Comparing Alloimmunization in Preterm Infants After Transfusion of Fresh Unmodified Versus Stored Leukocyte-Reduced Red Blood Cells

Strauss, Ronald G.; Cordle, Delores G.; Quijana, Jacinta; Goeken, Nancy E.

doi:10.1097/00043426-199905000-00011

Cited by 31 publications

(39 citation statements)

References 24 publications

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“…The formation of red cell antibodies may be influenced by the patients' age at which the transfusions are given or when chronic transfusion therapy is started. Four studies on RBC alloimmunization performed in (pre-term) neonates who received multiple transfusions during the first 3-4 months of life did not encounter any RBC antibodies [202][203][204][205] 165,171,196,198,201 . The conflicting results are explained by the number of transfusions, the interval between transfusionsevents, the frequency of antibody testing (single versus serial) and the specificity of the antibodies (e.g.…”

Section: Red Blood Cell Antibodies In Diseasementioning

confidence: 95%

Red Blood Cell Alloimmunization after Blood Transfusion

Schonewille¹

2007

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Section: Red Blood Cell Antibodies In Diseasementioning

confidence: 95%

Red Blood Cell Alloimmunization after Blood Transfusion

Schonewille¹

2007

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“…Human studies have not noted an association between the duration of RBC storage and recipient alloimmune responses [42,43,44], although one recent study has shown a correlation between storage time and in vitro phagocytosis [45]. Potentially important considerations in the interpretation of these studies, however, include the definition of an ‘older' RBC unit as well as whether the recipients received fresh RBCs in combination with older RBCs.…”

Section: Donor- or Product-specific Factorsmentioning

confidence: 99%

Factors Influencing RBC Alloimmunization: Lessons Learned from Murine Models

Ryder

Zimring

Hendrickson

2014

Transfus Med Hemother

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Red blood cell (RBC) alloimmunization may occur following transfusion or pregnancy/delivery. Although observational human studies have described the immunogenicity of RBC antigens and the clinical significance of RBC alloantibodies, studies of factors influencing RBC alloimmunization in humans are inherently limited by the large number of independent variables involved. This manuscript reviews data generated in murine models that utilize transgenic donor mice, which express RBC-specific model or authentic human blood group antigens. Transfusion of RBCs from such donors into nontransgenic but otherwise genetically identical recipient mice allows for the investigation of individual donor or recipient-specific variables that may impact RBC alloimmunization. Potential donor-related variables include methods of blood product collection, processing and storage, donor-specific characteristics, RBC antigen-specific factors, and others. Potential recipient-related variables include genetic factors (MHC/HLA type and polymorphisms of immunoregulatory genes), immune activation status, phenotype of regulatory immune cell subsets, immune cell functional characteristics, prior antigen exposures, and others. Although murine models are not perfect surrogates for human biology, these models generate phenomenological and mechanistic hypotheses of RBC alloimmunization and lay the groundwork for follow-up human studies. Long-term goals include improving transfusion safety and minimizing the morbidity/mortality associated with RBC alloimmunization.

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“…AIDS patients may not form anti-D after D-mismatched transfusions at all, possibly attributable to their immunosuppressed state with CD4-positive T-cell deficiency [48]. Likewise, also preterm infants known to have an immature immune system are unlikely to form RBCA [56]. It can be suspected that also very old patients have a blunted immune response towards RBC antigens; however, part of such reduced alloimmunization tendency will be counterbalanced by a higher risk for secondary immunization based on anamnestic exposure throughout earlier decades of life.…”

Section: Clinical Factors Influencing Red Blood Cell Alloimmunizationmentioning

confidence: 99%

Responder Individuality in Red Blood Cell Alloimmunization

Körmöczi

Mayr²

2014

Transfus Med Hemother

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Many different factors influence the propensity of transfusion recipients and pregnant women to form red blood cell alloantibodies (RBCA). RBCA may cause hemolytic transfusion reactions, hemolytic disease of the fetus and newborn and may be a complication in transplantation medicine. Antigenic differences between responder and foreign erythrocytes may lead to such an immune answer, in part with suspected specific HLA class II associations. Biochemical and conformational characteristics of red blood cell (RBC) antigens, their dose (number of transfusions and pregnancies, absolute number of antigens per RBC) and the mode of exposure impact on RBCA rates. In addition, individual circumstances determine the risk to form RBCA. Responder individuality in terms of age, sex, severity of underlying disease, disease- or therapy-induced immunosuppression and inflammation are discussed with respect to influencing RBC alloimmunization. For particular high-risk patients, extended phenotype matching of transfusion and recipient efficiently decreases RBCA induction and associated clinical risks.

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Comparing Alloimmunization in Preterm Infants After Transfusion of Fresh Unmodified Versus Stored Leukocyte-Reduced Red Blood Cells

Cited by 31 publications

References 24 publications

Red Blood Cell Alloimmunization after Blood Transfusion

Red Blood Cell Alloimmunization after Blood Transfusion

Factors Influencing RBC Alloimmunization: Lessons Learned from Murine Models

Responder Individuality in Red Blood Cell Alloimmunization

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