Comparing Distortion Product Otoacoustic Emissions to Intracochlear Distortion Products Inferred from a Noninvasive Assay

Martin, Glen K.; Stagner, Barden B.; Dong, Wei; Lonsbury‐Martin, Brenda L.

doi:10.1007/s10162-016-0552-1

Cited by 10 publications

(6 citation statements)

References 40 publications

(41 reference statements)

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“…This suppression-induced decrease of distortion products becomes stronger as the stimulus frequency increases and approaches the tuned frequency of the measured cochlear location. The current results, however, are consistent with commonly measured distortion product otoacoustic emissions 17,67 , and the broad spectra of the electrically evoked reticular lamina vibration in living cochleae 65 . These data suggest that, under the living conditions, force production of outer hair cells is not limited by the membrane time constant 68 .…”

Section: Discussionsupporting

confidence: 89%

Two-tone distortion in reticular lamina vibration of the living cochlea

Ren

2020

Commun Biol

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It has been demonstrated that isolated auditory sensory cells, outer hair cells, can generate distortion products at low frequencies. It remains unknown, however, whether or not motile outer hair cells are able to generate two-tone distortion at high frequencies in living cochleae under the mechanical loads caused by surounding tissues and fluids. By measuring subnanometer vibration directly from the apical ends of outer hair cells using a custom-built heterodyne low-coherence interferometer, here we show outer hair cell-generated two-tone distortion in reticular lamina motion in the living cochlea. Reticular-lamina distortion is significantly greater and occurs at a broader frequency range than that of the basilar membrane. Contrary to expectations, our results indicate that motile outer hair cells are capable of generating two-tone distortion in vivo not only at the locations tuned to primary tones but also at a broad region basal to these locations.

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Section: Discussionsupporting

confidence: 89%

Two-tone distortion in reticular lamina vibration of the living cochlea

Ren

2020

Commun Biol

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“…A tentative conclusion is that having strong cochlear amplifiers, and thus, strong OAEs, may be related grossly to everyday hearing, but other, presumably neural, factors can modulate that relationship for individual listeners. The present data also confirm that the relationship between DPOAEs and hearing sensitivity is weaker than initially expected, although different measurement procedures may reveal a stronger relationship (Martin et al, 2016).…”

Section: B Correlations Between Oaes and Psychoacoustical Performancesupporting

confidence: 79%

Correlations between otoacoustic emissions and performance in common psychoacoustical tasks

McFadden

Pasanen

Maloney

et al. 2018

The Journal of the Acoustical Society of America

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Performance was measured on seven common psychoacoustical tasks for about 75 highly trained subjects. Because some psychoacoustical outcomes varied by race, the subjects were partitioned into White and Non-White categories for analysis. Sex, race, and menstrual-cycle differences in performance are described in a companion paper [McFadden, Pasanen, Maloney, Leshikar, and Pho (2018). J. Acoust. Soc. Am. 143, 2338-2354]. Also measured for all subjects were three types of otoacoustic emissions (OAEs): spontaneous otoacoustic emissions (SOAEs), click-evoked otoacoustic emissions (CEOAEs), and distortion-product otoacoustic emissions (DPOAEs). The experimental question was whether and how OAEs were correlated with psychoacoustical performance. In accord with past findings, the SOAEs and CEOAEs exhibited substantial sex and race differences, but the DPOAEs did not. Somewhat surprisingly, the correlations between OAEs and psychoacoustical performance were generally weak. No form of OAE was highly correlated with any psychoacoustical task for both sexes within a race category. Thus, there was no compelling evidence that the mechanisms underlying OAEs also contribute systematically to performance in any of the simultaneous or temporal masking tasks studied here. Especially surprising were the weak correlations between OAEs and detection of a tone in the quiet. Apparently individual differences in psychoacoustical performance reside more in post-cochlear (neural) mechanisms than in individual differences in the cochlear ("mechanical") mechanisms underlying the OAEs measured here.

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“…More constructive interference between backward-propagating DP waves occurs near the experimentally observed optimal f 2 /f 1 ratio, while destructive interference becomes pronounced at smaller f 2 /f 1 ratios, if not also at large f 2 /f 1 ratios. Similar conclusions regarding the role of wave interference in shaping DPOAEs have been reached previously through numerous modeling efforts [18-21, 24, 58] and experimental studies [59][60][61]. However, a link between the tuning of DPOAE ratio functions and cochlear vibrations has only recently been explored in a model of human DPOAE generation [24].…”

Section: Discussionsupporting

confidence: 74%

Bandpass Shape of Distortion-Product Otoacoustic Emission Ratio Functions Reflects Cochlear Frequency Tuning in Normal-Hearing Mice

Dewey

Shera

2023

JARO

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The frequency selectivity of the mammalian auditory system is critical for discriminating complex sounds like speech. This selectivity derives from the sharp tuning of the cochlea’s mechanical response to sound, which is largely attributed to the amplification of cochlear vibrations by outer hair cells (OHCs). Due to its nonlinearity, the amplification process also leads to the generation of distortion products (DPs), some of which propagate out to the ear canal as DP otoacoustic emissions (DPOAEs). However, the insight that these signals provide about the tuned micro- and macro-mechanics underlying their generation remains unclear. Using optical coherence tomography to measure cochlear vibrations in mice, we show that the cochlea’s frequency tuning is reflected in the bandpass shape that is observed in DPOAE amplitudes when the ratio of the two evoking stimulus frequencies is varied (here termed DPOAE “ratio functions”). The tuning sharpness of DPOAE ratio functions and cochlear vibrations co-varied with stimulus level, with a similar quantitative agreement in tuning sharpness observed for both apical and mid-cochlear locations. Measurement of intracochlear DPs revealed that the tuning of the DPOAE ratio functions was not caused by mechanisms that shape DPs locally near where they are generated. Instead, simple model simulations indicate that the bandpass shape is due to a more global wave interference phenomenon. It appears that the filtering of DPOAEs by wave interactions over an extended spatial region allows them to provide a window onto the frequency tuning of single cochlear locations.

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Comparing Distortion Product Otoacoustic Emissions to Intracochlear Distortion Products Inferred from a Noninvasive Assay

Cited by 10 publications

References 40 publications

Two-tone distortion in reticular lamina vibration of the living cochlea

Two-tone distortion in reticular lamina vibration of the living cochlea

Correlations between otoacoustic emissions and performance in common psychoacoustical tasks

Bandpass Shape of Distortion-Product Otoacoustic Emission Ratio Functions Reflects Cochlear Frequency Tuning in Normal-Hearing Mice

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