Blended learning, a combination of online learning and face-to-face instruction, is becoming an increasingly important component of higher education technology. However, there is currently insufficient research addressing students' perceptions of blended learning. Our study aims to investigate the satisfaction and behavioral intentions of students with blended learning in medical imaging. We employed the Technology Acceptance Model (TAM), which includes four independent variables, to evaluate students' satisfaction and behavioral intentions toward blended learning. The data were collected through the TAM survey, with questionnaires randomly distributed to the students participating in the "Medical Imaging" blended course at Hainan Medical University. A total of 145 valid questionnaires were returned and analysed via SPSS and Smart-PLS 3.3.3. Detailed results. Our results indicate that the practical application of blended learning has a positive and constructive impact and is worth promoting in higher education institutions. The empirical findings could also contribute to the integration of the TAM model to increase the effectiveness of blended learning for students.