Comparing Occlusive Balloon Performance Using 3-Dimensional Printed Models of Intracranial Aneurysmal Defects

Knox, Joseph; Sincic, Ryan; McCoy, David; Sostarich, Colby; Cooke, Daniel L

doi:10.1016/j.wneu.2020.11.030

Cited by 2 publications

(3 citation statements)

References 11 publications

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“…Knox et al compared three CBs, with Scepter C showing the highest compliance and improved compliance as the hole size increased. 11 This result differs from ours, which showed no significant difference in pressure between TransForm C and Scepter C in the straight model when the hole size was 3 mm (vascular models A and C). However, when the hole size was increased (vascular model B), the pressure of Scepter C was significantly lower than that of TransForm C, which was similar to that of Knox et al; the tendency may also be similar in terms of pressure changes due to hole size.…”

Section: Discussioncontrasting

confidence: 95%

“…We found that the pressure on the vessel wall when the balloon was inflated varied between the different balloons and that vessel shape and diameter, and hole size, affected the pressure. Only one similar study was previously published; 11 however, our report is the first to compare SCBs. In this experiment, the pressure applied to the vessel wall was directly measured, which more accurately reflects the damage to the vessel wall.…”

Section: Discussionmentioning

confidence: 83%

“…The pressure applied to the vessel wall decreased for all balloons as the hole size increased. The report by Knox et al 11 similarly shows that larger holes improve compliance and reasons that the larger the hole, the larger the range through which the balloon can pass.…”

Section: Discussionmentioning

confidence: 96%

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Evaluation of the differences in pressure applied to the vessel wall by different types of balloon remodeling microcatheters in an experimental model

et al. 2021

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Background We examined compliance differences among balloon remodeling microcatheters, which have not been established previously. Methods Straight and 120° angulated vascular models were created in a 3 mm diameter tube with 3 mm hole (vascular model A), a tube with a 4 mm hole (vascular model B), and a 4 mm diameter tube (vascular model C). We compared the pressure exerted when each balloon was herniated 1 or 2 mm between three compliant balloons (SHOURYU SR, TransForm C, and Scepter C) and four super-compliant balloons (HyperForm, SHOURYU HR, TransForm SC, and Scepter XC). Results In vascular model A, there was a significant difference in the pressure exerted by compliant balloons and super-compliant balloons in both the straight and angulated models. In the straight model (1 and 2 mm), the lowest pressure was exerted by HyperForm (super-compliant balloons group) and SHOURYU SR (compliant balloons group). The lowest pressure was exerted in the angulated model by HyperForm (super-compliant balloons group) and Scepter C (compliant balloons group). The Scepter balloon exerted higher pressure in the straight model than other balloon remodeling microcatheters but less in the angulated model. In vascular model B, the pressure decreased in all balloons compared with model A. In vascular model C, the pressure increased in all balloons compared with model A. Conclusions Pressure differed across balloon remodeling microcatheters. In addition, vessel shape and diameter, and hole size, affected the results. Our findings can help select balloon remodeling microcatheters.

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Section: Discussioncontrasting

confidence: 95%

Section: Discussionmentioning

confidence: 83%

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Evaluation of the differences in pressure applied to the vessel wall by different types of balloon remodeling microcatheters in an experimental model

et al. 2021

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Isolation and focal treatment of brain aneurysms using interfacial fluid trapping

Khoury,

Mekler,

Epshtein

et al. 2024

Sci. Adv.

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Current approaches for localized intravascular treatments rely on using solid implants, such as metallic coils for embolizing aneurysms, or on direct injection of a therapeutic agent that can disperse from the required site of action. Here, we present a fluid-based strategy for localizing intravascular therapeutics that leverages surface tension and immiscible fluid interactions, to allow confined and focal treatment at brain aneurysm sites. We first show, computationally and experimentally, that an immiscible phase can be robustly positioned at the neck of human aneurysm models to seal and isolate the aneurysm’s cavity for further treatment, including in wide-neck aneurysms. We then demonstrate localized delivery and confined treatment, by selective staining of cell nuclei within the aneurysm cavity as well as by hydrogel-based embolization in patient-specific aneurysm models. Altogether, our interfacial flow-driven strategy offers a potential approach for intravascular localized treatment of cardiovascular and other diseases.

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Comparing Occlusive Balloon Performance Using 3-Dimensional Printed Models of Intracranial Aneurysmal Defects

Cited by 2 publications

References 11 publications

Evaluation of the differences in pressure applied to the vessel wall by different types of balloon remodeling microcatheters in an experimental model

Evaluation of the differences in pressure applied to the vessel wall by different types of balloon remodeling microcatheters in an experimental model

Isolation and focal treatment of brain aneurysms using interfacial fluid trapping

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