Comparing prophylactic use of cefazolin for SSI in cesarean section: a systematic review and meta-analysis

Li, Meilin; Shi, Bingzhi; Ma, Jing; Peng, Xinyue; Shi, Jiemin

doi:10.1007/s00404-020-05873-z

Cited by 7 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These genes were positively associated with the presence of AZI-resistant Staphylococcus aureus. Moreover, other authors have also reported a higher prevalence of Vim-1 (conferring β-lactamase resistance) in the oral microbiome of their cohort of babies exposed to IAP [33] .…”

Section: Impact Of Iap On the Developing Infant Resistomementioning

confidence: 82%

See 1 more Smart Citation

Impact of intrapartum antibiotics on the developing microbiota: a review

Arboleya¹,

Saturio²,

Gueimonde³

2022

Microbiome Res Rep

View full text Add to dashboard Cite

The perinatal period sets the basis for the later physiological and immune homeostasis of the individual, with the intestinal microbiota being an important contributor to driving this homeostasis development. Therefore, the initial establishment and later development of the microbiota during early life may play a key role in later health. This early establishment of the intestinal microbiota is known to be affected by several factors, with gestational age, delivery mode, and feeding habits being extensively studied ones. Other factors are not so well understood, although knowledge has been accumulating in the last years. Among them, a factor of great relevance is the effect of perinatal exposure to antibiotics. Administration of intrapartum antimicrobial prophylaxis (IAP) to women during the delivery process represents the most common form of exposure to antibiotics during the perinatal period, present in around 30% of deliveries. During the last decade, evidence has accumulated demonstrating that IAP alters intestinal microbiota development in neonates. Moreover, recent evidence indicates that this practice may also be altering the infant intestinal resistome by increasing the levels of some antibiotic resistance genes. This evidence, as reviewed in this manuscript, suggests the interest in promoting the rational use of IAP. This practice has significantly reduced the risk of neonatal infections, but now the accumulating knowledge suggests the need for strategies to minimize its impact on the neonatal microbiota establishment.

show abstract

Section: Impact Of Iap On the Developing Infant Resistomementioning

confidence: 82%

“…children at 2-5 years [32] . Beyond gut microbiota, some studies have also been published showing differences in the infant oral microbiota due to maternal intrapartum antibiotics [33,34] .…”

Section: Impact Of Iap On the Developing Microbiota Compositionmentioning

confidence: 99%

Impact of intrapartum antibiotics on the developing microbiota: a review

Arboleya¹,

Saturio²,

Gueimonde³

2022

Microbiome Res Rep

View full text Add to dashboard Cite

show abstract

“…In 2020, Li 20 published a meta‐analysis showed that giving cefazolin before incision reduces surgical site infections after CS. Sun 21 published a meta‐analysis in 2013 showed that the prophylactic use of cefazolin reduced endometritis after CS.…”

Section: Discussionmentioning

confidence: 99%

Effect of prophylactic use of cefazolin in caesarean section on postoperative infection: A meta‐analysis

Lv,

Ren,

et al. 2024

International Wound Journal

View full text Add to dashboard Cite

Caesarean section rate is increasing and postoperative wound infection is a major health‐threatening complication after caesarean section (CS). The aim of this study was to evaluate the efficacy of Cefazolin at different time for post‐caesarean delivery. The aim of this study was to compare the use of Cefazolin at different times on infections after CS. The time of antibiotic use in CS can be divided into two groups: before skin incision (SI) and after cord clamping (CC). In this study, 268 relevant articles were found in the database, and finally, 10 articles were analysed. This study included a total of 5256 cases of caesarean section. The data on wound infections, endometritis, urinary tract infections and fever were analysed. Perform an analysis of the data using RevMan 5.3. The results showed that cefazolin before SI reduced wound infection compared to after CC (odds ratio [OR], 0.51; 95% CI: 0.37–0.69; p < 0.0001). Cefazolin prophylactically used before SI reduce endometritis after CS compared to after CC (OR, 0.52; 95% CI: 0.35–0.77; p = 0.001). There was no significant difference in urinary tract infections after CS between cefazolin prophylactically used before SI and after CC (OR, 0.80; 95% CI: 0.50–11.28; p = 0.35). There was no significant difference in fever after CS between the prophylactic use of cefazolin before SI and after CC (OR, 0.60; 95% CI: 0.26–11.43; p = 0.225). Cefazolin before SI reduces wound infection and endometritis after CS.

