Comparatively weak after-effects of transcranial alternating current stimulation (tACS) on cortical excitability in humans

Antal, Andrea; Boros, Klára; Poreisz, Csaba; Chaieb, Leila; Terney, Daniella; Paulus, Walter

doi:10.1016/j.brs.2007.10.001

Cited by 444 publications

(367 citation statements)

References 27 publications

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“…Different from tDCS, tACS has no major plasticity-inducing effect [22] , although recent studies suggest that exceptions do exist [23] . Modelling and animal and human studies have shown that relatively focal AC stimulation can lead to widespread entrainment of oscillatory activity at the induced frequency [24,25] .…”

Section: Physiology Of Transcranial Electrical Stimulationmentioning

confidence: 99%

Exploring prefrontal cortex functions in healthy humans by transcranial electrical stimulation

Kuo

Nitsche²

2015

Neurosci. Bull.

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The prefrontal cortex is involved in a multitude of cognitive, emotional, motivational, and social processes, so exploring its specifi c functions is crucial for understanding human experience and behavior. Functional imaging approaches have largely contributed to the enhancement of our understanding, but might have limitations in establishing causal relationships between physiology and the related psychological and behavioral processes. Non-invasive electrical stimulation with direct or alternating currents can help to enhance our understanding with regard to specific processes, and might provide future protocols able to improve them in case of malfunctions. We review the current state of the fi eld, and provide an outlook for future developments.

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Section: Physiology Of Transcranial Electrical Stimulationmentioning

confidence: 99%

Exploring prefrontal cortex functions in healthy humans by transcranial electrical stimulation

Kuo

Nitsche²

2015

Neurosci. Bull.

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“…• Note that the technique can also be applied when using other transcranial electric therapies such as tACS 29 or tRNS 30 .…”

Section: Discussionmentioning

confidence: 99%

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

DaSilva

Volz

Bikson

et al. 2011

JoVE

247

196

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Transcranial direct current stimulation (tDCS) is a technique that has been intensively investigated in the past decade as this method offers a non-invasive and safe alternative to change cortical excitability 2 . The effects of one session of tDCS can last for several minutes, and its effects depend on polarity of stimulation, such as that cathodal stimulation induces a decrease in cortical excitability, and anodal stimulation induces an increase in cortical excitability that may last beyond the duration of stimulation 6 . These effects have been explored in cognitive neuroscience and also clinically in a variety of neuropsychiatric disorders -especially when applied over several consecutive sessions 4 . One area that has been attracting attention of neuroscientists and clinicians is the use of tDCS for modulation of pain-related neural networks 3,5 . Modulation of two main cortical areas in pain research has been explored: primary motor cortex and dorsolateral prefrontal cortex 7 . Due to the critical role of electrode montage, in this article, we show different alternatives for electrode placement for tDCS clinical trials on pain; discussing advantages and disadvantages of each method of stimulation.

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“…Fourth, interhemispheric inhibition must be accounted for, especially in motor cortex stimulation, where any motor effect on one side of the body will be followed by the opposite effect on the other side of the body (Vines et al, 2006). Fifth, when experimenting with patient groups, medication must be carefully considered, because it has been shown that different substances may significantly alter the effects of tDCS (Kuo et al, 2007;Kuo et al, 2008;Nitsche et al, 2003;Nitsche et al, 2004;Terney et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…A single oral dose of L-DOPA blocked any tDCS-induced excitatory effects on MEPs after 13-min=1-mA anodal stimulation of the primary motor cortex and prolonged the tDCS induced inhibitory effects on MEPs (Kuo, Paulus, & Nitsche, 2008). Similarly, pergolide, another dopaminergic agonist, was shown to prolong the 15-min=1-mA cathodal tDCSinduced inhibitory aftereffects on laser-evoked potentials from 40 min to 24 hr (Terney et al, 2008). Hence, different dopaminergic agonists have shown opposite effects on tDCS, one prolonging the effects of anodal stimulation but not of cathodal stimulation and the other two blocking the effects of anodal stimulation and=or prolonging the effects of cathodal stimulation.…”

Section: Pharmacological Interactions With Tdcsmentioning

confidence: 99%

“…Effects of tDCS in humans include changes in behavioral measures, like in motor performance (Vines, Cerruti & Schlaug, 2008;Vines, Nair, & Schlaug, 2006) and cognitive performance 338 E. ANGELAKIS AND E. LIOUTA Floel, Rosser, Michka, Knecht, & Breitenstein, 2008;Fregni, Boggio, Nitsche, 2005;Iyer et al, 2005;Kincses, Antal, Nitsche, Bártfai, & Paulus, 2004;Monti et al, 2008), and in sensory perception (Antal, Nitsche, & Paulus, 2001); changes in electrophysiological measures, such as motor-evoked potentials (MEPs; Ardolino et al, 2005;Furubayashi et al, 2008;Nitsche & Paulus, 2000;Quartarone et al, 2004) or event-related potentials (Keeser et al, 2011;NakamuraPalacios et al, 2011), intramuscular coherence (Power et al, 2006), EEG visual-evoked potentials or pain-evoked potentials (Accornero, Li Voti, La Riccia, & Gregori, 2007;Antal, Brepohl, et al, 2008;Terney et al, 2008), and EEG amplitude (Ardolino et al, 2005;Marshall, Moelle, Hallschmid, & Born, 2004), as well as in brain hemodynamic changes measured by functional magnetic resonance imaging (Baudewig, Nitsche, Raulus, & Frahm, 2001;Kwon et al, 2008;Zheng, Alsop, & Schlaug, 2011), or by positron emission tomography (PET; Lang et al, 2005). Using functional magnetic resonance imaging, Baudewig and colleagues (2001) found decreased regional cerebral blood flow (rCBF) after 5 min of cathodal tDCS at the primary motor cortex, and no changes after anodal tDCS.…”

Section: Primary Effects Of Tdcsmentioning

confidence: 99%

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