Comparing clinical effects of photodynamic therapy as a novel method with topical corticosteroid for treatment of Oral Lichen Planus

Bakhtiari, Somayeh; Azari-Marhabi, Saranaz; Mojahedi, Seyyed Masoud; Namdari, Mahshid; Rankohi, Zahra Elmi; Jafari, Soudeh

doi:10.1016/j.pdpdt.2017.06.002

Cited by 59 publications

(148 citation statements)

References 21 publications

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“…Three studies included local steroid therapy as control group. In all studies, the follow‐up period ranged from 4 to 48 weeks (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…The risk of bias was considered high in 5 studies and moderate in one RCT assessed . None of the 2 RCTs estimated the sample size.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies compared clinical outcomes between steroid and PDT, in which 2 studies showed significantly higher improvements with steroid therapy compared to PDT, while one study showed comparable outcomes between PDT and steroid use.…”

Section: Resultsmentioning

confidence: 99%

“…A number of studies have reported the outcomes of PDT in the management of OLP and showed conflicting results . In a clinical study by Mostafa et al, OLP patients treated with topical steroid showed significant improvement in signs and symptoms as compared to those patients treated with PDT.…”

Section: Introductionmentioning

confidence: 99%

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Photodynamic therapy in the treatment of symptomatic oral lichen planus: A systematic review

Akram

Javed

Hosein

et al. 2017

Photoderm Photoimm Photomed

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Summary Background The aim of this systematic review was to assess the efficacy of photodynamic therapy (PDT) in the treatment of symptomatic oral lichen planus (OLP). Methods This systematic review aimed to address the following focused question: “Is PDT effective in the treatment of symptomatic OLP?” Indexed databases such as MEDLINE, EMBASE, and CENTRAL were searched up to and including August 2017. Results Six clinical studies were included. The risk of bias was considered high in 5 studies and moderate in one study. Parameters of PDT such as wavelengths, energy fluence, power density and exposure time ranged between 320‐660 nm, 120 J/cm2, 130 mW/cm2, and 70‐150 seconds, respectively. The follow‐up period ranged from 4 to 48 weeks. All included studies reporting clinical scores showed that PDT was effective in the treatment of OLP in adult patients at follow‐up. However, PDT did not show significant improvement when compared with steroid therapy. Conclusion Photodynamic therapy appears to have some effect in the symptomatic treatment of OLP in adult patients. However, further randomized controlled trials with long follow‐up period, standardized PDT parameters, and comparing the efficacy of PDT with steroid therapy are warranted to obtain strong conclusions in this regard.

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“…Three studies included local steroid therapy as control group. In all studies, the follow‐up period ranged from 4 to 48 weeks (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…The risk of bias was considered high in 5 studies and moderate in one RCT assessed . None of the 2 RCTs estimated the sample size.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Photodynamic therapy in the treatment of symptomatic oral lichen planus: A systematic review

Akram

Javed

Hosein

et al. 2017

Photoderm Photoimm Photomed

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“…Interestingly, despite any direct correlation of a microbiological aspects in its etiopathology, there are clinical reports on efficacy of aPDT in OLP patients. Multiple investigators have used aPDT regimens (5% methylene blue solution with 630 ± 5 nm diode laser, energy fluence—120 J/cm 2 per session or 5‐aminolevlinic acid 50 mg/ml with 420 nm for 10 min) with clinical benefits reported in cases of intractable OLP in patients (Aghahosseini et al., ; Bakhtiari, Mojahedi, Azari‐Marhabi, Namdari, & Rankohi, ; Mostafa, Moussa, & Alnouaem, ; Sadaksharam, Nayaki, & Selvam, ). It would be interesting to examine any therapeutic benefits of laser treatment alone in these protocols.…”

Section: Photobiomodulation Therapy In Oral Diseasesmentioning

confidence: 99%

Learning from clinical phenotypes: Low‐dose biophotonics therapies in oral diseases

et al. 2018

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This narrative review on the use of biophotonics therapies for management of oral diseases is written as a tribute to Prof. Crispian Scully. His seminal contributions to the field are highlighted by the detailed, comprehensive description of clinical presentations of oral diseases. This has enabled a more thorough, fundamental understanding of many of these pathologies by research from his group as well as inspired mechanistic investigations in many groups globally. In the same vein, a major emphasis of this narrative review is to focus on the evidence from human case reports rather than in vitro or in vivo animal studies that showcases the growing and broad impact of biophotonics therapies. The similarities and differences between two distinct forms of low-dose biophotonics treatments namely photodynamic therapy and photobiomodulation therapy are discussed. As evident in this review, a majority of these reports provide promising evidence for their clinical efficacy. However, a lack of adequate technical details, precise biological rationale, and limited outcome measures limits the current utility of these treatments. Future investigations should attempt to address these shortcomings and develop better designed, rigorous, controlled studies to fully harness the tremendous potential of low-dose biophotonics therapies.

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Interventions for treating oral lichen planus: corticosteroid therapies

Lodi

Manfredi

Mercadante

et al. 2020

Cochrane Database of Systematic Reviews

100

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Background Oral lichen planus (OLP) is a relatively common chronic T cell-mediated disease, which can cause significant pain, particularly in its erosive or ulcerative forms. As pain is the indication for treatment of OLP, pain resolution is the primary outcome for this review. This review is an update of a version last published in 2011, but focuses on the evidence for corticosteroid treatment only. A second review considering non-corticosteroid treatments is in progress. Objectives To assess the e ects and safety of corticosteroids, in any formulation, for treating people with symptoms of oral lichen planus. Search methods Cochrane Oral Health's Information Specialist searched the following databases to 25 February 2019: Cochrane Oral Health's Trials Register, CENTRAL (2019, Issue 1), MEDLINE Ovid, and Embase Ovid. ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform were searched for ongoing trials. There were no restrictions on language or date of publication. Selection criteria We considered randomised controlled clinical trials (RCTs) of any local or systemic corticosteroid treatment compared with a placebo, a calcineurin inhibitor, another corticosteroid, any other local or systemic (or both) drug, or the same corticosteroid plus an adjunctive treatment. Data collection and analysis Three review authors independently scanned the titles and abstracts of all reports identified, and assessed risk of bias using the Cochrane tool and extracted data from included studies. For dichotomous outcomes, we expressed the estimates of e ects of an intervention as risk ratios (RR), with 95% confidence intervals (CI). For continuous outcomes, we used mean di erences (MD) and 95% CI. The statistical unit of analysis was the participant. We conducted meta-analyses only with studies of similar comparisons reporting the same outcome measures. We assessed the overall certainty of the evidence using GRADE. Main results We included 35 studies (1474 participants) in this review. We assessed seven studies at low risk of bias overall, 11 at unclear and the remaining 17 studies at high risk of bias. We present results for our main outcomes, pain and clinical resolution measured at the end of Interventions for treating oral lichen planus: corticosteroid therapies (Review)

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Comparing clinical effects of photodynamic therapy as a novel method with topical corticosteroid for treatment of Oral Lichen Planus

Cited by 59 publications

References 21 publications

Photodynamic therapy in the treatment of symptomatic oral lichen planus: A systematic review

Photodynamic therapy in the treatment of symptomatic oral lichen planus: A systematic review

Learning from clinical phenotypes: Low‐dose biophotonics therapies in oral diseases

Interventions for treating oral lichen planus: corticosteroid therapies

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