Comparing Rates of Change in Moderate to Advanced Glaucoma: Retinal Nerve Fiber Layer Versus Bruch Membrane Opening-Minimum Rim Width

Shi, Lynn; Mohammadi, Massood; Mohammadzadeh, Vahid; Su, Erica; Weiss, Robert E.; Nouri‐Mahdavi, Kouros

doi:10.1016/j.ajo.2023.05.003

Cited by 6 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To the best of our knowledge, there is a scarcity of normative OCT data available for children, A B The findings regarding the identification of structural deterioration indicative of glaucoma progression suggest that RNFL thickness is more likely than BMO-MRW to exhibit a declining trend over time. Globally and within inferior and superonasal sectors, the longitudinal signal-to-noise ratios for RNFL were more negative than those of BMO-MRW, meaning that the information within longitudinal RNFL thickness measurements is less noisy compared with that of BMO-MRW [8].…”

Section: Evaluating Oct Data With a Normative Databasementioning

confidence: 87%

Current Status and Future Perspectives of Optic Nerve Imaging in Glaucoma

Lommatzsch,

van Oterendorp

2024

JCM

View full text Add to dashboard Cite

Being the primary site of degeneration, the optic nerve has always been the focus of structural glaucoma assessment. The technical advancements, mainly of optical coherence tomography (OCT), now allow for a very precise quantification of the optic nerve head and peripapillary retina morphology. By far the most commonly used structural optic nerve parameter is the thickness of the parapapillary retinal nerve fiber, which has great clinical utility but also suffers from significant limitations, mainly in advanced glaucoma. Emerging novel imaging technologies, such as OCT angiography, polarization-sensitive or visible-light OCT and adaptive optics, offer new biomarkers that have the potential to significantly improve structural glaucoma diagnostics. Another great potential lies in the processing of the data already available. Artificial intelligence does not only help increase the reliability of current biomarkers but can also integrate data from various imaging modalities and other clinical measures to increase diagnostic accuracy. And it can, in a more efficient way, draw information from available datasets, such as an OCT scan, compared to the current concept of biomarkers, which only use a fraction of the whole dataset.

show abstract

Section: Evaluating Oct Data With a Normative Databasementioning

confidence: 87%

Current Status and Future Perspectives of Optic Nerve Imaging in Glaucoma

Lommatzsch,

van Oterendorp

2024

JCM

View full text Add to dashboard Cite

show abstract

“…Some of these differences may be explained by the type of glaucoma being analysed. In the most frequent forms of glaucoma, it has been described that RNFL detects progression better than BMO-MRW [ 19 ], but specifically in normal-tension glaucoma, the opposite has been found [ 20 ]. In our study, the results were clearly oriented towards the latter conclusion, although it is questionable whether this is a specific feature of all normal-tension glaucomas.…”

Section: Discussionmentioning

confidence: 99%

Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis

Gonzalez-Hernandez,

Betancor-Caro,

Mesa-Lugo

et al. 2023

JCM

View full text Add to dashboard Cite

Background: Previous retrospective results are evaluated prospectively and blinded. Methods: A total of 221 eyes previously classified as normal (G1), 279 as moderate risk of glaucoma (G2) and 217 as high risk (G3) according to the Globin Discriminant Function (GDF) Laguna-ONhE index were examined with OCT Spectralis- Results: In G1, the Bruch’s Membrane Opening Minimum Rim Width (BMO-MRW) was 332 ± 55 microns; in G2, it was 252 ± 47 (p < 0.0001); and in G3, 231 ± 44 (p < 0.0001). In G1, the 1% and 5% percentiles were 233 and 248, respectively; in G2, they were lower in 28.80% and 42.29% of cases, respectively; and in G3, in 50.23% and 63.59% of cases, respectively. Most of the cases were normal-tension glaucomas. Laguna-ONhE indices showed a curvilinear correlation with BMO-MRW results. The Retinal Nerve Fibre Layer (RNFL) showed a poor relationship with BMO. Assuming G1 to be truly normal, BMO-MRW would have a Receiver operating characteristic (ROC) curve area of 0.901 for G2 and G3 and 0.651 for RNFL. A significant reduction in pixels corresponding to vessels was found in G2 and G3 vs. G1 (p < 0.0001). Conclusions: In some cases, these defects appear to be mainly glaucomatous, and in others, they are associated with diabetic microangiopathy. In normal tension glaucoma, RNFL defects may be less severe than those inside the nerve.

show abstract

“… 12 MRW has also been reported to show earlier detectable change than RNFLT in early-stage glaucoma, 3 and the rate of change of MRW has been found to be consistently greater than RNFLT in patients with early normal-tension glaucoma (NTG). 13 However, Shi et al 14 reported that RNFLT is more likely than MRW to reveal a declining trend over time in patients with central or moderate-to-advanced glaucomatous damage. The potential time lag between MRW and RNFLT alterations underscores the complexity of glaucomatous progression and highlights the need for comprehensive assessments that consider the distinct dynamics of these parameters.…”

Section: Introductionmentioning

confidence: 99%

The Temporal Relation Between Rates of Retinal Nerve Fiber Layer and Minimum Rim Width Changes in Glaucoma

Higgins,

Yang,

Gardiner

2024

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

Purpose This study aims to determine whether OCT-derived rates of change in minimum rim width (MRW) are associated with and can potentially predict corresponding alterations in retinal nerve fiber layer thickness (RNFLT) in people with glaucoma. Methods The rates of change between six-monthly visits were taken from 568 eyes of 278 participants in the P3 Study. Structural equation models (SEM) assessed whether one parameter was predicted by the concurrent or previous rate of the other parameter, after adjusting for its own rate in the previous time interval. Root mean square error of approximation (RMSEA, with 90% confidence intervals [CI]), Tucker Lewis index (TLI) and the comparative fit index (CFI) assessed goodness of fit. Results Models without a time lag provided a better fit for the data (RMSEA = 0.101 [CI, 0.089, 0.113]), compared to a model featuring a time lag in RNFLT (RMSEA = 0.114 [CI, 0.102, 0.126]) or MRW (RMSEA = 0.114 [CI, 0.102, 0.127]). The SEMs indicated that rates for both MRW and RNFLT were predicted by their own rate in the previous time interval and by the other measure's change in the concurrent time interval ( P > 0.001 for all). No evidence of a clinically significant time lag for either parameter was determined. Conclusions MRW and RNFLT exhibit concurrent changes over time in patients with glaucoma, with no clinically significant time lag determined. Translational Relevance RNFLT may be more useful than MRW in early glaucoma assessment because of its previously reported lower variability and reduced sensitivity to intraocular pressure changes.

show abstract

Comparing Rates of Change in Moderate to Advanced Glaucoma: Retinal Nerve Fiber Layer Versus Bruch Membrane Opening-Minimum Rim Width

Cited by 6 publications

References 30 publications

Current Status and Future Perspectives of Optic Nerve Imaging in Glaucoma

Current Status and Future Perspectives of Optic Nerve Imaging in Glaucoma

Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis

The Temporal Relation Between Rates of Retinal Nerve Fiber Layer and Minimum Rim Width Changes in Glaucoma

Contact Info

Product

Resources

About