Comparative vascular responses in elasmobranchs to different structures of neuropeptide Y and peptide YY

Preston, Elaine; Jönsson, Ann-Cathrine; McManus, C.; Conlon, J. Michael; Courtice, Gillian P.

doi:10.1016/s0167-0115(98)00116-5

Cited by 12 publications

(10 citation statements)

References 34 publications

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“…A potent vasoconstriction is induced in several vascular beds, such as the mesenteric arteries in pig, the celiac and mesenteric arteries in crocodile, and the dogfish afferent branchial arteries (4,19,28). Intravenous injection of dogfish, frog, and human NPY produced similar vasopressor effects in three elasmobranch species, except that human NPY lowered blood pressure in one (Portjackson shark) of the three species (33). In addition, NPY may have vasodilator effects (23,32,41,43).…”

mentioning

confidence: 99%

“…This peptide has several biological effects, including stimulation of food intake; hormone release; and cardiovascular functions, particularly vasoconstriction, reduction of coronary blood flow, and reduction of cardiac output (7,29). The regulation of cardiovascular functions by NPY appears to be common to most vertebrates, including elasmobranch fish (4,33). A potent vasoconstriction is induced in several vascular beds, such as the mesenteric arteries in pig, the celiac and mesenteric arteries in crocodile, and the dogfish afferent branchial arteries (4,19,28).…”

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confidence: 99%

“…The zYb and zYc genes show 76% identity and both show high homology to the cod Yb receptor gene (1). The receptor mediating blood pressure responses in elasmobranch species functionally is more like a Y 1 than a Y 2 receptor (33).…”

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confidence: 99%

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Neuropeptide Y effects on vasorelaxation and intestinal contraction in the Atlantic cod Gadus morhua

Shahbazi

Holmgren

Larhammar

et al. 2002

American Journal of Physiology-Regulatory, Integrative and Comp

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Neuropeptide Y (NPY) has prominent cardiovascular effects in mammals and sharks, but no such effect has previously been demonstrated in any teleost fish. In the Atlantic cod, we found that cod NPY (10(-10)-10(-6) M) relaxed celiac arteries precontracted with epinephrine, and weak contractions were elicited in intestinal ring preparations. A few NPY-immunoreactive nerve fibers were present along small gut arteries. The results suggest that cod NPY produces vasorelaxation both by a direct action on smooth muscle and by release of prostaglandins, but with no involvement of nitric oxide, leukotrienes, or endothelium-derived relaxing factors. An additional indirect effect involving another neurotransmitter may occur. Cod NPY (10(-7) M) and human NPY (10(-7) M) had identical effects on the vessels. Small differences only in the effects of porcine [Leu(31),Pro(34)]NPY, NPY-(13-36), and cod NPY suggest the presence of a Y(1) subfamily receptor, similar to the zebrafish Ya receptor. A physiological role for NPY in teleost vasculature is concluded, but surprisingly the effect, a vasodilation, is opposite to that in mammals and is mediated by prostaglandins.

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confidence: 99%

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confidence: 99%

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Neuropeptide Y effects on vasorelaxation and intestinal contraction in the Atlantic cod Gadus morhua

Shahbazi

Holmgren

Larhammar

et al. 2002

American Journal of Physiology-Regulatory, Integrative and Comp

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“…In contrast, cod NPY causes vasodilation in the cod celiac artery (Shahbazi et al, 2002). In the elasmobranchs, the unanesthetized Scyliorinus canicula (Conlon et al, 1991) and the anesthetized Heterodontus portjacksoni (Preston et al, 1998), IA or intravenous injection of relatively high doses of dogfish NPY or PYY significantly increase blood pressure. However in trout, IA injection of trout NPY and PYY at a 100 pmol dose is devoid of significant cardiovascular effects (unpublished data).…”

Section: Effects Of Intracerebroventricular Injections Of Neuropeptidesmentioning

confidence: 99%

Brain neuropeptides in central ventilatory and cardiovascular regulation in trout

et al. 2012

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Many neuropeptides and their G-protein coupled receptors (GPCRs) are present within the brain area involved in ventilatory and cardiovascular regulation but only a few mammalian studies have focused on the integrative physiological actions of neuropeptides on these vital cardio-respiratory regulations. Because both the central neuroanatomical substrates that govern motor ventilatory and cardiovascular output and the primary sequence of regulatory peptides and their receptors have been mostly conserved through evolution, we have developed a trout model to study the central action of native neuropeptides on cardio-ventilatory regulation. In the present review, we summarize the most recent results obtained using this non-mammalian model with a focus on PACAP, VIP, tachykinins, CRF, urotensin-1, CGRP, angiotensin-related peptides, urotensin-II, NPY, and PYY. We propose hypotheses regarding the physiological relevance of the results obtained.

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“…In dogfish hearts, NPY increases cardiac output by increasing heart rate and, in combination with norepinephrine, there was increased pressure [120]. Both NPY and PYY contracted isolated gut arteries in three species of elasmobranchs [121]. In eel, NPY enhanced the contractile force of the isolated atrium [122,123].…”

Section: Discussionmentioning

confidence: 99%

Evolutionary perspective on the NPY-PYY-PP peptides and their receptors

Larhammar

Salaneck

The NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis and Cancer

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Comparative vascular responses in elasmobranchs to different structures of neuropeptide Y and peptide YY

Cited by 12 publications

References 34 publications

Neuropeptide Y effects on vasorelaxation and intestinal contraction in the Atlantic cod Gadus morhua

Neuropeptide Y effects on vasorelaxation and intestinal contraction in the Atlantic cod Gadus morhua

Brain neuropeptides in central ventilatory and cardiovascular regulation in trout

Evolutionary perspective on the NPY-PYY-PP peptides and their receptors

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