Comparative trial between two soft jelly capsules containing nonoxynol as spermicidal contraceptives

Assessment of a new modified soft jelly capsule containing nonoxynol as spermicide contraceptive

“…When the percentage of ruptured capsules was compared with that of our previous study (61%) [12], we found statistical differences (p < 0.05). In the present study, however, a slightly more hydrophobic vehicle was used, although the components of the capsule wall were not modified.…”

“…As in our previous study [12], vaginal infection, dryness and diminished muscle tone due to multiparity were observed in the subjects from groups II-V whose capsules did not rupture. However, these phenomena did not influence capsule rupture in groups VI-VIII.…”

“…In the present study, however, a slightly more hydrophobic vehicle was used, although the components of the capsule wall were not modified. This modification may account for the slight delay in the minimum time required for capsule rupture (3 minutes), compared with our last study (2.5 minutes) [12]. The mean time for capsule rupture was 8.2 minutes, less than the dissolution time required for conventional spermicides with an oil base widely used in Latin America [12].…”

“…Group I (n =5): study time 2 minutes Group II (n =5): study time 3 minutes Group III (n =5): study time 4 minutes Group IV (n = 5): study time 5 minutes Group V (n = 5): study time 7 minutes Group VI (n = 5): study time 9 minutes Group VII (n =5): study time 11 minutes Group VIII (n =5): study time 13 minutes These time intervals were selected according to our previous results [12].…”

“…Recently, we described a new spermicidal carrier (soft jelly capsule) containing nonoxynol-9 with some advantages over the conventional spermicides [12]. Several cases of spontaneous capsule rupture inside the package were reported in some cities in Mexico where humidity is high [13].…”