Comparative urinary excretion of ethoxyacetic acid in man and rat after single low doses of ethylene glycol monoethyl ether

Groeseneken, D; Veulemans, Hendrik; Masschelein, Raphaël; Vlem, E Van

doi:10.1016/0378-4274(88)90008-2

Cited by 30 publications

(29 citation statements)

References 16 publications

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“…One is the collection time of the urine samples. The activity of ALDH towards aldehydes is high, and in fact, the half life of EGEE was determined as only several hours in rats 16) . Thus the pooled urine of 24 h may have diminished the differences, if any, in EAA excretion rate.…”

mentioning

confidence: 97%

Reproductive Toxicity of Ethylene Glycol Monoethyl Ether in Aldh2 Knockout Mice

et al. 2007

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Ethylene glycol monoethyl ether (EGEE) can cause damage to testes and sperm, and its metabolites are believed to play an important role in its toxicity. Aldehyde dehydrogenase 2 (ALDH2) is involved in the metabolism of this chemical. To investigate whether and how the enzyme affects the toxicity of EGEE, we conducted experiments comparing Aldh2 knockout mice with wild-type mice. Administration of EGEE at 100 and 600 mg/kg/day for one week did not induce any significant change in the weight and body weight ratios of testes, prostate and epididymides in either Aldh2 knockout or wild-type mice. However, motion of sperm from the spermaduct, as analyzed with a Hamilton-Thorne Sperm analyzer, was slightly decreased in the low dose group, and significantly lower in the high dose group; and the percentage of progressive sperm was also reduced in the two EGEE groups. This effect of EGEE treatment was observed in the wild-type, but not in the Aldh2 knockout mice. Sperm motion from the cauda epididymides was not affected. On the other hand, the concentration of ethoxyacetic acid, a metabolite of EGEE, in 24 h pooled urine of EGEE-treated Aldh2 knockout mice was not significantly lower than that of the wild-type mice on most days of urine sampling. These results suggest that inactivation of the ALDH2 enzyme due to gene mutation may be linked to differences in the susceptibility to EGEE-induced sperm toxicity.

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confidence: 97%

Reproductive Toxicity of Ethylene Glycol Monoethyl Ether in Aldh2 Knockout Mice

et al. 2007

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“…19 It has been estimated that the half lives of EGBE metabolites are about 6 to 9 hours, 20 and the half lives of EGEE metabolites are about 48 hours. 21 There are few studies of the half life of PGME or PGMEA, but in one study, the mean excretion half life of PGME was about 4.4 hours. 22 The ACGIH has adopted a biological exposure index (BEI) for EGEE of 100 mg/g creatinine.…”

Section: Biological Monitoringmentioning

confidence: 97%

HETA 94-0191-2670, Bureau of Engraving, Incorporated, Minneapolis, Minnesota.

1997

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“…Es wurden keinerlei Hinweise auf die Bildung von 2-Ethoxyessigsäure-Konjugaten, z.B. eines Glycinkonjugates, gefunden (Groeseneken et al 1988). Basierend auf den Daten von Groeseneken et al (1986a, b) und den Beobachtungen von Veulemans et al (1987), daß es bei einer Exposition gegenüber 2-Ethoxyethanol am Arbeitsplatz über die Arbeitswoche zu einer Kumulation der 2-Ethoxyessigsäure im Harn kommt (siehe unten), wurden die resultierenden 2-Ethoxyessigsäure-Konzentrationen im Harn abgeschätzt: Bei einer rein inhalativen Exposition am Arbeitsplatz (8 Stunden/Tag) gegenüber 2-Ethoxyethanol-Konzentrationen in Höhe des bisherigen MAK-Wertes von 20 ml/m 3 (75 mg/m 3 ) ist am Ende der Arbeitswoche,je nach der Höhe der körperlichen Belastung, mit 2-Ethoxyessigsäure-Konzentrationen im Harn zwischen 40 und 140 mg/l zu rechnen (Henschler und Lehnert 1993).…”

Section: Toxikokinetik Experimentelle Expositionunclassified

“…Die Autoren korrigierten später die Halbwertszeit auf ca. 42 Stunden (Groeseneken et al 1988). Nach wiederholter Exposition über 5 Tage/Woche gegenüber 5 ml 2-Ethoxyethanol bzw.…”

Section: Exposition Am Arbeitsplatzunclassified

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2‐Ethoxyethanol, 2‐Ethoxyethylacetat [MAK Value Documentation in German language, 1994]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 20. Lieferung, Ausgabe 1994 Der Artikel enthält folgende Kapitel: Toxikokinetik Experimentelle Exposition Exposition am Arbeitsplatz In‐vitro‐Untersuchungen Erfahrungen beim Menschen Reproduktionstoxizität Tierexperimentelle Befunde Reproduktionstoxizität Bewertung

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Comparative urinary excretion of ethoxyacetic acid in man and rat after single low doses of ethylene glycol monoethyl ether

Cited by 30 publications

References 16 publications

Reproductive Toxicity of Ethylene Glycol Monoethyl Ether in Aldh2 Knockout Mice

Reproductive Toxicity of Ethylene Glycol Monoethyl Ether in Aldh2 Knockout Mice

HETA 94-0191-2670, Bureau of Engraving, Incorporated, Minneapolis, Minnesota.

2‐Ethoxyethanol, 2‐Ethoxyethylacetat [MAK Value Documentation in German language, 1994]

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