“…Across all included studies, a total of 3332 patients were assessed. DEX was used as an adjuvant to several different local anesthetics, which included ropivacaine [ 23 , 34 , 39 , 41 , 42 , 45 – 47 , 49 , 50 , 52 , 56 , 57 , 59 , 63 – 66 , 68 , 72 – 74 , 76 , 78 , 80 , 81 , 84 , 85 ], bupivacaine [ 20 , 35 , 37 , 38 , 40 , 51 , 53 – 55 , 67 , 69 , 71 ], levobupivacaine [ 21 , 43 , 44 , 48 , 60 – 62 , 79 , 83 ], and lidocaine [ 22 , 36 , 70 , 77 , 86 ]. Across the studies, the dose of DEX ranged from 0.5 μg/kg to a total of 150 μg.…”