Comparing mortality outcomes of major burns and toxic epidermal necrolysis in a tertiary burns centre

Mahar, Patrick; Wasiak, Jason; Paul, Eldho; Watters, David; Kirby, Julia C; Gin, Douglas L.; Marsh, Philip; Cleland, Heather

doi:10.1016/j.burns.2014.03.012

Cited by 10 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…19,20 However, several complications of SJS/TEN can result in death, including metabolic imbalance, sepsis, pulmonary embolus, renal failure, hematologic abnormalities, and gastrointestinal hemorrhage. 21,22 During admission, the SCORTEN (SCORe of Toxic Epidermal Necrosis) is used to evaluate the risk of death on the basis of seven clinical and biological parameters. 23 The seven risk factors considered are age above 40 years, malignancy, tachycardia above 120 beats per minute, initial percentage of epidermal detachment greater than 10% TBSA, serum urea above 10 mmol per liter, serum glucose above 14 mmol per liter, and serum bicarbonate below 20 mmol per liter.…”

Section: Supportive Medical Carementioning

confidence: 99%

Multidisciplinary care in Stevens-Johnson syndrome

Shanbhag

Chodosh

Fathy

et al. 2020

Therapeutic Advances in Chronic Disease

View full text Add to dashboard Cite

Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are potentially fatal mucocutaneous diseases that can involve many organ systems. Manifestations of SJS/TEN outside of the skin, eyes, and oral mucosa are not well defined or well recognized, and, therefore, are often not addressed clinically. As supportive care improves and mortality from SJS/TEN decreases, chronic complications in affected organ systems are becoming more prevalent. Recognition of the manifestations of SJS/TEN in the acute phase is critical to optimal care. In this review, we review the organ systems that may be involved in SJS/TEN, provide an overview of their management, and propose a list of items that should be communicated to the patient and family upon discharge. The organ systems discussed include the pulmonary, gastrointestinal/hepatic, oral, otorhinolaryngologic, gynecologic, genitourinary, and renal systems. In addition, the significant psychosocial, nutritional, and pain consequences and management of SJS/TEN are discussed.

show abstract

Section: Supportive Medical Carementioning

confidence: 99%

Multidisciplinary care in Stevens-Johnson syndrome

Shanbhag

Chodosh

Fathy

et al. 2020

Therapeutic Advances in Chronic Disease

View full text Add to dashboard Cite

show abstract

“…It has been reported that mortality rates for major burn injuries have decreased in recent years due to a better understanding of burn pathophysiology and advanced monitoring techniques. While in the past, a 50% mortality rate was reported for a TBSA of 30% in healthy young adults, this went up to a TBSA of 80% today [ 9 , 10 ]. This fact indicates a great development in the management of patients with major burns compared to past years.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Albumin and Fresh Frozen Plasma as Colloid Therapy in Patients With Major Burns

Vural¹,

Yasti²,

Dolapci³

2023

Cureus

View full text Add to dashboard Cite

Background: Burn injuries are one of the main causes of morbidity and mortality throughout the world, and burn patients have higher chances of recovery if they are treated with effective fluid and colloid management. Fresh frozen plasma (FFP) and albumin suspension used as a colloid treatment agent are very useful for the treatment of severe burns.Methods: This retrospective clinical trial was conducted at the Numune Education and Research Hospital Burn Center, Ankara, Turkey. Two hundred and nine patients who had severe burns that involved more than 30% of their total body surface area (TBSA) were studied. After the first 24 hours, 13 patients were deceased, leaving 196 patients remaining in the study, including 139 patients in the fresh frozen plasma group and 57 patients in the albumin group. Both the fresh frozen plasma and albumin groups received the standard therapy of the burn center, which was based on a standard protocol. Then, these patients were compared according to their clinical findings and mortality.Results: There were no significant differences between the groups with respect to age, gender, and comorbidities. The laboratory findings, blood, urine, and wound culture results were also similar between groups. The mortality rate was higher in the group receiving albumin than in the group receiving fresh frozen plasma (78.9% and 33.8%, respectively; p=0.0007).Conclusions: According to this study, there was a significant relationship between the improvement in mortality and the mode of colloid treatment in patients with major burns.

show abstract

“…En la nuestra es del 28% pero al considerar sólo los cuadros de NET llega al 46%. Esta mortalidad es mayor al de una serie de 708 enfermos de NET, donde el 30% falleció, siendo la sepsis y la falla multiorgánica las principales causas (11).…”

Section: Discusionunclassified

“…El mecanismo es apoptosis generalizada de los queratinocitos provocada por una reacción citotóxica mediada por células y amplificada por las citocinas (1,2,9). La incidencia de la NE es muy baja (SSJ 1 a 6 casos por millón de habitantes /año y NET 0.4 a 1.2 por millón/año) pero la mortalidad es alta (SSJ 5 a 12% y NET más del 30%) (10,11).…”

unclassified

Necrólisis cutánea - Casuística de 25 años

Caballero

Negrete

2019

An. Fac. Cienc. Méd. (Asunción)

View full text Add to dashboard Cite

Introducción: La Necrólisis Epidérmica es una reacción grave y potencialmente mortal, inducida sobre todo por fármacos. Incluye 2 cuadros que presentan similitudes histológicas, etio-patogénicas, pero difieren en el porcentaje de piel afectada: el Síndrome de Stevens-Johnson y la Necrólisis Epidérmica Tóxica. Existen cuadros intermedios entre ambas entidades. El objetivo del trabajo es comunicar las características clínico-epidemiológicas de los casos de Necrólisis Epidérmica registrados en el Hospital Nacional en un periodo de 25 años. Materiales y Métodos: Estudio retrospectivo, descriptivo de los casos de Necrólisis Epidérmica en sus variantes Síndrome de Stevens-Johnson, Necrólisis Epidérmica Tóxica y cuadros intermedios registrados en el Servicio de Dermatología del Hospital Nacional en el periodo 1992-2017. Resultados: Se registraron 46 casos, 27 de Stevens-Johnson, 15 de Necrólisis Epidérmica Tóxica y 4 intermedios. Los casos se observaron en ambos sexos por igual, con edad media de 26,7años (DE 20,69). Los fármacos involucrados con más frecuencia fueron los antibióticos en 16 casos (penicilina y derivados en primer lugar), los anticonvulsivantes (13 casos) predominando la difenilhidantoina y antiinflamatorios-analgésicos (11 casos). El tratamiento consistió en medidas generales en todos, corticoides sistémico en 21 casos y gammaglobulina en 3. La mortalidad global fue del 28%, llegando al 46% en la Necrólisis Epidérmica Tóxica. Conclusiones: La Necrólisis Epidérmica es un cuadro poco frecuente pero grave, con elevada mortalidad, causado principalmente por antibióticos y anticonvulsivantes en esta serie, al igual que en la mayoría de otras series

show abstract

Comparing mortality outcomes of major burns and toxic epidermal necrolysis in a tertiary burns centre

Cited by 10 publications

References 22 publications

Multidisciplinary care in Stevens-Johnson syndrome

Multidisciplinary care in Stevens-Johnson syndrome

Comparison of Albumin and Fresh Frozen Plasma as Colloid Therapy in Patients With Major Burns

Necrólisis cutánea - Casuística de 25 años

Contact Info

Product

Resources

About