the highest with saprotrophs the main functional modes in these and SDT soils. Our data show that GST and SDT soils were most suitable for A. orientale growth, with the quality of the AR tubers harvested from GST soil being the highest. These data provide a systematic approach at soil properties of agricultural lands in need of replacement and/or rotating crops. Based on our findings, GST was identified as the optimal soil for planting A. orientale, providing a new resource for local farmers.

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Section: Resultsmentioning

confidence: 99%

Properties and Fungal Communities of Different Soils for Growth of the Medicinal Asian Water Plantain, Alisma orientale, in Fujian, China

Xu,

Lin,

Keyhani

et al. 2024

JoF

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“…They can serve as control markers to evaluate the quality of Zexie phyto-prepaprations of the Chinese Pharmacopoeia [ 75 , 137 ]. Ali-B and Ali-B 23-acetate are abundant in the plant roots, but also in the leaves, scapes, and inflorescences [ 138 ]. Ali-A is one of the quality markers which can be used to assess the quality of the TCM prescription Qiliqiangxin capsule (QLQX), used to treat chronic heart failure [ 18 ], whereas Ali-B 23-acetate is a quality marker for the Hugan Qingzhi formula used to treat nonalcoholic fatty liver disease [ 12 ].…”

Section: Discussion and Perspectivesmentioning

confidence: 99%

Pharmacological Properties and Molecular Targets of Alisol Triterpenoids from Alismatis Rhizoma

Bailly

2022

Biomedicines

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More than 100 protostane triterpenoids have been isolated from the dried rhizomes of Alisma species, designated Alismatis rhizoma (AR), commonly used in Asian traditional medicine to treat inflammatory and vascular diseases. The main products are the alisols, with the lead compounds alisol-A/-B and their acetate derivatives being the most abundant products in the plant and the best-known bioactive products. The pharmacological effects of Ali-A, Ali-A 24-acetate, Ali-B, Ali-B 23-acetate, and derivatives have been analyzed to provide an overview of the medicinal properties, signaling pathways, and molecular targets at the origin of those activities. Diverse protein targets have been proposed for these natural products, including the farnesoid X receptor, soluble epoxide hydrolase, and other enzymes (AMPK, HCE-2) and functional proteins (YAP, LXR) at the origin of the anti-atherosclerosis, anti-inflammatory, antioxidant, anti-fibrotic, and anti-proliferative activities. Activities were classified in two groups. The lipid-lowering and anti-atherosclerosis effects benefit from robust in vitro and in vivo data (group 1). The anticancer effects of alisols have been largely reported, but, essentially, studies using tumor cell lines and solid in vivo data are lacking (group 2). The survey shed light on the pharmacological properties of alisol triterpenoids frequently found in traditional phytomedicines.

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“…were selected as reference substances. Quantitative analysis of eight triterpenoids was performed on the Waters TQ TQS system of ultra high-performance liquid chromatography configured with a triple quadruple mass spectrometer (UPLC-QQQ-MS, Waters, UK), according to the methods used in previous research [36].…”

Section: Determination Of the Contents Of Triterpenoids In A Orientalementioning

confidence: 99%

Hypolipidemic effect of Alisma orientale (Sam.) Juzep on gut microecology and liver transcriptome in diabetic rats

Zhang

et al. 2020

PLoS ONE

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Alisma orientale (Sam.) Juzep (A. orientale) is a traditional herb that is often used to treat disease including edema and hyperlipidemia. However, the molecular mechanism by which Alisma orientale (Sam.) Juzep exerts its hypolipidemic effects remains unclear. In this study, a diabetic rat model was established by feeding a high-fat and high-sugar diet combined with a low-dose streptozotocin injection (HFS). Then the rats were treated with an A. orientale water extract (AOW), an A. orientale ethanolic extract (AOE) or metform (MET). The gut microflora and liver transcriptome were analyzed by high-throughput nextgeneration sequencing. Ultra-performance liquid chromatography-triple quadrupole-mass spectrometry was employed to analyze the major compounds in the AOE. The results showed that the serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels in rats of the AOE group (2.10 g/kg/day, 14 days) were significantly lower than those in the HFS group (p<0.01). Moreover, AOE treatment altered the gut microecology, particularly modulating the relative abundance of gut microflora involved in lipid metabolism compared with the HFS group. Furthermore, compared with the HFS group, the mRNA expression levels of Fam13a,

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Comparative transcriptome and metabolite profiling of four tissues from Alisma orientale (Sam.) Juzep reveals its inflorescence developmental and medicinal characteristics

Cited by 8 publications

References 59 publications

Properties and Fungal Communities of Different Soils for Growth of the Medicinal Asian Water Plantain, Alisma orientale, in Fujian, China

Properties and Fungal Communities of Different Soils for Growth of the Medicinal Asian Water Plantain, Alisma orientale, in Fujian, China

Pharmacological Properties and Molecular Targets of Alisol Triterpenoids from Alismatis Rhizoma

Hypolipidemic effect of Alisma orientale (Sam.) Juzep on gut microecology and liver transcriptome in diabetic rats

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