Comparing calvarial transport distraction with and without radiation and fat grafting

Yuhasz, Mikell M.; Koch, Felix P.; Kwiatkowski, Anna; Young, Calvin J.; Clune, James; Travieso, Rob; Wong, Kenneth R.; Houten, Joshua Van; Steinbacher, Derek M.

doi:10.1016/j.jcms.2014.04.003

Cited by 5 publications

(3 citation statements)

References 46 publications

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“…In our study, the calvarial periosteum with higher VEGF content had vessels dispersed in the adipose layer. This structure may be closely related to bone formation in the case of the calvarial periosteum . On seeding HUVECs into two types of periosteum ECM scaffolds, DCP was found to show higher VEGF, HIF1-α, and Ang-I expression than DTP, indicating that it promoted angiogenesis.…”

Section: Discussionmentioning

confidence: 90%

“…This structure may be closely related to bone formation in the case of the calvarial periosteum. 38 On seeding HUVECs into two types of periosteum ECM scaffolds, DCP was found to show higher VEGF, HIF1-α, and Ang-I expression than DTP, indicating that it promoted angiogenesis. The HIF1-α and Ang-I can interplay with VEGF to regulate various cells (e.g., osteoblasts, endothelial cells, and fibroblasts) to enhance new vessel and bone formation.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Preparation and Evaluation of Tibia- and Calvarium-Derived Decellularized Periosteum Scaffolds

Zhang

Chen

et al. 2017

ACS Biomater. Sci. Eng.

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The periosteum plays a key role in bone regeneration and an artificial bionic material is urgently required. The periostea on the tibia and skull differ with respect to the types of cells, microstructure, and components, leading to different biological functions and biomechanical properties. We aimed to prepare decellularized periosteum scaffolds derived from different origins and evaluate their angiogenic and osteogenic activities. Histological assessment of α-smooth muscle actin, bone morphogenetic protein-2, and alkaline phosphatase in tibial and calvarial periosteum tissues provided preliminary information on their differing angiogenic and osteogenic properties. We developed decellularization protocols to completely remove the periosteum cellular components and for good maintenance of the hierarchical multilayer structures and components of the extracellular matrix (ECM) with no cytotoxicity. Moreover, using a chicken egg chorioallantoic membrane assay and a nude mouse implantation model, we found that tibia-derived periosteum ECM had superior osteogenic activity and calvarium-derived ECM had good angiogenic activity. The preliminary mechanisms of differing activities were then evaluated by osteogenesis- and angiogenesis-related gene expression in human umbilical vein endothelial cell- and MC-3T3 cell-seeded ECM scaffolds. Thus, this study provides periosteum biomaterials that are derived from specific tissues and have different functional properties and structures, for use in bone regeneration.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 97%

Preparation and Evaluation of Tibia- and Calvarium-Derived Decellularized Periosteum Scaffolds

Zhang

Chen

et al. 2017

ACS Biomater. Sci. Eng.

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“…Krebsbach explored the effect of BMP-7 gene therapy for skeletal regeneration in cranial defects compromised by postoperative radiotherapy and reported that BMP-7 ex vivo gene therapy was capable of successfully regenerating bone in rat calvarial defects even after therapeutic radiation (Nussenbaum et al , 2003). BMP-2 therapy delivered via an absorbable collagen sponge has also been shown to be effective in reconstructing calvarial defects in the unfavorable irradiated calvarial wound (Yuhasz et al , 2014) and the challenging infected unfavorable wound (Yuhasz et al , 2014) but not in a calvarial wound complicated by dural compromise (Yuhasz et al , 2014). Further studies are required to identify additional biomaterials, cell-, and GF therapy that can be translated to the clinic to address these challenging clinical dilemmas.…”

Section: Critical Clinical Challenges Of Craniofacial Bone Reconstructionmentioning

confidence: 99%

Biomaterials for Craniofacial Bone Engineering

et al. 2014

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Conditions such as congenital anomalies, cancers, and trauma can all result in devastating deficits of bone in the craniofacial skeleton. This can lead to significant alteration in function and appearance that may have significant implications for patients. In addition, large bone defects in this area can pose serious clinical dilemmas, which prove difficult to remedy, even with current gold standard surgical treatments. The craniofacial skeleton is complex and serves important functional demands. The necessity to develop new approaches for craniofacial reconstruction arises from the fact that traditional therapeutic modalities, such as autologous bone grafting, present myriad limitations and carry with them the potential for significant complications. While the optimal bone construct for tissue regeneration remains to be elucidated, much progress has been made in the past decade. Advances in tissue engineering have led to innovative scaffold design, complemented by progress in the understanding of stem cell-based therapy and growth factor enhancement of the healing cascade. This review focuses on the role of biomaterials for craniofacial bone engineering, highlighting key advances in scaffold design and development.

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Heritable Skeletal Disorders Arising from Defects in Processing and Transport of Type I Procollagen from the ER: Perspectives on Possible Therapeutic Approaches

Cutrona

Morgan

Simpson

2017

Targeting Trafficking in Drug Development

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Rare bone disorders are a heterogeneous group of diseases, initially associated with mutations in type I procollagen (PC) genes. Recent developments from dissection at the molecular and cellular level have expanded the list of disease-causing proteins, revealing that disruption of the machinery that handles protein secretion can lead to failure in PC secretion and in several cases result in skeletal dysplasia. In parallel, cell-based in vitro studies of PC trafficking pathways offer clues to the identification of new disease candidate genes. Together, this raises the prospect of heritable bone disorders as a paradigm for biosynthetic protein traffic-related diseases, and an avenue through which therapeutic strategies can be explored.Here, we focus on human syndromes linked to defects in type I PC secretion with respect to the landscape of biosynthetic and protein transport steps within the early secretory pathway. We provide a perspective on possible therapeutic interventions for associated heritable craniofacial and skeletal disorders, considering different orders of complexity, from the cellular level by manipulation of proteostasis pathways to higher levels involving cell-based therapies for bone repair and regeneration.

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Comparing calvarial transport distraction with and without radiation and fat grafting

Cited by 5 publications

References 46 publications

Preparation and Evaluation of Tibia- and Calvarium-Derived Decellularized Periosteum Scaffolds

Preparation and Evaluation of Tibia- and Calvarium-Derived Decellularized Periosteum Scaffolds

Biomaterials for Craniofacial Bone Engineering

Heritable Skeletal Disorders Arising from Defects in Processing and Transport of Type I Procollagen from the ER: Perspectives on Possible Therapeutic Approaches

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