Comparing potential of Ficus carica and Allium sativum on triglyceride to HDL ratio in high fat diet fed male Wistar Albino rats

Abstract

Present study compares the potential of Ficus carica and Allium sativum on triglyceride to HDL ratio in high fat diet fed male Wistar albino rats. A sample of 36 male Wistar albino rats was randomly divided into 6 groups (A, B, C, D, E and F). Hyperlipidemia was induced by high fat diet (HFD) (banaspati ghee + coconut oil) mixed in normal chow diet. After six weeks, blood was taken through retro – orbital capillary plexus, centrifuged to get sera, stored at -20°C temperature for biochemical analysis of blood lipids. TAG/HDLc ratio (atherogenic index of plasma) was measured as log TAG/HDLc. Statistical package (SPSS ver. 21.0, IBM, incorporation, USA) analyzed the results by 1- ANOVA and post – Hoc Benforinni test (p≤ 0.05). Cholesterol, TAGs, LDLc, and HDLc shows significant decrease in F. carica and A. sativum treated experimental groups C – F compared to positive controls (P=0.0001). A. sativum shows more potent hypolipidemic potential and more significant reduction in TAG/HDLc ratio compared to F. carica (P=0.0001). The present study concludes Ficus carica and Allium sativum show hypolipidemic potential with significant decrease in TAG/HDLc ratio and they may be used to prevent atherosclerosis and coronary artery disease as simple home remedy.