Comparing the application of various engineered xenografts for skin defects: A systematic review

Salloum, Antoine; Bazzi, Nagham; Squires, Stephen L.; Chu, Thomas; Benedetto, Paul X.; Benedetto, Anthony V.

doi:10.1111/jocd.15517

Cited by 9 publications

(4 citation statements)

References 65 publications

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“…In the early 1990s, the term “tissue engineered skin” was coined to describe the creation of a product comprised of human skin and bio-scaffolds that have the capacity to replace damaged human skin while resembling its natural function and structural characteristics, such as maintaining flexibility, acting as a protective barrier, and preventing transepidermal water loss ( 95 ). Examples of composite tissue engineered skin include BLCC and DRT.…”

Section: Class IIImentioning

confidence: 99%

“…However, xenografts confer the advantages of being lower cost, in unlimited supply, and having lower risk of disease transmission than their allograft counterparts (92). Xenografts used in the treatment of chronic wounds include porcine, bovine, and more recently, fish (94,95). A major advantage of the use of fish skin grafts over other types of xenografts include lower risk of viral transmission, enabling mild processing that preserves skin integrity which contains beneficial collagen, elastin, and Omega-3 polyunsaturated fatty acids thought to improve reepithelialization and microbial defense (93,96,97).…”

Section: Xenograftsmentioning

confidence: 99%

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Skin substitutes as treatment for chronic wounds: current and future directions

Vecin,

Kirsner

2023

Front. Med.

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Chronic wounds such as diabetic foot ulcers and venous leg ulcers place a significant burden on the healthcare system and in some cases, have 5-year mortality rates comparable to cancer. They negatively impact patients’ quality of life due to pain, odor, decreased mobility, and social isolation. Skin substitutes are an advanced therapy recommended for wounds that fail to show decrease in size with standard care. The choice of substitute used should be based on evidence, which often differs based on wound etiology. There are more than 75 skin substitutes currently available, and that number is rising. In this review, we discuss current management and future directions of chronic wounds while providing a review of available randomized control trial data for various skin substitutes.

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Section: Class IIImentioning

confidence: 99%

Section: Xenograftsmentioning

confidence: 99%

Skin substitutes as treatment for chronic wounds: current and future directions

Vecin,

Kirsner

2023

Front. Med.

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“…It also has great ability to accelerate re-epithelialization and promote angiogenesis and Allografts and xenografts with amniotic membrane are temporary biological replacements for the epidermis. Xenografts have been used in the treatment of burns since the 1960s [38]. Some clinical studies indicate that these dressings also have a positive effect on the healing process, as they diminish the risk of infection and reduce the frequency of dressing changes [39].…”

Section: Burn Wound Managementmentioning

confidence: 99%

Alloplastic Epidermal Skin Substitute in the Treatment of Burns

Barbachowska,

Korzeniowski,

Surowiecka

et al. 2023

Life

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The goal of burn wound treatment is to ensure rapid epithelialization in superficial burns and the process of rebuilding the lost skin in deep burns. Topical treatment plays an important role. One of the innovations in the field of synthetic materials dedicated to the treatment of burns is epidermal skin substitutes. Since the introduction of Suprathel®, the alloplastic epidermal substitute, many research results have been published in which the authors investigated the properties and use of this substitute in the treatment of wounds of various origins, including burn wounds. Burn wounds cause both physical and psychological discomfort, which is why ensuring comfort during treatment is extremely important. Alloplastic epidermal substitute, due to its biodegradability, plasticity, no need to remove the dressing until healing, and the associated reduction in pain, is an alternative for treating burns, especially in children.

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“…Tissues/Organs Products Skin Grafix, [ 135] Epicel, [ 136] PermaDerm, Bioseed-S, MySkin, [ 137] Recell/cell spray, Laserskin, Activskin, [ 138] Apligraf, OrCel, AlloDerm, [ 139] MatriDerm, [ 140,141] Integra, Biobrane, Hyalograft 3D, Dermagraft, TransCyte, Lando, etc.…”

Section: Introductionmentioning

confidence: 99%

Advances in Microgravity Directed Tissue Engineering

Cui¹,

Liu

Zhao

et al. 2023

Adv Healthcare Materials

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Tissue engineering aims to generate functional biological substitutes to repair, sustain, improve, or replace tissue function affected by disease. With the rapid development of space science, the application of simulated microgravity has become an active topic in the field of tissue engineering. There is a growing body of evidence demonstrating that microgravity offers excellent advantages for tissue engineering by modulating cellular morphology, metabolism, secretion, proliferation, and stem cell differentiation. To date, there have been many achievements in constructing bioartificial spheroids, organoids, or tissue analogs with or without scaffolds in vitro under simulated microgravity conditions. Here, the current status, recent advances, challenges, and prospects of microgravity related to tissue engineering are reviewed. Current simulated‐microgravity devices and cutting‐edge advances of microgravity for biomaterials‐dependent or biomaterials‐independent tissue engineering to offer a reference for guiding further exploration of simulated microgravity strategies to produce engineered tissues are summarized and discussed.

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Comparing the application of various engineered xenografts for skin defects: A systematic review

Cited by 9 publications

References 65 publications

Skin substitutes as treatment for chronic wounds: current and future directions

Skin substitutes as treatment for chronic wounds: current and future directions

Alloplastic Epidermal Skin Substitute in the Treatment of Burns

Advances in Microgravity Directed Tissue Engineering

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