Comparing reliabilities of strip and conventional patch testing

Geier, Johannes; Kreft, Burkhard; Pfützner, Wolfgang; Kuß, Oliver

doi:10.1111/cod.12758

Cited by 19 publications

(10 citation statements)

References 40 publications

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“…Patch testing on skin with part of the epidermis removed by prior standardised tape stripping (“strip patch testing”) has been advocated by some to increase the sensitivity of the patch test. This method has now been shown to be as reliable (reproducible upon synchronous application) as conventional patch testing [ 238 ]. However, it has been pointed out that a similar increase in sensitivity can also be achieved by increasing the patch test contact allergen dose and using the standard patch test procedure, if a false-negative result with the standard dose is suspected.…”

Section: Resultsmentioning

confidence: 99%

Contact Allergy: A Review of Current Problems from a Clinical Perspective

Uter

Werfel

White

et al. 2018

IJERPH

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Contact allergy is common, affecting 27% of the general population in Europe. Original publications, including case reports, published since 2016 (inclusive) were identified with the aim of collating a full review of current problems in the field. To this end, a literature search employing methods of systematic reviewing was performed in the Medline® and Web of Science™ databases on 28 January 2018, using the search terms (“contact sensitization” or “contact allergy”). Of 446 non-duplicate publications identified by above search, 147 were excluded based on scrutiny of title, abstract and key words. Of the remaining 299 examined in full text, 291 were deemed appropriate for inclusion, and main findings were summarised in topic sections. In conclusion, diverse sources of exposures to chemicals of widely-differing types and structures, continue to induce sensitisation in man and may result in allergic contact dermatitis. Many of the chemicals are “evergreen” but others are “newcomers”. Vigilance and proper investigation (patch testing) are required to detect and inform of the presence of these haptens to which our populations remain exposed.

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Section: Resultsmentioning

confidence: 99%

Contact Allergy: A Review of Current Problems from a Clinical Perspective

Uter

Werfel

White

et al. 2018

IJERPH

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“…30 The validity and reliability of this technique have been verified in prospective, randomized, investigator-blinded multicentre studies. 2,31 On the other hand, strip-patch testing has been found to be responsible for eliciting an inflammatory response by activating keratinocytes that may cause irritant reactions. 9 Additional strip-patch testing of healthy controls can help distinguish false-positive irritant reactions.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, false-negative patch test reactions may occur with TOMs if readings are not performed beyond 72-96 h or if the patch test reactivity is not enhanced by using appropriate methods, such as strip-patch testing. 1,2 Only a few studies from Europe and a case series from Brazil have investigated the characteristics of ACD from TOMs. [3][4][5][6][7] Age older than 40 years, female predominance and topical aminoglycoside antibiotics/antiglaucoma agents as the main culprits were commonly reported features.…”

Section: Introductionmentioning

confidence: 99%

Tobramycin and antiglaucoma agents as increasing culprits of periorbital allergic contact dermatitis from topical ophthalmic medications: A 24‐year study from Turkey

2023

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Background: Allergic contact dermatitis (ACD) from topical ophthalmic medications (TOMs) poses an additional disease burden to patients who already suffer from eye problems.Objectives: To investigate the epidemiological/clinical profile of patients with periorbital ACD from TOMs in Turkey.Patients and Methods: This was a retrospective, cross-sectional, single tertiary centre study based on files of 75 patch tested patients with suspected periorbital ACD from TOMs among a total of 2801 consecutively patch tested patients with suspected ACD of any origin between 1996 and 2019.Results: Periorbital ACD was diagnosed in 25 of 75 (33.3%) patients (female: male = 1.8:1; age range: 6-85 years) with suspected ACD from TOMs showing an overall prevalence of 0.9% (25/2801) among the whole patch test population.Atopy was not present. Tobramycin-containing TOMs were the most frequent culprits, followed by antiglaucoma preparations. Their frequency increased, whereas no new cases of neomycin-induced ACD were observed after 2011. Positivities with thimerosal were of unknown clinical relevance, while benzalkonium chloride (BAC) caused ACD in two patients. The diagnosis would be missed in each 20% of patients without performing day (D) 4 and D7 readings and strip-patch testing. Ten culprits were identified only by testing with patients' own TOMs in eight (32%) patients.Conclusions: Aminoglycosides, particularly tobramycin, were the leading cause of ACD from TOMs. The frequency of ACD from tobramycin and antiglaucoma medications increased after 2011. BAC was a rare but important allergen. Additional D4 and D7 readings, strip-patch testing, and testing with patients' own TOMs seem essential when patch testing with eye medications.

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“…In strip patch testing, the horny layer is reduced prior to allergen application to increase the sensitivity of the test [62].…”

Section: Additional In Vivo Test Methodsmentioning

confidence: 99%

“…If no plausible results with respect to the suspected contact dermatitis are obtained with conventional patch testing and special, clinically suspicious facts are present, modified procedures of patch testing and supplementary test methods may be considered (Table 4) [52,55,[60][61][62][63][64][65][66].…”

Section: Guiding Principlesmentioning

confidence: 99%

German S1 guideline: Contact dermatitis

Bauer

Mahler

Neustädter

et al. 2022

J Deutsche Derma Gesell

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Summary Contact dermatitis is an inflammation of the epidermis and dermis at the site of exposure triggered by external agents. The two main forms are irritant and allergic contact dermatitis, which cause significant health and socioeconomic costs in addition to a marked reduction in quality of life. The anamnesis and the clinical picture are decisive for the necessary diagnostic measures. The most accurate possible diagnostic classification of contact dermatitis by means of allergological testing is important for disease management, since not only classical eczema therapy but also avoidance of the exogenous triggering factors are of great importance here. The choice of therapy should be based on the acuity, clinical severity, morphology of the lesions and localization of the contact dermatitis. A combination of basic therapy, topical, physical, and systemic therapy adapted to the patient’s needs is required, whereby not all forms of therapy must be carried out simultaneously but can be used in a varying manner. Primary, secondary, and tertiary prevention strategies aim at the recognition of the triggering noxae or allergens with subsequent contact avoidance or minimization. The present S1‐guideline on contact dermatitis is primarily intended to provide dermatologists, allergologists and physicians working in allergology and occupational dermatology with a decision‐making aid for the selection and implementation of suitable and sufficient diagnostics, therapy, and prevention.

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Comparing reliabilities of strip and conventional patch testing

Cited by 19 publications

References 40 publications

Contact Allergy: A Review of Current Problems from a Clinical Perspective

Contact Allergy: A Review of Current Problems from a Clinical Perspective

Tobramycin and antiglaucoma agents as increasing culprits of periorbital allergic contact dermatitis from topical ophthalmic medications: A 24‐year study from Turkey

German S1 guideline: Contact dermatitis

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