Comparing long-term outcomes following radical and partial nephrectomy for cT1 renal cell carcinoma in young and healthy individuals

Tan, Wan-Long; Berg, Stephanie; Cole, Alexander P.; Krimphove, Marieke J.; Marchese, Marcella; Lipsitz, Stuart; Nabi, Junaid; Sammon, Jesse D.; Choueiri, Toni K.; Kibel, Adam S.; Sun, Maxine; Chang, Shin-Tsu; Trinh, Q-D.

doi:10.1016/s1569-9056(19)31027-9

Cited by 3 publications

(5 citation statements)

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“…Many of studies reported less operative time for laparoscopic nephrectomy as compared to open surgery. 18,19 In our study 2 (4%) patients need blood transfusion, 1 (2%) patient had conversion to open nephrectomy, mean hospital stay 4.32+1.45 days. One (2%) patient had wound infection.…”

Section: Discussionmentioning

confidence: 56%

Initial Experience with Laparoscopic Nephrectomy at Services Hospital Lahore

Farooq

2020

Proceedings

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Introduction: Nephrectomy means removal of kidney. Laparoscopic nephrectomy is an effective way to remove a diseased or cancerous kidney. Nephrectomy is performed to treat malignant or benign tumors of the kidney and symptomatic non functioning kidney. Laparoscopic nephrectomy is performed through transperitoneal or retroperitoneal approach. Aims & Objectives: To determine the initial experience of laparoscopic nephrectomy. Place and duration of study: Department of Urology, Services Hospital, Lahore from 1st January 2018 to 30th June 2019. Material & Methods: A total of 50 patients who underwent laparoscopic nephrectomy were included. The demographic data like age, gender, site of operation, operative time, conversion rates, postoperative complications and postoperative hospital stay were recorded. Data was analyzed using SPSS 20.0 and reported as mean± s.d, frequencies and percentages. Results: There were 28 (56%) female patients and 22 (44%) male patients. Six (12%) patients were ages <25 years, 20 (40%) were ages 25 to 40 years, 18 (36%) were ages 41 to 55 years and 6 (12%) were ages above 55 years. Non-functional kidney due to stone disease was the most common indication 35 (70%). Mean operative time was 170.43+8.45 minutes. Conversion rate was in 1 (2%) patients. Mean hospital stay was 4.32+1.45 days. Conclusion: It is concluded from this study that laparoscopic nephrectomy is safe and better technique with very low rate of complications.

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Section: Discussionmentioning

confidence: 56%

Initial Experience with Laparoscopic Nephrectomy at Services Hospital Lahore

Farooq

2020

Proceedings

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“…In general, most of the studies published in the literature so far have shown that PN is associated with a lower risk of CKD and survival benefits 2,18 . Tan et al assessed patients under age 50 who were treated for renal masses with PN and RN and reported that there was no significant difference in overall survival between the groups (HR: 0.83, 95% CI: 0.63‐1.10, P = .196) 20 . Based on their findings, the authors claimed that surgically induced CKD, rather than medical CKD, is associated with a lower risk of progression of renal insufficiency 21,22 …”

Section: Discussionmentioning

confidence: 99%

“…2,18 Tan et al assessed patients under age 50 who were treated for renal masses with PN and RN and reported that there was no significant difference in overall survival between the groups (HR: 0.83, 95% CI: 0.63-1.10, P = .196). 20 Based on their findings, the authors claimed that surgically induced CKD, rather than medical CKD, is associated with a lower risk of progression of renal insufficiency. 21,22 The present study showed a significant difference in the decrease in the GFR between the PN and RN groups, regardless of age, gender or comorbidities.…”

Section: F I G U R E 3 Os Curves According To Operation Typementioning

confidence: 99%

Factors affecting long‐term renal functions after partial vs radical nephrectomy for clinical T1 renal masses: A Multicentre Study of the Urooncology Association, Turkey

İzol

Gökalp

Sözen

et al. 2021

Int. J. Clin. Pract.

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The detection of early-stage localised T1 renal tumours has increased because of the widespread use of modern imaging procedures. This has led to higher utilisation of partial nephrectomy (PN), although radical nephrectomy (RN) remains the most commonly performed procedure for the excision of renal tumours. 1,2 According to the recent American and European guidelines, PN has become the standard treatment modality for T1 renal masses, and compared with RN, PN yields similar oncological results, superior preservation of renal function and minimisation of the long-term

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“…In addition, we have learnt the live kidney donors have similar life expectancy and cardiovascular risk after donation in comparison with age‐matched people [52]. Therefore, on the other hand a radical nephrectomy seems unlikely predispose any harm for the patient long‐term survival with rigorous assessment [53,54]. In the current urological practice, it is also observed that radical nephrectomy is still a viable option for a small renal tumour in some cases.…”

Section: Discussionmentioning

confidence: 99%

“…This is usually due to either the patient’s demand as the fear of tumour recurrence or a difficult location for in vivo laparoscopic partial nephrectomy. In United States, about 3000 kidneys with a small renal mass could be made available for transplantation after radical nephrectomy [43,53,55,56]. In UK, given increased implementation of partial nephrectomy over last decade, there was about 45% of patients underwent radical nephrectomy for T1a renal cell carcinoma, yielding about 3000 kidney grafts and some of these might have been suitable for transplantation [51,57‐59].…”

Section: Discussionmentioning

confidence: 99%

Long‐term outcome of kidney transplant by using restored kidney grafts after tumour ex vivo excision – a prospective study

Mou

et al. 2020

Transpl Int

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The aim of this study is to report long-term outcomes of kidney transplantation by using the kidney graft after a small tumour ex vivo excision. A structured programme was established to use the restored kidney graft from urological referral after radical nephrectomy. The criteria were defined as tumour size ≤3 cm, margin clear on frozen section and recipients aged ≥60 years or those on the urgent list for transplantation as a result of imminent lack of dialysis access. The recipients were followed up regularly for surveillance of tumour recurrence. Between February 2007 and February 2018, 28 recipients had kidney transplantation by using the restored kidney grafts. The tumour size was 2.6 AE 0.7 cm. The follow-up was median 7 years without evidence of tumour recurrence. The patient and graft survival was satisfactory. Kidney transplantation by using restored kidneys after a small tumour excision is a novel source for selected recipients. The long-term patient and graft survival is satisfactory. Although there is a risk of tumour recurrence, it is rare event. Together with literature review, we would support use of kidney graft after a small tumour excision for selected recipients.

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Comparing long-term outcomes following radical and partial nephrectomy for cT1 renal cell carcinoma in young and healthy individuals

Cited by 3 publications

References 0 publications

Initial Experience with Laparoscopic Nephrectomy at Services Hospital Lahore

Initial Experience with Laparoscopic Nephrectomy at Services Hospital Lahore

Factors affecting long‐term renal functions after partial vs radical nephrectomy for clinical T1 renal masses: A Multicentre Study of the Urooncology Association, Turkey

Long‐term outcome of kidney transplant by using restored kidney grafts after tumour ex vivo excision – a prospective study

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