Comparative utility of MRI and EEG for early detection of cortical dysmaturation after postnatal systemic inflammation in the neonatal rat

White, Petra; Ranasinghe, Sumudu; Chen, Joseph; Van de Looij, Yohan; Sizonenko, Stéphane; Prasad, Jaya; Berry, Mary; Bennet, Laura; Gunn, Alistair; Dean, Justin

doi:10.1016/j.bbi.2024.07.028

Brain, Behavior, and Immunity

2024

DOI: 10.1016/j.bbi.2024.07.028

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Comparative utility of MRI and EEG for early detection of cortical dysmaturation after postnatal systemic inflammation in the neonatal rat

Petra White,

Sumudu Ranasinghe,

Joseph Chen

et al.

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Cited by 2 publications

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Detecting the early warning signs of neonatal brain injury

Liong

2025

Brain, Behavior, and Immunity

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Detecting the early warning signs of neonatal brain injury

Liong

2025

Brain, Behavior, and Immunity

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Chronic Inflammation Offers Hints About Viable Therapeutic Targets for Preeclampsia and Potentially Related Offspring Sequelae

Prasad,

Van Steenwinckel,

Gunn

et al. 2024

IJMS

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The combination of hypertension with systemic inflammation during pregnancy is a hallmark of preeclampsia, but both processes also convey dynamic information about its antecedents and correlates (e.g., fetal growth restriction) and potentially related offspring sequelae. Causal inferences are further complicated by the increasingly frequent overlap of preeclampsia, fetal growth restriction, and multiple indicators of acute and chronic inflammation, with decreased gestational length and its correlates (e.g., social vulnerability). This complexity prompted our group to summarize information from mechanistic studies, integrated with key clinical evidence, to discuss the possibility that sustained or intermittent systemic inflammation-related phenomena offer hints about viable therapeutic targets, not only for the prevention of preeclampsia, but also the neurobehavioral and other developmental deficits that appear to be overrepresented in surviving offspring. Importantly, we feel that carefully designed hypothesis-driven observational studies are necessary if we are to translate the mechanistic evidence into child health benefits, namely because multiple pregnancy disorders might contribute to heightened risks of neuroinflammation, arrested brain development, or dysconnectivity in survivors who exhibit developmental problems later in life.

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Comparative utility of MRI and EEG for early detection of cortical dysmaturation after postnatal systemic inflammation in the neonatal rat

Cited by 2 publications

References 102 publications

Detecting the early warning signs of neonatal brain injury

Detecting the early warning signs of neonatal brain injury

Chronic Inflammation Offers Hints About Viable Therapeutic Targets for Preeclampsia and Potentially Related Offspring Sequelae

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