Comparing methods for monitoring serum creatinine to predict late renal allograft failure

Kasiske, Bertram L.; Andany, Magdalena Adeva; Hernández, Domingo; Silkensen, John R.; Rabb, Hamid; McClean, Jeffrey C.; Roel, Joseph P.; Danielson, Barbara

doi:10.1053/ajkd.2001.28605

Cited by 36 publications

(32 citation statements)

References 7 publications

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“…Few studies, however, have investigated measures of chronic change in renal allograft function. A recent report compared the predictive value of early and late measures of renal function and found that late changes in 1/SCr show the strongest association with long-term graft survival (7).…”

mentioning

confidence: 99%

Mycophenolate mofetil versus azathioprine therapy is associated with a significant protection against long-term renal allograft function deterioration1

et al. 2003

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mentioning

confidence: 99%

Mycophenolate mofetil versus azathioprine therapy is associated with a significant protection against long-term renal allograft function deterioration1

et al. 2003

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“…The independent relative risk for graft failure attributable to Delta1/Cr less than -40% was 5.91 (95% confidence interval, 3.25 to 10.8; P < .0001). 17 The prevalence of proteinuria is variable. Twenty to 28% of patients with CAI have greater than 0.5 g proteinuria per 24 hours compared with 6 to 8% of patients free of CAI.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…10 Halloran and associates defined CAN as a state of an impaired graft function at least 3 months after an RT, but independent of acute rejection, drug toxicity, recurrence of de novo specific disease entities with typical histological features such as tubular atrophy (TA), interstitial fibrosis (IF), fibrous intimal thickening, and transplant glomerulopathy. 11 The 8th Banff Conference on allograft pathology held in Edmonton, Canada, July [15][16][17][18][19][20][21]2005, introduced the term chronic allograft injury (CAI) to replace CAN, as the term CAN was being used as a generic term for all causes of CAD with fibrosis, which inhibited accurate diagnosis and appropriate therapy. 12 Histologically, the term CAN was replaced by interstitial fibrosis (IF) and tubular atrophy (TA).…”

Section: Introductionmentioning

confidence: 99%

Untitled

Shrestha

Haylor²

2016

Exp Clin Transplant

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The advantages conferred by renal transplant, such as the improved quality of life and survival, are compromised by the reduced half-life of the transplanted kidney to a decade because of chronic allograft injury, which is the leading cause of transplant loss. There has been a significant evolution in the concept of the nomenclature, grading of histologic changes, diagnostic markers, and the theories of the pathogenesis of chronic allograft injury in the past decade. This review sought to consolidate the published literature that contributes toward under standing the changing concepts and pathogenesis of the chronic allograft injury, which has implications to managing and preventing chronic allograft injury in experimental and clinical settings.

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“…However, a rise in serum creatinine is a late sign of renal injury because compensatory mechanisms within the kidney can maintain glomerular filtration rate (GFR) despite progressive structural injury (5)(6)(7). The ability to detect CAN is limited by the fact that biopsies usually are not performed unless there has been an elevation in serum creatinine (3,(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

“…The ability to detect CAN is limited by the fact that biopsies usually are not performed unless there has been a reduction in creatinine clearance (3,(5)(6)(7). Further, the diagnosis of CAN according to Banff criteria lacks the sensitivity to detect renal injury as it relies on a semiquantitative assessment of renal fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Gene Panel mRNAs in Urine Samples of Kidney Transplant Recipients as a Non-invasive Tool of Graft Function

Mas

Archer

et al. 2007

Mol Med

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Non-invasive monitoring may be useful after kidney transplantation (KT), particularly for predicting acute rejection (AR). It is less clear whether chronic allograft nephropathy (CAN) is also associated with changes in urine cells. To identify non-invasive markers of allograft function in kidney transplant patients (KTP), mRNA levels of AGT, TGF-β1, EGFR, IFN-γ, TSP-1, and IL-10 in urine (Ur) samples were studied using QRT-PCR. Ninety-five KTP and 111 Ur samples were evaluated. Patients (Pts) were divided as, within six months (N = 31), and with more than six months post-KT (N = 64). KTP with more than six months post-KT were classified as KTP with stable kidney function (SKF) (N = 32), KTP with SKF (creatinine < 2 mg/dL) and proteinuria > 500 mg/24 h (N = 18), and KTP with biopsy proven CAN (N = 14). F-test was used to test for equality of variances between groups. IL-10 mRNA was decreased in Ur samples from KTP with less than six months post-KT (P = 0.005). For KTR groups with more than six months post-KT, AGT and EGFR mRNA were statistically different among KTP with SKF, KTP with SKF and proteinuria, and CAN Pts (P = 0.003, and P = 0.01), with KTP with SKF having higher mean expression. TSP-1 mRNA levels also were significantly different among these three groups (P = 0.04), with higher expression observed in CAN Pts. Using the random forest algorithm, AGT, EGFR, and TGF-β1 were identified as predictors of CAN, SKF, SKF with proteinuria. A characteristic pattern of mRNA levels in the different KTP groups was observed indicating that the mRNA levels in Ur cells might reflect allograft function.

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Comparing methods for monitoring serum creatinine to predict late renal allograft failure

Cited by 36 publications

References 7 publications

Mycophenolate mofetil versus azathioprine therapy is associated with a significant protection against long-term renal allograft function deterioration1

Mycophenolate mofetil versus azathioprine therapy is associated with a significant protection against long-term renal allograft function deterioration1

Untitled

Evaluation of Gene Panel mRNAs in Urine Samples of Kidney Transplant Recipients as a Non-invasive Tool of Graft Function

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