As a rule, the innovation environment is considered within the boundaries of a specific region, taking into account the territorial aspect. This point of view is taken into consideration in Russian scientific publications and economic policy. The article deals with a comparative analysis of the category "region innovation environment" and "spatial innovation environment". The criterion for distinguishing between concepts is the spatial boundaries of this environment. Innovative environment of the region can be considered as real. The spatial innovation environment should be described as potentially possible, taking into account the mismatch of its borders with the boundaries of a particular region. As usual the innovation environment of the region goes beyond its administrative boundaries. In this case, the definition "spatial innovation environment" is methodologically justified. The exogenous nature of radical innovations in relation to a particular region is shown. The author's position is based on foreign researches, in which there is no rigid dependence of the region's economic development level on the development of the innovation environment of the region. The research shows that the quantitative parameters of the innovation environment development in the region do not always give an objective picture of the innovative development of a particular region. Indicators of innovative development make it possible to measure only the production of innovations in the region, but do not offer a mechanism for their dissemination and use. The study of the macro region innovation environment of the south of Western Siberia showed that there are conditions for competition for intellectual resources. The process of innovation can give a positive effect, taking into consideration the cooperation of relevant agglomerations innovative environment, excluding duplicate innovative projects. It is necessary to transform regional innovation spaces into a common interregional innovation cluster. Because of it the creation of a coordinating interregional body is necessary.