Comparing the activity of propolis‐loaded nanoparticles or hydroethanolic extract on cytokine production by peripheral blood mononuclear cells

Sartori, Arthur Alves; Cardoso, Eliza de Oliveira; Santiago, Karina Basso; Conte, Fernanda Lopes; Tasca, Karen Ingrid; Justino, Isabela A; Marincek, Andréia; Marcato, Priscyla D.; Bastos, Jairo Kenupp; Sforcin, José Maurício

doi:10.1002/ptr.7910

Phytotherapy Research

2023

DOI: 10.1002/ptr.7910

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Comparing the activity of propolis‐loaded nanoparticles or hydroethanolic extract on cytokine production by peripheral blood mononuclear cells

Arthur Alves Sartori

Eliza de Oliveira Cardoso

Karina Basso Santiago

et al.

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2024

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Antimicrobial, Antioxidant, and Anticancer Effects of Nanoencapsulated Brazilian Red Propolis Extract: Applications in Cancer Therapy

Justino,

Furlan,

Ferreira

et al. 2024

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This study evaluates the antimicrobial, antioxidant, and anticancer effects of Brazilian red propolis extract (BRPE) and its nanoencapsulated form (NCBRPE) to address bacteria and conditions associated with the ovarian cancer microenvironment. The NCBRPE showed an average size of 178.3 ± 3.3 nm, a polydispersity index (PdI) of 0.06, and an encapsulation efficiency exceeding 97% for the main bioactive compounds of propolis. Antimicrobial assays revealed that BRPE exhibited minimum inhibitory concentrations (MICs) ranging from 4 to 256 mg/L against seven bacterial strains, while NCBRPE demonstrated sustained efficacy, with a biofilm inhibitory concentration (BIC) of 128 mg/L against Burkholderia cepacia. In clonogenic assays, NCBRPE reduced long-term cancer cell proliferation, achieving a 10-fold decrease in colony formation compared to untreated controls, significantly outperforming BRPE. Flow cytometry indicated that NCBRPE induced apoptosis in 29% ± 0.4 of ovarian cancer cells (OVCAR-3). Additionally, the DPPH assay confirmed the antioxidant activity of NCBRPE, demonstrating that it retained most of the extract’s original antioxidant capacity. This was further supported by oxidative burst assays, which showed a significant reduction in reactive oxygen species (ROS) production in neutrophils. These findings position NCBRPE as a multi-functional therapeutic candidate for managing infections, oxidative stress, and tumor progression in the ovarian cancer microenvironment.

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Antimicrobial, Antioxidant, and Anticancer Effects of Nanoencapsulated Brazilian Red Propolis Extract: Applications in Cancer Therapy

Justino,

Furlan,

Ferreira

et al. 2024

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Comparing the activity of propolis‐loaded nanoparticles or hydroethanolic extract on cytokine production by peripheral blood mononuclear cells

Cited by 1 publication

References 10 publications

Antimicrobial, Antioxidant, and Anticancer Effects of Nanoencapsulated Brazilian Red Propolis Extract: Applications in Cancer Therapy

Antimicrobial, Antioxidant, and Anticancer Effects of Nanoencapsulated Brazilian Red Propolis Extract: Applications in Cancer Therapy

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