Comparative Usefulness of Beat-to-Beat QT Dispersion and QT Interval Fluctuations for Identifying Patients With Organic Heart Disease at Risk for Ventricular Arrhythmias.

Galeano, Erdulfo J.; Yoshida, Akihiro; Ohnishi, Yozo; Okajima, Katsunori; Ishida, Akihiko; Kitamura, Hidetsuna; Kubo, Shinya; Yokoyama, Mitsuhiro

doi:10.1253/circj.67.125

Cited by 11 publications

(4 citation statements)

References 20 publications

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“…Knowledge of this variability and its relationship to the SA may be a useful tool in assessing the drug effects on the cardiac function of laboratory dogs. Increase in QT variability over time, the so-called temporal QT dispersion induced by a drug, may be an indicator of its potential to produce ventricular arrhythmias and/or torsades de pointes (Galeano et al 2003). The variability of the PQ interval was found to be sensitive to the changes in autonomic tone (Hamlin 1972).…”

Section: Discussionmentioning

confidence: 99%

The electrocardiogram of the Beagle dog: reference values and effect of sex, genetic strain, body position and heart rate

Hanton

Rabémampianina

2006

Lab Anim

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SummaryThe aim of the study was to establish a database for electrocardiographic parameters of Beagle dogs used for toxicological studies and to evaluate the influence of supplier, sex, heart rate (HR) and body position for electrocardiogram (ECG) recording on ECG parameters. Peripheral ECG leads were recorded from 934 female and 946 male dogs from Marshall Farms and 27 females and 30 males from Harlan, either standing on a table or restrained in a hammock. HR, RR, PQ and QT intervals, P and QRS duration and P-wave amplitude were measured. There were no major differences between sexes for ECG parameters. The axis of the heart was shifted to the left when the animals were restrained in a hammock compared to when they were standing on a table. The PQ interval was higher (about 9%) in Harlan than in Marshall dogs. HR was negatively correlated with QT (coefficient of linear correlation: r ¼ À0.61 to À0.74), which emphasizes the need for a formula correcting QT interval for HR when interpreting changes in QT interval. HR was also negatively correlated with PQ intervals (r ¼ À0.26 to À0.11), whereas a positive correlation was found between HR and the amplitude of the P wave (r ¼ 0.21-0.34). The level of the respiratory sinus arrhythmia (SA) was quantified by calculating the ratio of maximum to minimum RR interval measured over a 10 s period. This ratio was negatively correlated with HR (r ¼ À0.49 to À0.33). Therefore, at high HRs, SA was less marked than at low HRs, but it did not completely disappear. Analysis of beat-to-beat variation indicated that QT and PQ intervals and the amplitude of P wave fluctuated over time and the degree of this variability was positively correlated with the level of SA. In conclusion, we have established reference values for the duration and/or amplitude of some ECG parameters both in terms of means and variability over the recording period, and we have evaluated the influence of body position, genetic strain and HR on the ECG parameters. These data can be used as baseline for the interpretation of the ECG of Beagle dogs.Keywords Dog; electrocardiogram (ECG); heart rate; QT interval; sinus arrhythmia Electrocardiogram (ECG) is a key examination when evaluating the effects of drugs on the cardiovascular system, and is performed routinely in toxicity and pharmacology studies. It provides critical information on a number of changes in the electrophysiological function, in particular the effects of a test compound on cardiac rhythmicity, conduction, depolarization and repolarization, which cannot be assessed by other methods and which have no morphological correlates visible at

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Section: Discussionmentioning

confidence: 99%

The electrocardiogram of the Beagle dog: reference values and effect of sex, genetic strain, body position and heart rate

Hanton

Rabémampianina

2006

Lab Anim

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“…Many studies have used QTd to stratify heart disease patients with respect to the presence of life-threatening arrhythmias and/or sudden death; [2][3][4][5][6] however, it fails to identify high-risk patients, mainly because the measure of QTd has essential methodological limitations. 7,8 The poor reproducibility of QT measurements indicates that there is an overlap of QTd values between healthy individuals and patients with heart disease.…”

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confidence: 99%

Clinical Implication of T-Wave Morphology Analysis as a New Repolarization Descriptor

Ono

Saitoh

Yan

et al. 2005

Circ J

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“…The beat‐to‐beat repolarization lability is associated with an increased risk for ventricular arrhythmias with organic heart disease 9,15 . Berger et al 8 reported that dilated cardiomyopathy is associated with increased beat‐to‐beat fluctuations in the QT interval as compared with normal hearts and that the increase causes a temporal lability in the ventricular repolarization.…”

Section: Discussionmentioning

confidence: 99%

Sodium Channel Blockers Enhance the Temporal QT Interval Variability in the Right Precordial Leads in Brugada Syndrome

Kanemori¹,

Shimizu²,

Oka³

et al. 2008

Noninvasive Electrocardiol

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Comparative Usefulness of Beat-to-Beat QT Dispersion and QT Interval Fluctuations for Identifying Patients With Organic Heart Disease at Risk for Ventricular Arrhythmias.

Cited by 11 publications

References 20 publications

The electrocardiogram of the Beagle dog: reference values and effect of sex, genetic strain, body position and heart rate

The electrocardiogram of the Beagle dog: reference values and effect of sex, genetic strain, body position and heart rate

Clinical Implication of T-Wave Morphology Analysis as a New Repolarization Descriptor

Sodium Channel Blockers Enhance the Temporal QT Interval Variability in the Right Precordial Leads in Brugada Syndrome

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