Comparing membrane- and cantilever-based surface stress sensors for reproducibility

Loizeau, Frédéric; Akiyama, T.; Gautsch, S.; Vettiger, P.; Yoshikawa, Genki; Rooij, N. F. de

doi:10.1016/j.sna.2015.02.039

Cited by 29 publications

(25 citation statements)

References 30 publications

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“…It is also worth noting that the sensing signal of an MSS structure is robust against such fluctuation in surface stress compared to a cantilever-type structure. 22 The results shown in Figs. 9 and 10 are favorable from the view point of analysis of cell motility.…”

Section: Discussionmentioning

confidence: 94%

Finite Element Analysis on Nanomechanical Sensing of Cellular Forces

2016

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Detection of cellular forces plays an important role in investigating the mechanical basis of cells. As nanomechanical sensors can directly detect surface stress, they can be utilized to detect cellular forces. In the present study, we perform quantitative simulations of nanomechanical sensors for the detection of cellular forces using finite element analyses (FEA). We focus on two types of nanomechanical sensors: a cantilever-type sensor and a membrane-type surface stress sensor (MSS). It is found that sensing signals can be obtained when cells on the nanomechanical sensors synchronize their motions. To effectively detect cellular forces on the nanomechanical sensors, we discuss the optimization scheme for a coating layer on the surface of the sensors.

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Section: Discussionmentioning

confidence: 94%

Finite Element Analysis on Nanomechanical Sensing of Cellular Forces

2016

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“…In contrast, a compact measurement system can be realized with an MSS because of the chip-integrated piezoresistive electric sensing. Furthermore, MSS exhibits higher robustness to the adsorption position and in homogeneous coating (Loizeau et al, 2015 ). Thus, MSS seems to be a more favorable option for practical applications such as mobile environmental monitoring systems, point-of-care-testing (POCT) and primary screening for infectious diseases, etc.…”

Section: Discussionmentioning

confidence: 99%

Finite Element Analysis on Nanomechanical Detection of Small Particles: Toward Virus Detection

2016

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Detection of small particles, including viruses and particulate matter (PM), has been attracting much attention in light of increasing need for environmental monitoring. Owing to their high versatility, a nanomechanical sensor is one of the most promising sensors which can be adapted to various monitoring systems. In this study, we present an optimization strategy to efficiently detect small particles with nanomechanical sensors. Adsorption of particles on the receptor layer of nanomechanical sensors and the resultant signal are analyzed using finite element analysis (FEA). We investigate the effect of structural parameters (e.g., adsorption position and embedded depth of a particle and thickness of the receptor layer) and elastic properties of the receptor layer (e.g., Young's modulus and Poisson's ratio) on the sensitivity. It is found that a membrane-type surface stress sensors (MSS) has the potential for robust detection of small particles.

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“…Investigations into the performance of cantilever based sensors has reiterated the importance of the functionalisation method by comparing cantilever sensors with membrane-type surface stress sensors [16]. Cantilever sensor technology has also recently been applied in the detection of a veterinary drug kanamycin using aptamer-based cantilever array sensors [17].…”

Section: Introductionmentioning

confidence: 99%

Microcantilever arrays functionalised with spiropyran photoactive moieties as systems to measure photo-induced surface stress changes

Grogan¹,

Florea

Koprivica

et al. 2016

Sensors and Actuators B: Chemical

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Herein we investigate the feasibility of detecting photo-induced surface stress changes using the deflection response of cantilevers. For this purpose, silicon microcantilevers have been functionalised with spiropyran photochromic molecules, using both a monolayer and a polymeric brushes approach. Upon ultraviolet light irradiation, the spiropyran unit is converted to the merocyanine form due to the photo-induced cleavage of the C spiro -O bond. The two forms of the molecule have dramatically different charge, polarity and molecular conformations. This makes spiropyrans an ideal system to study the correlation between photo-induced molecular changes and corresponding changes in surface stress. Our investigations include monitoring the changes in static cantilever deflection, and consequently, surface stress of the spiropyran functionalised cantilevers on exposure to ultraviolet light. Cantilever deflection data reveals that ultraviolet induced conformational changes in the spiropyran moiety cause a change in compressive surface 2 stress and this varies with the type of functionalisation method implemented. The change in surface stress response from the spiropyran polymer brushes functionalised cantilevers gives an average surface stress change of 98 Nm -1 (n = 8) while the spiropyran monolayer coated cantilevers have an average surface stress change of about 446 Nm -1 (n = 24) upon irradiation with UV light.

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Comparing membrane- and cantilever-based surface stress sensors for reproducibility

Cited by 29 publications

References 30 publications

Finite Element Analysis on Nanomechanical Sensing of Cellular Forces

Finite Element Analysis on Nanomechanical Sensing of Cellular Forces

Finite Element Analysis on Nanomechanical Detection of Small Particles: Toward Virus Detection

Microcantilever arrays functionalised with spiropyran photoactive moieties as systems to measure photo-induced surface stress changes

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