Comparative trial of Omnipaque 350 (iohexol) and Telebrix 350 (sodium-meglumine-ioxithalamate) in left ventriculography and coronary arteriography

Jorgova, J.; Sedney, M. I.; Wall, E. E. van der; Benthem, A. van; Buis, Beert

doi:10.1016/0720-048x(92)90210-z

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…Furthermore, ventricular angiography has the disadvantage that left ventricular ejection fraction may be overestimated because of stress to the patient, or underestimated because of the negative inotropic action of the contrast medium. 6 Several echocardiographic techniques can be applied to evaluate left ventricular systolic function. The fractional shortening and Teichholz techniques are not reliable when left ventricular contraction is asymmetrical.7-9 Cross sectional echocardiography tolerates asymmetry but requires good image quality for adequate tracing of the endocardial borders,'0-'2 which is not always obtainable.…”

mentioning

confidence: 99%

Left ventricular atrioventricular plane displacement: an echocardiographic technique for rapid assessment of prognosis in heart failure.

Willenheimer

Cline

Erhardt

et al. 1997

Heart

169

118

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Objective-To assess the prognostic value of atrioventricular plane displacement in heart failure patients. Design-Patients were followed prospectively for one year after atrioventricular plane displacement determination. Setting-Malmo University Hospital, with a primary catchment area of 250 000 inhabitants. Patients-181 patients with a clinical diagnosis of heart failure; age 75-7 (SD 5.2) years, duration of heart failure 2-7 (5.7) years; 100 men, 81 women. Main outcome measures-Mortality in relation to atrioventricular plane displacement. Results-Total mortality was 22-7% (41/181), and was highly significantly (P = 0.001) related to atrioventricular plane displacement. Mortality within prospectively defined categories of displacement was: > 10-0 mm, 0% (0/19); 8*2 to 9 9 mm, 10*3% (3129); 6-4 to 8-1 mm, 19*4% (12/62); and < 6'4 mm, 36-6% (26/71). The groups were similar in age, sex, angiotensin converting enzyme inhibitor and P blocker treatment, and cause and duration of heart failure. Conclusions-Mortality in heart failure is strongly related to atrioventricular plane displacement. (Heart 1997;78:230-236 The left ventricular pump function has traditionally been attributed mainly to the circumferentially orientated myocardial fibres.'9 However, the complexity of myocardial fibre orientation and the importance of longitudinal myocardial fibres was described in man in the early 1980s.20 The significance of longitudinal fibres for left ventricular ejection has since been further emphasised.21-29 The epicardial surface of the heart remains practically immobile during the cardiac cycle,22 and normal left ventricular ejection cannot take place unless the atrioventricular plane moves. During cardiac systole the atrioventricular plane moves towards the apex as a result of contraction of longitudinal fibres,22 and during diastole it moves away from the apex. Since the distance between the apex of the heart and the chest surface is constant during the cardiac cycle,212230 the atrioventricular plane displacement measured from the surface of the thorax, using transthoracic two dimensionally guided M mode echocardiography (fig 1), equals the intraventricular displacement.25 Left ventricular atrioventricular plane displacement determined in this way has been shown to correlate well with left ventricular ejection fraction calculated by cross sectional echocardiography using the area-length method (r = 0-96), left ventricular wall motion index (r = 091), radionuclide ventriculography (r = 0-82 to 087), and contrast cineangiography (r = 089).2629 Atrioventricular plane displacement reflects global left ventricular function despite left ventricular asymmetry, since it is determined in four different regions of the left ventricle-the septal, lateral, posterior, and 230 on 10 May 2018 by guest. Protected by copyright.

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mentioning

confidence: 99%

Left ventricular atrioventricular plane displacement: an echocardiographic technique for rapid assessment of prognosis in heart failure.

Willenheimer

Cline

Erhardt

et al. 1997

Heart

169

118

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“…Thus, in the present study we tested the potential of NAC to prevent or minimize the nephrotoxic effects of contrast agents in intact rats as well as in 5/6-nephrectomized (5/6-Nx) rats -a model of chronic renal insufficiency [29,30] . Since the differences in production of adverse effects between administration of the standard high-osmolar ionic monomer sodium-meglumine-ioxi thalamate contrast medium (Telebrix) and the low-osmolar non-ionic contrast medium iohexol (Omnipaque) are still controversial in clinical practice [17,[31][32][33] , we evaluated whether any differences in the development of CIN can be revealed when either Telebrix or Omnipaque were employed.…”

Section: Introductionmentioning

confidence: 99%

N-Acetylcysteine Attenuates Iodine Contrast Agent-Induced Nephropathy in 5/6-Nephrectomized Rats

Šochman¹,

Peregrin

Bürgelová³

et al. 2010

Kidney Blood Press Res

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Aims: In the present study we tested the efficacy of N-acetylcysteine (NAC) to minimize nephrotoxic effects of iodine contrast agents in intact rats as well as in 5/6-nephrectomized (5/6-Nx) rats. Methods: Rats were allocated to a group of intact rats (n = 42) and a group of 5/6-Nx rats (n = 42). After 1 month of recovery from surgery, 5/6-Nx rats and intact (sham-operated) animals received either 6 ml/kg body weight (b.w.) meglumine ioxithalamate (Telebrix 350) or 6 ml/kg b.w. iohexol (Omnipaque 350) intravenously with or without pretreatment with 100 mg/kg b.w. NAC. Plasma and urinary concentrations of creatinine, sodium and protein in 24-hour urine collections were determined prior to and on days 1, 3 and 7 after drug administration. Results: In intact animals, contrast agents caused no significant changes in kidney function throughout the duration of the experiment. In contrast, significant increases in plasma creatinine levels and decreases in creatinine clearance were induced by both contrast agents in 5/6-Nx rats. These changes were significantly attenuated by NAC pretreatment. Conclusion: The results of the present study demonstrate that iodine contrast agent-induced nephropathy in 5/6-Nx rats is significantly attenuated by intravenous pretreatment with NAC.

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Comparative trial of Omnipaque 350 (iohexol) and Telebrix 350 (sodium-meglumine-ioxithalamate) in left ventriculography and coronary arteriography

Cited by 2 publications

References 30 publications

Left ventricular atrioventricular plane displacement: an echocardiographic technique for rapid assessment of prognosis in heart failure.

Left ventricular atrioventricular plane displacement: an echocardiographic technique for rapid assessment of prognosis in heart failure.

N-Acetylcysteine Attenuates Iodine Contrast Agent-Induced Nephropathy in 5/6-Nephrectomized Rats

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