Tobacco use remains one of the leading preventable causes of morbidity and mortality globally, with nicotine addiction significantly impacting health outcomes. This literature review explores the multifaceted nature of tobacco use and its health implications, emphasizing the role of nursing interventions in smoking cessation. The review highlights various strategies employed by nurses, including assessment, counseling, pharmacotherapy support, and behavioral interventions, which are essential for effective tobacco cessation. By analyzing current evidence-based practices, the study underscores the importance of comprehensive assessments and personalized care plans tailored to individual patient needs. It also addresses the significance of motivational interviewing and the 5 A’s framework in facilitating successful quit attempts. In addition, the review discusses the integration of cognitive-behavioral therapy and stress management techniques as vital components of behavioral interventions. Recommendations for improving tobacco cessation efforts include enhanced training for healthcare professionals, the establishment of community-based support groups, and advocacy for robust tobacco control policies. The findings underscore the critical need for ongoing research into the long-term effectiveness of cessation interventions across diverse populations. This study aims to inform nursing practice and public health policy, ultimately contributing to the reduction of tobacco-related health issues and promoting healthier communities.