Comparing anaesthetic effects of intrathecal 2- Chloroprocaine with or without fentanyl in ambulatory surgeries- A prospective and randomized control study

Abstract

Background: 1% 2-Chloroprocaine could have been an ideal local anaesthetic for ambulatory procedures but it has been neglected in past years and even after re introduction with its preservative and antioxidant free form. Aim: To compare the anaesthetic effect of intrathecal 2-Chloroprocaine with or without fentanyl in patients undergoing short duration lower abdominal and lower limb surgeries regarding hemodynamic parameters, mean duration of block, time to ambulation and side effects.

Comparison of 1% Chloroprocaine in Sub-Arachnoid Block With or Without Fentanyl for Enhanced Recovery After Perianal Surgeries

“…The literature suggests that the findings of prolongation of sensory block and post-operative analgesia are consistent with experimental as well as clinical synergistic interaction between spinal opioids and local anesthetics [9]. Our results are in concordance with the study done by Nagar et al in which the duration of analgesia and time to first analgesic dose was significantly prolonged in chloroprocaine with fentanyl group (p<0.001) [10]. Our findings are also similar to those obtained with the study conducted by Madhusudhana et al and Singariya et al in which the time to first demand of analgesia (duration of analgesia) was significantly longer in post-operative period in the chloroprocaine with fentanyl group [11,12].…”

“…No incidence of transient neurological symptoms was noted in our study. Although the concentration, volume of LA, and opioid intrathecally as used in our study were not similar to those used in various previous studies, but their results are similar to our findings [10][11][12].…”

“…Bhaskara et al and Suryanarayana et al have also shown similar results in their studies[13,14]. However, our findings are not consistent with the studies done by Nagar et al and Singariya et al[10,12] There is disparity regarding onset of sensory block which might be due to different techniques and ways of assessment of parameter and different doses of drugs used in these studies. Time taken to attain peak sensory block (T6) in our study was comparable in both groups, p=0.204.…”