Comparing functional <scp>MRI</scp> protocols for small, iron‐rich basal ganglia nuclei such as the subthalamic nucleus at 7 <scp>T</scp> and 3 <scp>T</scp>

Hollander, Gilles de; Keuken, Max C.; Zwaag, Wietske van der; Forstmann, Birte U.; Trampel, Robert

doi:10.1002/hbm.23586

Cited by 86 publications

(96 citation statements)

References 105 publications

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“…In line with our findings, (de Hollander et al, 2017) stress that common acquisition parameters (at higher field-strength) may be optimized for specific brain regions and furthermore that brain regions differ in terms of physiological noise contributions and distance from the receiver coils. The authors did not find reliable hemodynamic responses in the brainstem's iron-rich basal ganglia nuclei during a robust stop-signal reaction task using 'standard' 7T imaging parameters.…”

Section: Discussionsupporting

confidence: 90%

“…Other studies have compared 7 T and 3 T fMRI for clinical applications (e.g. (Beisteiner et al, 2011;Morris et al, 2019) or investigated task-evoked activation related to cognition (de Hollander et al, 2017;Theysohn et al, 2013;Torrisi et al, 2018). Yet, only some of these studies have been direct head-to-head comparisons between functional measurements at the two field strengths in the same individuals.…”

Section: Introductionmentioning

confidence: 99%

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Comparing fMRI responses measured at 3 versus 7 Tesla across human cortex, striatum, and brainstem

Colizoli

Zwaag

et al. 2020

Preprint

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2 Highlights:• We compared 7 T to 3 T fMRI during perceptual decision-making under uncertainty.• Differences between 7 T and 3 T evoked responses and tSNR varied across the brain.• Evoked responses in dopaminergic brainstem nuclei were bigger at 7 T than 3 T.• The responses of dopaminergic nuclei are consistent with reward expectation.• Results highlight the potential of 7 T fMRI for imaging small brainstem nuclei. AbstractSignificant progress has been made in ultra-high field functional magnetic resonance imaging (fMRI) at 7 Tesla (T). While fMRI at 7 T promises a general increase in sensitivity compared to lower field strengths, the benefits may be most pronounced for specific applications. The current study aimed to evaluate the relative benefit of 7 T over 3 T fMRI for the assessment of task-evoked fMRI responses in different brain regions. We compared the amplitude of taskevoked responses between 3 T and 7 T measured from the same human participants.Participants performed a challenging random dot motion discrimination task with delayed monetary feedback, which animal physiology has linked to several cortical and subcortical structures including extrastriate (dorsal) visual cortical areas, the striatum, and the brainstem including dopaminergic midbrain nuclei. We quantified the evoked fMRI responses in each of these brain regions during the decision interval and the post-feedback interval of the task, and compared them between brain regions and field strengths. The dependence of response amplitudes on field strength during the decision interval differed between cortical, striatal, and brainstem regions, with a generally bigger 7 T vs. 3 T benefit in subcortical (in particular brainstem) structures. We also found stronger differential responses during easy than hard decisions at 7 T for the dopaminergic nuclei, possibly reflecting reward expectation. Our results demonstrate the potential of 7 T fMRI for illuminating the contribution of small brainstem nuclei to the orchestration of cognitive computations in the human brain.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Comparing fMRI responses measured at 3 versus 7 Tesla across human cortex, striatum, and brainstem

Colizoli

Zwaag

et al. 2020

Preprint

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“…First, an anatomically defined template of the STN region was used to explore how the STN BOLD response relates to SSRT (control) or β (choice uncertainty based on past learning) in the test phase after learning, and in the stop-signal task. The STN template was derived from a recent study using ultrahigh 7 tesla scanning 70 , and selected for its use in previous fMRI studies focusing on reinforcement based conflicted choices 13 , or response inhibition 24,25,28 .…”

Section: Fmri Analysis Procedures and Roi Selectionmentioning

confidence: 99%

Cross-task contributions of fronto-basal ganglia circuitry in response inhibition and conflict-induced slowing

Jahfari

Ridderinkhof

Collins

et al. 2017

Preprint

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Why are we so slow in choosing the lesser of two evils? We considered whether such slowing relates to uncertainty about the value of these options, which arises from the tendency to avoid them during learning, and whether such slowing relates to fronto-subthalamic inhibitory control mechanisms. 49 participants performed a reinforcement-learning task and a stop-signal task while fMRI was recorded. A reinforcement-learning model was used to quantify learning strategies. Individual differences in lose-lose slowing related to information uncertainty due to sampling, and independently, to less efficient response inhibition in the stop-signal task.Neuroimaging analysis revealed an analogous dissociation: subthalamic nucleus (STN) BOLD activity related to variability in stopping latencies, whereas weaker fronto-subthalamic connectivity related to slowing and information sampling. Across tasks, fast inhibitors increased STN activity for successfully cancelled responses in the stop task, but decreased activity for lose-lose choices. These data support the notion that fronto-STN communication implements a rapid but transient brake on response execution, and that slowing due to decision uncertainty could result from an inefficient release of this "hold your horses" mechanism.

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“…A probabilistic atlas of a specific ROI can aid optimising the scan sequence for functional imaging studies as it can be used to define the ROI and quantify specific relaxation times. For example, it has been shown that the SNR of an fMRI sequence benefits from a theoretically optimal echo time that is close to the T2* relaxation value of the region of interest (de Hollander et al, 2017). To this end, the atlas of the VTA can be applied to obtain the optimal TE by extracting the T2* values for the VTA from a T2*map.…”

Section: Future Directionsmentioning

confidence: 99%

Functional neuroanatomical review of the ventral tegmental area

et al. 2019

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License: Article 25fa pilot End User Agreement This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act (Auteurswet) with explicit consent by the author. Dutch law entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. This publication is distributed under The Association of Universities in the Netherlands (VSNU) 'Article 25fa implementation' pilot project. In this pilot research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons.

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Comparing functional MRI protocols for small, iron‐rich basal ganglia nuclei such as the subthalamic nucleus at 7 T and 3 T

Cited by 86 publications

References 105 publications

Comparing fMRI responses measured at 3 versus 7 Tesla across human cortex, striatum, and brainstem

Comparing fMRI responses measured at 3 versus 7 Tesla across human cortex, striatum, and brainstem

Cross-task contributions of fronto-basal ganglia circuitry in response inhibition and conflict-induced slowing

Functional neuroanatomical review of the ventral tegmental area

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