show abstract

“…20 A meta-analysis involving 16,328 pregnant women who underwent CS showed that cefazolin prophylaxis might reduce the risk of post-SC surgical site infection (SSI). 21 Two obstetricians still used amoxicillin-clavulanate as prophylactic antibiotics, contrary to the WHO recommendations, which prohibit amoxicillinclavulanate as a prophylactic antibiotic because it increases the risk of necrotizing enterocolitis, particularly in preterm infants. 5 Most obstetricians used cefazolin as a prophylactic antibiotic at 2 g intravenously.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Use in Caesarean Section among Obstetricians and Gynaecologists in the Second Largest City in Indonesia

Tjokroprawiro

Akbar

Ulhaq

et al. 2023

Indones J Obstet Gynecol

View full text Add to dashboard Cite

Objective: To evaluate the pattern of antibiotic use incesarean section `by obstetricians in Surabaya, Indonesia.Methods: This was a descriptive observational study witha cross-sectional method. Study data were obtained fromonline interviews using electronic forms. This study useda total sampling method taken from obstetricians andgynecologists in Surabaya, Indonesia. The primary outcomeof this study was a pattern of antibiotic use, includingprophylactic use, selection of antibiotics, the timing ofadministration, additional antibiotics during and aftersurgery, and consideration of choice.Results: The majority of antibiotics used in CS are in linewith the guidelines. The types of prophylactic antibiotics(iv) used are varied; the majority were cefazoline (74.5%),ceftriaxone (14.5%), and cefotaxime (11.6%). Most antibioticswere administered <30 minutes before surgery. 2.5% ofobstetricians routinely added antibiotics during a cesarean,while 33% were based on a particular condition such asprolonged surgery, massive bleeding, or risk of infections.The selection of antibiotics by obstetricians was based onprotocols followed in the hospital (44.5%).Conclusion: This study demonstrates that most obstetriciansutilized antibiotic prophylaxis appropriately and followedguidelines for Cesarean Section.Keywords: antibiotic, cesarean section, maternal health,obstetricians.AbstrakTujuan: Untuk mengevaluasi pola penggunaan antibiotikpada seksio sesarea oleh dokter kandungan di Surabaya,Indonesia.Metode: Ini merupakan studi deskriptif observasionaldengan metode pengambilan data potong lintang. Datastudi diperoleh dari wawancara online dengan menggunakanformulir elektronik. Studi ini menggunakan total samplingdari dokter obstetri dan ginekologi di Surabaya, Indonesia.Hasil utama dari penelitian ini adalah pola penggunaanantibiotik, termasuk penggunaan profi laksis, pemilihanantibiotik, waktu pemberian, antibiotik tambahan selamadan setelah operasi, dan pertimbangan pilihan antibiotiktersebut.Hasil: Mayoritas antibiotik yang digunakan pada seksiosesarea sesuai dengan pedoman. Jenis antibiotik profi laksis(iv) yang digunakan bervariasi, mayoritas adalah cefazoline(74,5%), ceftriaxone (14,5%), dan cefotaxime (11,6%).Sebagian besar antibiotik diberikan <30 menit sebelumoperasi. 2,5% dokter kandungan rutin menambahkanantibiotik saat operasi sesar, sedangkan 33% didasarkanpada kondisi tertentu seperti operasi yang berkepanjangan,perdarahan masif, atau risiko infeksi. Pemilihan antibiotikoleh dokter kandungan berdasarkan protokol yang diikutidi rumah sakit (44,5%).Kesimpulan: Studi ini menunjukkan bahwa sebagian besardokter kandungan menggunakan profi laksis antibiotikdengan tepat dan mengikuti pedoman untuk operasi seksiosesaria.Kata kunci: antibiotik, dokter kandungan, kesehatan ibu,operasi sesar.

show abstract

Comparing prophylactic use of cefazolin for SSI in cesarean section: a systematic review and meta-analysis

Cited by 7 publications

References 18 publications

Impact of intrapartum antibiotics on the developing microbiota: a review

Impact of intrapartum antibiotics on the developing microbiota: a review

Effect of prophylactic use of cefazolin in caesarean section on postoperative infection: A meta‐analysis

Antibiotic Use in Caesarean Section among Obstetricians and Gynaecologists in the Second Largest City in Indonesia

Contact Info

Product

Resources

About